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p62Dok Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9401360

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin… More details

$260 / 0.05 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
p62Dok, Polyclonal Antibody
Full Product Name
p62Dok (Ab-362) Antibody
Product Gene Name
anti-p62Dok antibody
Product Synonym Names
DOK1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1.0 mg/ml (lot specific)
Specificity
The antibody detects endogenous level of total p62Dok protein.
Preparation and Storage
Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.
Molecular Weight
37,405 Da
OMIM
602919
3D Structure
ModBase 3D Structure for Q99704
Immunogen Type
Peptide-KLH
Immunogen Description
Peptide sequence around aa.360~364 (P-I-Y-D-E) derived from Human p62Dok.
Target Name
p62Dok

Product Categories/Family for anti-p62Dok antibody

Total protein Ab
Applications Tested/Suitable for anti-p62Dok antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-p62Dok antibody
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100

Western Blot (WB) of anti-p62Dok antibody

Western blot analysis of extracts from Jurkat cells using p62Dok(Ab-362) Antibody and the same antibody preincubated with blocking peptide.
Rabbit Anti-p62Dok Polyclonal Antibody – Cat# MBS9401360

Immunohistochemistry (IHC) of anti-p62Dok antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p62Dok(Ab-362) Antibody (left) or the same antibody preincubated with blocking peptide(right).
Rabbit Anti-p62Dok Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9401360

Other Notes

Small volumes of anti-p62Dok antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for p62Dok purchase

MBS9401360 is an antibody targeting p62Dok. Also known as p62Dok (Ab-362) Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for p62Dok. It may not necessarily be applicable to this product.

NCBI GI #
308737010
NCBI GeneID
1796
NCBI Accession #
NP_001184189.1
UniProt Primary Accession #
Q99704
UniProt Secondary Accession #
O43204; Q53TY2; Q9UHG6
UniProt Related Accession #
Q99704
GenBank Nucleotide #
NM_001197260.1
NCBI Official Full Name
docking protein 1 isoform 2
NCBI Official Synonym Full Names
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
NCBI Official Symbol
DOK1
NCBI Official Synonym Symbols
P62DOK
UniProt Protein Name
Docking protein 1
UniProt Synonym Protein Names
Downstream of tyrosine kinase 1; p62(dok); pp62
UniProt Gene Name
DOK1
UniProt Entry Name
DOK1_HUMAN
NCBI Protein Information
docking protein 1

NCBI Summary for p62Dok

The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
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UniProt Comments for p62Dok

DOK1: a docking protein that interacts with receptor tyrosine kinases. It is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2p13

Cellular Component: perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus

Molecular Function: protein binding; receptor signaling protein activity; insulin receptor binding

Biological Process: cell surface receptor linked signal transduction; Ras protein signal transduction; insulin receptor signaling pathway; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
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Research Articles on p62Dok

1. results support a model in which Dok1 phosphorylation normally suppresses localized Ras pathway activity in Crk-transformed cells via recruitment and/or activation of RasGAP

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-p62Dok antibody

 Reference Product  PubMed Publications
 SRC antibody  >62 publications with p62Dok and SRC
 LCK antibody  >6 publications with p62Dok and LCK
 FYN antibody  >5 publications with p62Dok and FYN
 TEC antibody  >5 publications with p62Dok and TEC
 SHC1 antibody  >4 publications with p62Dok and SHC1
 KIT antibody  >3 publications with p62Dok and KIT
 ABL1 antibody  >2 publications with p62Dok and ABL1
 GRB10 antibody  >1 publications with p62Dok and GRB10

Pathways associated with anti-p62Dok antibody

 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Fc-epsilon Receptor I Signaling In Mast Cells Pathway antibodies  Fc-epsilon Receptor I Signaling In Mast Cells Pathway Diagram
 Insulin Pathway antibodies  Insulin Pathway Diagram
 Kit Receptor Signaling Pathway antibodies  Kit Receptor Signaling Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 PDGFR-beta Signaling Pathway antibodies  PDGFR-beta Signaling Pathway Diagram
 Signaling Events Mediated By PTP1B Pathway antibodies  Signaling Events Mediated By PTP1B Pathway Diagram
 Signaling Events Mediated By Stem Cell Factor Receptor (c-Kit) Pathway antibodies  Signaling Events Mediated By Stem Cell Factor Receptor (c-Kit) Pathway Diagram

Diseases associated with anti-p62Dok antibody

 Disease Name  Pubmed Publications
 Leukemia Antibodies  >23 publications with p62Dok and Leukemia
 Neoplasms, Experimental Antibodies  >8 publications with p62Dok and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >5 publications with p62Dok and Disease Models, Animal
 Inflammation Antibodies  >4 publications with p62Dok and Inflammation
 Necrosis Antibodies  >4 publications with p62Dok and Necrosis
 Hypertrophy Antibodies  >3 publications with p62Dok and Hypertrophy
 Hyperplasia Antibodies  >2 publications with p62Dok and Hyperplasia
 Breast Neoplasms Antibodies  >2 publications with p62Dok and Breast Neoplasms
 Stomach Neoplasms Antibodies  >2 publications with p62Dok and Stomach Neoplasms
 Congenital Abnormalities Antibodies  >2 publications with p62Dok and Congenital Abnormalities

Organs/Tissues associated with anti-p62Dok antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >45 publications with p62Dok and Blood
 Bone Antibodies  >17 publications with p62Dok and Bone
 Bone Marrow Antibodies  >15 publications with p62Dok and Bone Marrow
 Lung Antibodies  >7 publications with p62Dok and Lung
 Muscle Antibodies  >6 publications with p62Dok and Muscle
 Heart Antibodies  >4 publications with p62Dok and Heart
 Embryonic Tissue Antibodies  >4 publications with p62Dok and Embryonic Tissue
 Adipose Tissue Antibodies  >3 publications with p62Dok and Adipose Tissue
 Connective Tissue Antibodies  >3 publications with p62Dok and Connective Tissue
 Spleen Antibodies  >3 publications with p62Dok and Spleen
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