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NRG4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7003567

Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. More details

$230 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NRG4, Polyclonal Antibody
Full Product Name
NRG4 Antibody; Biotin conjugated
Product Gene Name
anti-NRG4 antibody
Product Synonym Names
Pro-neuregulin-4; membrane-bound isoform; Pro-NRG4Cleaved into the following chain:Neuregulin-4; NRG-4; NRG4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
>95%,Protein G purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
Matching Pairs
Unconjugated Antibody: NRG4 (MBS7006703)
Biotin Conjugated Antibody: NRG4 (MBS7003567)
Molecular Weight
12,722 Da
OMIM
610894
3D Structure
ModBase 3D Structure for Q8WWG1
Immunogen
Recombinant human Pro-neuregulin-4, membrane-bound isoform protein
Conjugation
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-NRG4 antibody
ELISA (EIA)

Other Notes

Small volumes of anti-NRG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NRG4 purchase

MBS7003567 is an antibody targeting NRG4. Also known as NRG4 Antibody; Biotin conjugated. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NRG4. It may not necessarily be applicable to this product.

NCBI GI #
20070380
NCBI GeneID
145957
NCBI Accession #
NP_612640.1
UniProt Primary Accession #
Q8WWG1
UniProt Secondary Accession #
A6NIE8
UniProt Related Accession #
Q8WWG1
GenBank Nucleotide #
NM_138573.3
NCBI Official Full Name
pro-neuregulin-4, membrane-bound isoform
NCBI Official Synonym Full Names
neuregulin 4
NCBI Official Symbol
NRG4
NCBI Official Synonym Symbols
HRG4
UniProt Protein Name
Pro-neuregulin-4, membrane-bound isoform
Protein Family
Pro-neuregulin
UniProt Gene Name
NRG4
UniProt Synonym Gene Names
Pro-NRG4; NRG-4
UniProt Entry Name
NRG4_HUMAN
NCBI Protein Information
pro-neuregulin-4, membrane-bound isoform

NCBI Summary for NRG4

The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]

UniProt Comments for NRG4

NRG4: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. Belongs to the neuregulin family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q24.2

Cellular Component: extracellular region; extracellular space; integral to membrane; intracellular; plasma membrane

Molecular Function: growth factor activity; protein binding; receptor binding

Biological Process: activation of MAPKK activity; axon guidance; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; organ development; phosphoinositide-mediated signaling; Ras protein signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway
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Research Articles on NRG4

1. Nrg4 might have a protective role in the development of Non-alcoholic fatty liver disease (NAFLD).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NRG4 antibody

 Reference Product  PubMed Publications
 ERBB4 antibody  >10 publications with NRG4 and ERBB4
 NRG3 antibody  >9 publications with NRG4 and NRG3
 NRG1 antibody  >8 publications with NRG4 and NRG1
 NRG2 antibody  >8 publications with NRG4 and NRG2
 ERBB2 antibody  >4 publications with NRG4 and ERBB2
 EREG antibody  >3 publications with NRG4 and EREG
 EGFR antibody  >2 publications with NRG4 and EGFR
 HBEGF antibody  >1 publications with NRG4 and HBEGF

Pathways associated with anti-NRG4 antibody

 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Constitutive Signaling By Aberrant PI3K In Cancer Pathway antibodies  Constitutive Signaling By Aberrant PI3K In Cancer Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram

Diseases associated with anti-NRG4 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2 publications with NRG4 and Carcinoma
 Cardiovascular Diseases Antibodies  >2 publications with NRG4 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >2 publications with NRG4 and Disease Models, Animal
 Fatty Liver Antibodies  >2 publications with NRG4 and Fatty Liver
 Liver Diseases Antibodies  >2 publications with NRG4 and Liver Diseases
 Neoplasms, Experimental Antibodies  >1 publications with NRG4 and Neoplasms, Experimental
 Vascular Diseases Antibodies  >1 publications with NRG4 and Vascular Diseases
 Adenocarcinoma Antibodies  >1 publications with NRG4 and Adenocarcinoma
 Liver Neoplasms Antibodies  >1 publications with NRG4 and Liver Neoplasms
 Insulin Resistance Antibodies  >1 publications with NRG4 and Insulin Resistance

Organs/Tissues associated with anti-NRG4 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >5 publications with NRG4 and Liver
 Connective Tissue Antibodies  >3 publications with NRG4 and Connective Tissue
 Prostate Antibodies  >2 publications with NRG4 and Prostate
 Blood Antibodies  >2 publications with NRG4 and Blood
 Intestine Antibodies  >2 publications with NRG4 and Intestine
 Bladder Antibodies  >1 publications with NRG4 and Bladder
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