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NRG4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9402540

Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by theNRG4 gene. Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in… More details

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Product Overview

Online Datasheet in PDF
Product Name
NRG4, Polyclonal Antibody
Full Product Name
NRG4 Antibody
Product Gene Name
Product Synonym Names
HRG4
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Purity/Purification
Antigen affinity purification.
Concentration
2.4 mg/ml (lot specific)
Specificity
The antibody detects endogenous levels of total NRG4 protein.
Preparation and Storage
Store at -20 degree C
Molecular Weight
12,722 Da
OMIM
610894
3D Structure
ModBase 3D Structure for Q8WWG1
Immunogen Type
Recombinant Protein
Immunogen Description
Fusion protein corresponding to residues near the N terminal of human neuregulin 4
Target Name
NRG4

Product Categories/Family for anti-NRG4 antibody

Applications Tested/Suitable for anti-NRG4 antibody
Immunohistochemistry (IHC)
Application Notes for anti-NRG4 antibody
Immunohistochemistry: 1:50-1:200

Immunohistochemistry (IHC) of anti-NRG4 antibody

Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/60.
Rabbit Anti-NRG4 Polyclonal Antibody – Cat# MBS9402540

Immunohistochemistry (IHC) of anti-NRG4 antibody

Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using at dilution 1/60.
Rabbit Anti-NRG4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9402540

Other Notes

Small volumes of anti-NRG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NRG4 purchase

MBS9402540 is an antibody targeting NRG4. Also known as NRG4 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NRG4. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
pro-neuregulin-4, membrane-bound isoform
NCBI Official Synonym Full Names
neuregulin 4
NCBI Official Symbol
NRG4
NCBI Official Synonym Symbols
HRG4
UniProt Protein Name
Pro-neuregulin-4, membrane-bound isoform
Protein Family
UniProt Gene Name
NRG4
UniProt Synonym Gene Names
Pro-NRG4; NRG-4
UniProt Entry Name
NRG4_HUMAN
NCBI Protein Information
pro-neuregulin-4, membrane-bound isoform

NCBI Summary for NRG4

The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]

UniProt Comments for NRG4

NRG4: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. Belongs to the neuregulin family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q24.2

Cellular Component: extracellular space; extracellular region; integral to membrane; plasma membrane

Molecular Function: growth factor activity; receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; organ development; innate immune response
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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