Rabbit Anti-OS9 Polyclonal Antibody – Cat# MBS6329679

OS9 Antibody (C-term) western blot analysis in U937 cell line lysates (35ug/lane).This demonstrates the OS9 antibody detected the OS9 protein (arrow).

OS9 Antibody – Rabbit Polyclonal

Name: OS9 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6329679
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6329679

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

OS9, Polyclonal Antibody

Full Product Name

OS9, CT (OS9, Protein OS-9, Amplified in osteosarcoma 9) (PE)

Product Gene Name

anti-OS9 antibody

Product Synonym Names

OS9; Protein OS-9; Amplified in osteosarcoma 9

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

OMIM

609677

3D Structure

ModBase 3D Structure for Q13438

Immunogen

OS9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 520-549 amino acids from the C-terminal region of human OS9.

Conjugate

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-OS9 antibody

Antibodies; Transcription Factors

Applications Tested/Suitable for anti-OS9 antibody

Western Blot (WB), FLISA

Application Notes for anti-OS9 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-OS9 antibody

Feng, T., et al. Hum. Genet. 128(3):269-280(2010). Mikami, K., et al. Glycobiology 20(3):310-321(2010). Hosokawa, N., et al. J. Biol. Chem. 284(25):17061-17068(2009). Jansen, B.J., et al. Mol. Immunol. 46(4):505-515(2009). Alcock, F., et al. J. Mol. Biol. 385(4):1032-1042(2009).

Other Notes

Small volumes of anti-OS9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OS9 purchase

MBS6329679 is an antibody targeting OS9. Also known as OS9, CT (OS9, Protein OS-9, Amplified in osteosarcoma 9) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for OS9. It may not necessarily be applicable to this product.

NCBI GI #

63252870

NCBI GeneID

10956

NCBI Accession #

NP_001017958.1

NCBI Related Accession #

NP_006803.1

UniProt Primary Accession #

Q13438

UniProt Related Accession #

Q13438

GenBank Nucleotide #

NP_001017958.1

NCBI Official Full Name

protein OS-9 isoform 4

NCBI Official Synonym Full Names

OS9 endoplasmic reticulum lectin

NCBI Official Symbol

OS9

NCBI Official Synonym Symbols

OS-9; ERLEC2

UniProt Protein Name

Protein OS-9

UniProt Synonym Protein Names

Amplified in osteosarcoma 9

Protein Family

Protein

UniProt Gene Name

OS9

UniProt Entry Name

OS9_HUMAN

NCBI Protein Information

protein OS-9

UniProt Comments for OS9

OS9: Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. Belongs to the OS-9 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: endoplasmic reticulum lumen

Molecular Function: protein binding; protease binding; glycoprotein binding; carbohydrate binding

Biological Process: ER-associated protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination; protein retention in ER; protein targeting

Research Articles on OS9

1. The relative expression of OS9 and XTP3B and the distribution of glycan and non-glycan degrons within the same protein contribute to the fidelity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.