Rabbit Anti-PAPSS2 Polyclonal Antibody – Cat# MBS6491977

PAPSS2 Antibody – Rabbit Polyclonal

Name: PAPSS2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6491977
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6491977

MBS6491977 is an antibody targeting PAPSS2. Also known as PAPSS2, NT (PAPS Synthase 2, PAPSS 2, 3'-phosphoadenosine 5'-phosphosulfate Synthase 2, ATPSK2, Bifunctional 3'-phosphoadenosine 5'-phosphosulfate Synthase 2, Sulfurylase Kinase 2, SK 2, SK2) (AP).… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PAPSS2, Polyclonal Antibody

Full Product Name

PAPSS2, NT (PAPS Synthase 2, PAPSS 2, 3'-phosphoadenosine 5'-phosphosulfate Synthase 2, ATPSK2, Bifunctional 3'-phosphoadenosine 5'-phosphosulfate Synthase 2, Sulfurylase Kinase 2, SK 2, SK2) (AP)

Product Gene Name

anti-PAPSS2 antibody

Product Synonym Names

ATP-sulfurylase; Sulfate Adenylate Transferase; Sulfate Adenylyltransferase; SAT; EC=2.7.7.4; Adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenylyl-sulfate Kinase; Adenylylsulfate; 3'-phosphotransferase; APS Kinase; 3'-phosphoadenosine-5'-phosphosulfate Synthase; EC=2.7.1.25

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

Purity/Purification

Purified by Protein G Affinity Chromatography.

Specificity

Recognizes human PAPSS2.

Preparation and Storage

May be stored at 4 degree C for short-term only. Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

70kDa

OMIM

603005

3D Structure

ModBase 3D Structure for O95340

Immunogen

Synthetic peptide selected from the N-terminal region of human PAPSS2 (KLH).

Conjugate

Note

Preservative Free

Product Categories/Family for anti-PAPSS2 antibody

Antibodies; Enzymes; Synthase

Applications Tested/Suitable for anti-PAPSS2 antibody

Immunohistochemistry (IHC), ELISA (EIA)

Application Notes for anti-PAPSS2 antibody

IHC: 1:50-1:100
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-PAPSS2 antibody

1. Xu, Z.H., et al., Biochem. Biophys. Res. Commun. 268(2):437-444 (2000). 2. Kurima, K., et al., J. Biol. Chem. 274(47):33306-33312 (1999). 3. ul Haque, M.F., et al., Nat. Genet. 20(2):157-162 (1998). 4. Kurima, K., et al., Proc. Natl. Acad. Sci. USA 95(15):8681-8685 (1998). 5. Shimizu, C., et al., Biochem. J. 363(Pt 2), 263-271 (2002).

Other Notes

Small volumes of anti-PAPSS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PAPSS2. It may not necessarily be applicable to this product.

NCBI GI #

62912492

NCBI GeneID

9060

NCBI Accession #

NP_001015880

UniProt Primary Accession #

O95340

UniProt Related Accession #

O95340

GenBank Nucleotide #

NM_001015880

NCBI Official Full Name

bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform b

NCBI Official Synonym Full Names

3'-phosphoadenosine 5'-phosphosulfate synthase 2

NCBI Official Symbol

PAPSS2

NCBI Official Synonym Symbols

SK2; BCYM4; ATPSK2

UniProt Protein Name

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

UniProt Synonym Protein Names

Sulfurylase kinase 2; SK 2; SK2

Protein Family

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase

UniProt Gene Name

PAPSS2

UniProt Synonym Gene Names

ATPSK2; PAPS synthase 2; PAPSS 2; SK 2; SK2; SAT

NCBI Protein Information

bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

NCBI Summary for PAPSS2

Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for PAPSS2

Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have a important role in skeletogenesis during postnatal growth ().

Research Articles on PAPSS2

1. Energy-dependent scoring of docking solutions identified the interaction as specific for the PAPSS2 and SULT2A1 isoforms

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PAPSS2 antibody

Reference Product	PubMed Publications
PAPSS1 antibody	>12 publications with PAPSS2 and PAPSS1
SULT1E1 antibody	>4 publications with PAPSS2 and SULT1E1
SULT1A1 antibody	>3 publications with PAPSS2 and SULT1A1

Pathways associated with anti-PAPSS2 antibody

Products by Pathway	Pathway Diagram
Biological Oxidations Pathway antibodies	Biological Oxidations Pathway Diagram
Cytosolic Sulfonation Of Small Molecules Pathway antibodies	Cytosolic Sulfonation Of Small Molecules Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Glycogen Storage Diseases Pathway antibodies	Glycogen Storage Diseases Pathway Diagram
Glycosaminoglycan Metabolism Pathway antibodies	Glycosaminoglycan Metabolism Pathway Diagram
MPS I - Hurler Syndrome Pathway antibodies	MPS I - Hurler Syndrome Pathway Diagram
MPS II - Hunter Syndrome Pathway antibodies	MPS II - Hunter Syndrome Pathway Diagram
MPS IIIA - Sanfilippo Syndrome A Pathway antibodies	MPS IIIA - Sanfilippo Syndrome A Pathway Diagram
MPS IIIB - Sanfilippo Syndrome B Pathway antibodies	MPS IIIB - Sanfilippo Syndrome B Pathway Diagram
MPS IIIC - Sanfilippo Syndrome C Pathway antibodies	MPS IIIC - Sanfilippo Syndrome C Pathway Diagram

Diseases associated with anti-PAPSS2 antibody

Disease Name	Pubmed Publications
Spondyloepimetaphyseal Dysplasia, Pakistani Type Antibodies	>3 publications with PAPSS2 and Spondyloepimetaphyseal Dysplasia, Pakistani Type
Congenital Abnormalities Antibodies	>2 publications with PAPSS2 and Congenital Abnormalities
Cholestasis Antibodies	>2 publications with PAPSS2 and Cholestasis
Disorders of Sex Development Antibodies	>1 publications with PAPSS2 and Disorders of Sex Development
Drug-Related Side Effects and Adverse Reactions Antibodies	>1 publications with PAPSS2 and Drug-Related Side Effects and Adverse Reactions
Breast Neoplasms Antibodies	>1 publications with PAPSS2 and Breast Neoplasms
Inflammation Antibodies	>1 publications with PAPSS2 and Inflammation
Kidney Diseases Antibodies	>1 publications with PAPSS2 and Kidney Diseases
Liver Diseases Antibodies	>1 publications with PAPSS2 and Liver Diseases
Fatty Liver Antibodies	>1 publications with PAPSS2 and Fatty Liver

Organs/Tissues associated with anti-PAPSS2 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>8 publications with PAPSS2 and Liver
Bone Antibodies	>8 publications with PAPSS2 and Bone
Brain Antibodies	>5 publications with PAPSS2 and Brain
Blood Antibodies	>4 publications with PAPSS2 and Blood
Kidney Antibodies	>3 publications with PAPSS2 and Kidney
Muscle Antibodies	>2 publications with PAPSS2 and Muscle
Skin Antibodies	>2 publications with PAPSS2 and Skin
Intestine Antibodies	>2 publications with PAPSS2 and Intestine
Stomach Antibodies	>2 publications with PAPSS2 and Stomach
Ovary Antibodies	>2 publications with PAPSS2 and Ovary