NUDT21 Antibody – Rabbit Polyclonal

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008]

CFIM25: Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export. Belongs to the Nudix hydrolase family. CPSF5 subfamily.

Protein type: Spliceosome; RNA-binding; RNA splicing

Chromosomal Location of Human Ortholog: 16q12.2

Cellular Component: centrosome; microtubule organizing center; mRNA cleavage factor complex; nucleoplasm; nucleus; paraspeckles

Molecular Function: AU-rich element binding; histone deacetylase binding; hydrolase activity; mRNA binding; protein binding; protein homodimerization activity; RNA binding

Biological Process: gene expression; mRNA 3'-end processing; mRNA polyadenylation; mRNA processing; nuclear mRNA splicing, via spliceosome; protein tetramerization; RNA splicing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter