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OXSR1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6388169

The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq] More details

$1165 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
OXSR1, Polyclonal Antibody
Full Product Name
OXSR1 (Serine/Threonine-Protein Kinase OSR1, Oxidative Stress-Responsive 1 Protein, KIAA1101, OSR1) (MaxLight 550)
Product Gene Name
anti-OXSR1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human OXSR1.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
58,022 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (38207026..38296979). Location: 3p22.2
OMIM
604046
3D Structure
ModBase 3D Structure for O95747
Immunogen
Full length human OXSR1, aa1-527 (NP_005100.1).
Immunogen Sequence
MSEDSSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTLQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKESISNSELFPTTDPVGTLLQVPEQISAHLPQPAGQIATQPTQVSLPPTAEPAKTAQALSSGSGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS
Conjugate
MaxLight550
Note
Preservative Free

Product Categories/Family for anti-OXSR1 antibody

Antibodies; Protein Kinases
Applications Tested/Suitable for anti-OXSR1 antibody
Western Blot (WB)
Application Notes for anti-OXSR1 antibody
Applications are based on unconjugated antibody.

Other Notes

Small volumes of anti-OXSR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OXSR1 purchase

MBS6388169 is an antibody targeting OXSR1. Also known as OXSR1 (Serine/Threonine-Protein Kinase OSR1, Oxidative Stress-Responsive 1 Protein, KIAA1101, OSR1) (MaxLight 550). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for OXSR1. It may not necessarily be applicable to this product.

NCBI GI #
4826878
NCBI GeneID
9943
NCBI Accession #
NP_005100.1
UniProt Primary Accession #
O95747
UniProt Secondary Accession #
Q3LR53; Q7Z501; Q9UPQ1
UniProt Related Accession #
O95747
GenBank Nucleotide #
NM_005109.2
NCBI Official Full Name
serine/threonine-protein kinase OSR1
NCBI Official Synonym Full Names
oxidative stress responsive 1
NCBI Official Symbol
OXSR1
NCBI Official Synonym Symbols
OSR1
UniProt Protein Name
Serine/threonine-protein kinase OSR1
UniProt Synonym Protein Names
Oxidative stress-responsive 1 protein
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
OXSR1
UniProt Synonym Gene Names
KIAA1101; OSR1
UniProt Entry Name
OXSR1_HUMAN
NCBI Protein Information
serine/threonine-protein kinase OSR1; oxidative-stress responsive 1; oxidative stress-responsive 1 protein

UniProt Comments for OXSR1

OSR1: oxidative-stress responsive 1 protein is a ubiquitously expressed protein kinase of the STE20 family. Regulates Na-K-Cl cotransporter (NKCC) activity. Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton. Binds to and phosphorylates PAK1. Interacts and is phosphorylated by WNK1. Knockdown of either WNK1 or OXSR1 reduces NKCC activity. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. An important paralog of this gene is STRADB.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; EC 2.7.11.1; Kinase, protein; STE group; STE20 family; FRAY subfamily

Chromosomal Location of Human Ortholog: 3p22.2

Cellular Component: cytoplasm

Molecular Function: protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: peptidyl-threonine phosphorylation; response to oxidative stress; protein amino acid phosphorylation
Show more

Research Articles on OXSR1

1. SPAK and OSR1, which are often coexpressed in cells, can form functional heterodimers.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-OXSR1 antibody

 Reference Product  PubMed Publications
 PAK1 antibody  >1 publications with OXSR1 and PAK1

Diseases associated with anti-OXSR1 antibody

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >6 publications with OXSR1 and Hypertension
 Cardiovascular Diseases Antibodies  >2 publications with OXSR1 and Cardiovascular Diseases
 Necrosis Antibodies  >2 publications with OXSR1 and Necrosis
 Hyperkalemia Antibodies  >1 publications with OXSR1 and Hyperkalemia
 Kidney Diseases Antibodies  >1 publications with OXSR1 and Kidney Diseases
 Fibrosis Antibodies  >1 publications with OXSR1 and Fibrosis
 Myocardial Infarction Antibodies  >1 publications with OXSR1 and Myocardial Infarction
 Neoplasms Antibodies  >1 publications with OXSR1 and Neoplasms
 Lung Neoplasms Antibodies  >1 publications with OXSR1 and Lung Neoplasms

Organs/Tissues associated with anti-OXSR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with OXSR1 and Brain
 Blood Antibodies  >3 publications with OXSR1 and Blood
 Prostate Antibodies  >2 publications with OXSR1 and Prostate
 Nerve Antibodies  >2 publications with OXSR1 and Nerve
 Muscle Antibodies  >1 publications with OXSR1 and Muscle
 Kidney Antibodies  >1 publications with OXSR1 and Kidney
 Intestine Antibodies  >1 publications with OXSR1 and Intestine
 Pancreas Antibodies  >1 publications with OXSR1 and Pancreas
 Skin Antibodies  >1 publications with OXSR1 and Skin
 Lung Antibodies  >1 publications with OXSR1 and Lung
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