Rabbit Anti-NRTN Polyclonal Antibody – Cat# MBS6326840

NRTN Antibody – Rabbit Polyclonal

Name: NRTN Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6326840
Price: 1025 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6326840

Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq]. More details

$1025 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NRTN, Polyclonal Antibody

Full Product Name

NRTN, ID (NRTN, Neurturin) (MaxLight 750)

Product Gene Name

anti-NRTN antibody

Product Synonym Names

NRTN; Neurturin

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

22,405 Da

OMIM

602018

3D Structure

ModBase 3D Structure for Q99748

Immunogen

NRTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-75 amino acids from the Central region of human NRTN.

Conjugate

MaxLight750

Note

Preservative Free

Product Categories/Family for anti-NRTN antibody

Antibodies; Proteins

Applications Tested/Suitable for anti-NRTN antibody

Western Blot (WB), FLISA

Application Notes for anti-NRTN antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-NRTN antibody

Fernandez, R.M., et al. J. Pediatr. Surg. 43(11):2042-2047(2008). Adly, M.A., et al. J. Am. Acad. Dermatol. 58(2):238-250(2008). Yoong, L.F., et al. J. Neurosci. 27(21):5603-5614(2007). Yoong, L.F., et al. J. Neurochem. 98(4):1149-1158(2006). Vargas-Leal, V., et al. J. Immunol. 175(4):2301-2308(2005).

Other Notes

Small volumes of anti-NRTN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NRTN purchase

MBS6326840 is an antibody targeting NRTN. Also known as NRTN, ID (NRTN, Neurturin) (MaxLight 750). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NRTN. It may not necessarily be applicable to this product.

NCBI GI #

4758826

NCBI GeneID

4902

NCBI Accession #

NP_004549.1

UniProt Primary Accession #

Q99748

UniProt Secondary Accession #

B2RPE8

UniProt Related Accession #

Q99748

GenBank Nucleotide #

NM_004558.3

NCBI Official Full Name

neurturin preproprotein

NCBI Official Synonym Full Names

neurturin

NCBI Official Symbol

NRTN

NCBI Official Synonym Symbols

NTN

UniProt Protein Name

Neurturin

Protein Family

Neurturin

UniProt Gene Name

NRTN

UniProt Entry Name

NRTN_HUMAN

NCBI Protein Information

neurturin; prepro-neurturin

NCBI Summary for NRTN

UniProt Comments for NRTN

NRTN: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Belongs to the TGF-beta family. GDNF subfamily.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: axon; extracellular region

Molecular Function: growth factor activity; receptor binding

Biological Process: nervous system development; axon guidance; MAPKKK cascade; nerve development; neural crest cell migration; neurite development; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Hirschsprung Disease, Susceptibility To, 1

Research Articles on NRTN

1. In the cochlea, NTN immunostaining was found in the supporting cells of organ of Corti, including Deiters' cells, Hensen cells as well as Claudius' cells. In the spiral ganglia, NTN was seen in both the cell bodies and the nerve fibers of neurons.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NRTN antibody

Reference Product	PubMed Publications
GDNF antibody	>145 publications with NRTN and GDNF
RET antibody	>109 publications with NRTN and RET
GFRA2 antibody	>43 publications with NRTN and GFRA2
GFRA1 antibody	>36 publications with NRTN and GFRA1
ARTN antibody	>22 publications with NRTN and ARTN
PSPN antibody	>11 publications with NRTN and PSPN
GFRA3 antibody	>7 publications with NRTN and GFRA3
NCAM1 antibody	>4 publications with NRTN and NCAM1

Pathways associated with anti-NRTN antibody

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
NCAM Signaling For Neurite Out-growth Pathway antibodies	NCAM Signaling For Neurite Out-growth Pathway Diagram
NCAM1 Interactions Pathway antibodies	NCAM1 Interactions Pathway Diagram

Diseases associated with anti-NRTN antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>29 publications with NRTN and Nervous System Diseases
Nerve Degeneration Antibodies	>23 publications with NRTN and Nerve Degeneration
Congenital Abnormalities Antibodies	>8 publications with NRTN and Congenital Abnormalities
Hirschsprung Disease Antibodies	>8 publications with NRTN and Hirschsprung Disease
Inflammation Antibodies	>5 publications with NRTN and Inflammation
Weight Loss Antibodies	>3 publications with NRTN and Weight Loss
Necrosis Antibodies	>2 publications with NRTN and Necrosis
Hypertrophy Antibodies	>2 publications with NRTN and Hypertrophy
Fetal Death Antibodies	>2 publications with NRTN and Fetal Death
Kidney Neoplasms Antibodies	>2 publications with NRTN and Kidney Neoplasms

Organs/Tissues associated with anti-NRTN antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>67 publications with NRTN and Brain
Eye Antibodies	>17 publications with NRTN and Eye
Muscle Antibodies	>14 publications with NRTN and Muscle
Intestine Antibodies	>14 publications with NRTN and Intestine
Pancreas Antibodies	>3 publications with NRTN and Pancreas
Lung Antibodies	>1 publications with NRTN and Lung