Rabbit Anti-NPFF Polyclonal Antibody – Cat# MBS8546519

NPFF Antibody – Rabbit Polyclonal

Name: NPFF Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS8546519
Price: 380 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8546519

Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and… More details

$380 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NPFF, Polyclonal Antibody

Full Product Name

NPFF Rabbit pAb

Product Gene Name

anti-NPFF antibody

Product Synonym Names

FMRFAL

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.

Purity/Purification

Affinity Purified

Preparation and Storage

Store at -20 degree C. Avoid freeze/thaw cycles.

Molecular Weight

12kDa

OMIM

604643

3D Structure

ModBase 3D Structure for O15130

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 34-113 of human NPFF (NP_003708.1).

Cellular Localization

Secreted

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-NPFF antibody

Western Blot (WB)

Application Notes for anti-NPFF antibody

WB: 1:500-1:2000

Other Notes

Small volumes of anti-NPFF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NPFF purchase

MBS8546519 is an antibody targeting NPFF. Also known as NPFF Rabbit pAb. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NPFF. It may not necessarily be applicable to this product.

NCBI GI #

8134595

NCBI GeneID

8620

NCBI Accession #

O15130.1

UniProt Primary Accession #

O15130

UniProt Related Accession #

O15130

NCBI Official Full Name

Pro-FMRFamide-related neuropeptide FF

NCBI Official Synonym Full Names

neuropeptide FF-amide peptide precursor

NCBI Official Symbol

NPFF

NCBI Official Synonym Symbols

FMRFAL

UniProt Protein Name

Pro-FMRFamide-related neuropeptide FF

UniProt Synonym Protein Names

FMRFamide-related peptidesCleaved into the following 3 chains:Neuropeptide SF; NPSF; Neuropeptide FF; NPFF; Neuropeptide AF; NPAF

Protein Family

Pro-FMRFamide-related neuropeptide

UniProt Gene Name

NPFF

UniProt Synonym Gene Names

NPSF; NPFF; NPAF

UniProt Entry Name

NPFF_HUMAN

NCBI Protein Information

pro-FMRFamide-related neuropeptide FF

NCBI Summary for NPFF

This gene encodes a member of the FMRFamide related peptide (FARP) family of neuropeptides. The encoded preproprotein is proteolytically processed to generate multiple amidated peptides. These peptides may play a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. Patients with hypertension exhibit decreased expression of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

UniProt Comments for NPFF

NPFF: Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels. Belongs to the FARP (FMRFamide related peptide) family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: extracellular space; dendrite; extracellular region; perikaryon; nerve terminal; vesicle

Molecular Function: neuropeptide hormone activity; G-protein-coupled receptor binding; receptor binding

Biological Process: response to drug; negative regulation of heart rate; maternal process involved in pregnancy; response to morphine; negative regulation of appetite; negative regulation of insulin secretion; vasopressin secretion; synaptic transmission; elevation of cytosolic calcium ion concentration; neuropeptide signaling pathway; spinal cord development; regulation of sensory perception of pain; regulation of excitatory postsynaptic membrane potential; positive regulation of blood pressure; acute inflammatory response to antigenic stimulus

Research Articles on NPFF

1. Our results...highlight the neuropeptide FF-amide peptide encoding gene (NPFF) as a novel candidate risk gene for both migraine with aura and migraine without aura

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NPFF antibody

Reference Product	PubMed Publications
QRFP antibody	>7 publications with NPFF and QRFP
CCK antibody	>6 publications with NPFF and CCK
NPFFR2 antibody	>4 publications with NPFF and NPFFR2
QRFPR antibody	>2 publications with NPFF and QRFPR
NPFFR1 antibody	>2 publications with NPFF and NPFFR1

Pathways associated with anti-NPFF antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies	Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Orexin And Neuropeptides FF And QRFP Bind To Their Respective Receptors Pathway antibodies	Orexin And Neuropeptides FF And QRFP Bind To Their Respective Receptors Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with anti-NPFF antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>15 publications with NPFF and Inflammation
Hemorrhage Antibodies	>3 publications with NPFF and Hemorrhage
Kidney Diseases Antibodies	>1 publications with NPFF and Kidney Diseases
Edema Antibodies	>1 publications with NPFF and Edema
Drug Hypersensitivity Antibodies	>1 publications with NPFF and Drug Hypersensitivity

Organs/Tissues associated with anti-NPFF antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>159 publications with NPFF and Brain
Heart Antibodies	>15 publications with NPFF and Heart
Intestine Antibodies	>6 publications with NPFF and Intestine
Kidney Antibodies	>5 publications with NPFF and Kidney
Pancreas Antibodies	>3 publications with NPFF and Pancreas
Eye Antibodies	>2 publications with NPFF and Eye
Epididymis Antibodies	>1 publications with NPFF and Epididymis
Uncharacterized Tissue Antibodies	>1 publications with NPFF and Uncharacterized Tissue