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NR5A1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6326682

NR5A1 is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this protein are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian… More details

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Product Overview

Online Datasheet in PDF
Product Name
NR5A1, Polyclonal Antibody
Full Product Name
NR5A1, NT (NR5A1, AD4BP, FTZF1, SF1, Steroidogenic factor 1, Adrenal 4-binding protein, Fushi tarazu factor homolog 1, Nuclear receptor subfamily 5 group A member 1, Steroid hormone receptor Ad4BP) (MaxLight 405)
Product Gene Name
anti-NR5A1 antibody
Product Synonym Names
NR5A1; AD4BP; FTZF1; SF1; Steroidogenic factor 1; Adrenal 4-binding protein; Fushi tarazu factor homolog 1; Nuclear receptor subfamily 5 group A member 1; Steroid hormone receptor Ad4BP
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
51,636 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (127243515..127269699, complement). Location: 9q33
OMIM
184757
3D Structure
ModBase 3D Structure for Q13285
Immunogen
NR5A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-100 amino acids from the N-terminal region of human NR5A1.
Conjugate
MaxLight405
Note
Preservative Free

Product Categories/Family for anti-NR5A1 antibody

Antibodies; Binding Proteins
Applications Tested/Suitable for anti-NR5A1 antibody
Flow Cytometry (FC/FACS), FLISA, Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-NR5A1 antibody
FC/FACS: 1:10-50
FLISA: 1:1,000
IHC: 1:50-100
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-NR5A1 antibody

Almeida, M.Q., et al. J. Clin. Endocrinol. Metab. 95(3):1458-1462(2010). Ramayya, M.S., et al. J. Steroid Biochem. Mol. Biol. 119 (1-2), 14-25 (2010). Catalano, S., et al. J. Biol. Chem. 285(8):5581-5593(2010).

Other Notes

Small volumes of anti-NR5A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NR5A1 purchase

MBS6326682 is an antibody targeting NR5A1. Also known as NR5A1, NT (NR5A1, AD4BP, FTZF1, SF1, Steroidogenic factor 1, Adrenal 4-binding protein, Fushi tarazu factor homolog 1, Nuclear receptor subfamily 5 group A member 1, Steroid hormone receptor Ad4BP) (MaxLight 405). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NR5A1. It may not necessarily be applicable to this product.

NCBI GI #
20070193
NCBI GeneID
2516
NCBI Accession #
NP_004950.2
UniProt Primary Accession #
Q13285
UniProt Secondary Accession #
O15196; Q5T6F5
UniProt Related Accession #
Q13285
GenBank Nucleotide #
NM_004959.4
NCBI Official Full Name
steroidogenic factor 1
NCBI Official Synonym Full Names
nuclear receptor subfamily 5, group A, member 1
NCBI Official Symbol
NR5A1
NCBI Official Synonym Symbols
ELP; SF1; FTZ1; POF7; SF-1; AD4BP; FTZF1; SPGF8; SRXY3
UniProt Protein Name
Steroidogenic factor 1
UniProt Synonym Protein Names
Adrenal 4-binding protein; Fushi tarazu factor homolog 1; Nuclear receptor subfamily 5 group A member 1; Steroid hormone receptor Ad4BP
Protein Family
Steroidogenic factor
UniProt Gene Name
NR5A1
UniProt Synonym Gene Names
AD4BP; FTZF1; SF1; SF-1; STF-1
UniProt Entry Name
STF1_HUMAN
NCBI Protein Information
steroidogenic factor 1; STF-1; nuclear receptor AdBP4; steroidogenic factor-1; adrenal 4 binding protein; adrenal 4-binding protein; fushi tarazu factor homolog 1; steroid hormone receptor Ad4BP; steroidogenic factor 1 nuclear receptor

NCBI Summary for NR5A1

The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008]
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UniProt Comments for NR5A1

STF-1: a nuclear hormone receptor of the NR5 subfamily. Essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes.

Protein type: Nuclear receptor

Chromosomal Location of Human Ortholog: 9q33

Cellular Component: nucleoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; ligand-dependent nuclear receptor activity; enzyme binding; DNA binding; zinc ion binding; sequence-specific DNA binding; transcription coactivator activity; double-stranded DNA binding; steroid hormone receptor activity; phospholipid binding; chromatin binding

Biological Process: transcription initiation from RNA polymerase II promoter; tissue development; intracellular receptor-mediated signaling pathway; adrenal gland development; primary sex determination; male gonad development; multicellular organismal aging; regulation of steroid biosynthetic process; cell-cell signaling; luteinization; hormone metabolic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; maintenance of protein localization in nucleus; cell differentiation

Disease: Premature Ovarian Failure 7; 46,xy Sex Reversal 3; Spermatogenic Failure 8
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Research Articles on NR5A1

1. SF-1 regulates LRH-1 expression in ovarian granulosa cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NR5A1 antibody

 Reference Product  PubMed Publications
 NR0B1 antibody  >73 publications with NR5A1 and NR0B1
 JUN antibody  >59 publications with NR5A1 and JUN
 SOX9 antibody  >24 publications with NR5A1 and SOX9
 GATA4 antibody  >20 publications with NR5A1 and GATA4
 SP1 antibody  >18 publications with NR5A1 and SP1
 CTNNB1 antibody  >10 publications with NR5A1 and CTNNB1
 NCOA1 antibody  >5 publications with NR5A1 and NCOA1
 TRERF1 antibody  >5 publications with NR5A1 and TRERF1
 SOX2 antibody  >5 publications with NR5A1 and SOX2
 PITX1 antibody  >3 publications with NR5A1 and PITX1

Pathways associated with anti-NR5A1 antibody

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Ovarian Infertility Genes Pathway antibodies  Ovarian Infertility Genes Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram

Diseases associated with anti-NR5A1 antibody

 Disease Name  Pubmed Publications
 Disorders of Sex Development Antibodies  >66 publications with NR5A1 and Disorders of Sex Development
 Urogenital Abnormalities Antibodies  >61 publications with NR5A1 and Urogenital Abnormalities
 Neoplasms Antibodies  >59 publications with NR5A1 and Neoplasms
 Adrenal Insufficiency Antibodies  >43 publications with NR5A1 and Adrenal Insufficiency
 Carcinoma Antibodies  >33 publications with NR5A1 and Carcinoma
 46,XY Sex Reversal 3 Antibodies  >32 publications with NR5A1 and 46,XY Sex Reversal 3
 Gonadal Dysgenesis, 46,XY Antibodies  >30 publications with NR5A1 and Gonadal Dysgenesis, 46,XY
 Ovarian Diseases Antibodies  >26 publications with NR5A1 and Ovarian Diseases
 Primary Ovarian Insufficiency Antibodies  >20 publications with NR5A1 and Primary Ovarian Insufficiency
 Genital Diseases, Male Antibodies  >20 publications with NR5A1 and Genital Diseases, Male

Organs/Tissues associated with anti-NR5A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Adrenal Gland Antibodies  >130 publications with NR5A1 and Adrenal Gland
 Testis Antibodies  >112 publications with NR5A1 and Testis
 Ovary Antibodies  >111 publications with NR5A1 and Ovary
 Brain Antibodies  >59 publications with NR5A1 and Brain
 Liver Antibodies  >49 publications with NR5A1 and Liver
 Spleen Antibodies  >13 publications with NR5A1 and Spleen
 Thymus Antibodies  >4 publications with NR5A1 and Thymus
 Connective Tissue Antibodies  >2 publications with NR5A1 and Connective Tissue
 Uncharacterized Tissue Antibodies  >1 publications with NR5A1 and Uncharacterized Tissue
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