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NOXA Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6269901

MBS6269901 is an antibody targeting NOXA. Also known as NOXA, NT (Phorbol-12-myristate-13-acetate-induced Protein 1, PMA-induced Protein 1, Immediate-early-response Protein APR, Protein Noxa, PMAIP1) (PE). Reactive in Human. Host: Rabbit. More details

$950 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NOXA, Polyclonal Antibody
Full Product Name
NOXA, NT (Phorbol-12-myristate-13-acetate-induced Protein 1, PMA-induced Protein 1, Immediate-early-response Protein APR, Protein Noxa, PMAIP1) (PE)
Product Gene Name
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Immunoaffinity chromatography.
Specificity
Recognizes human NOXA. Species sequence homology: Orangutan (100%).
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
7
OMIM
D90070 mRNA
3D Structure
ModBase 3D Structure for Q13794
Immunogen
Synthetic linear peptide corresponding to human NOXA at N-terminal (KLH).
Conjugate
PE
Positive Control
Osteoblasts in human bone tissue
Note
Preservative Free

Product Categories/Family for anti-NOXA antibody

Applications Tested/Suitable for anti-NOXA antibody
Immunohistochemistry (IHC)
Application Notes for anti-NOXA antibody
IHC: 1:500
Applications are based on unconjugated antibody.

Product References and Citations for anti-NOXA antibody

1. Elgendy, M., et al. (2011). Mol Cell. 42(1):23-35. 2. Lowman, X.H., et al. (2010). Mol Cell. 10(40): 823-833. 3. Samudio, I., et al. (2010). J Clin Invest. 120(1):142-156. 4. Oda, E., et al. (2000). Science. 288(5468): 1053-1058. 5. Baou, M., et al. (2010). Haematologica. 95(9): 1510-1518.

Other Notes

Small volumes of anti-NOXA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NOXA. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
phorbol-12-myristate-13-acetate-induced protein 1
NCBI Official Synonym Full Names
phorbol-12-myristate-13-acetate-induced protein 1
NCBI Official Symbol
PMAIP1
NCBI Official Synonym Symbols
APR; NOXA
UniProt Protein Name
Phorbol-12-myristate-13-acetate-induced protein 1
UniProt Synonym Protein Names
Immediate-early-response protein APR; Protein Noxa
UniProt Gene Name
PMAIP1
UniProt Synonym Gene Names
NOXA; PMA-induced protein 1
NCBI Protein Information
phorbol-12-myristate-13-acetate-induced protein 1

UniProt Comments for NOXA

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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