PARN Antibody – Rabbit Polyclonal

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

PARN: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization. Homodimer. Interacts with KHSRP and CELF1/CUGBP1. Found in a mRNA decay complex with RENT1, RENT2 and RENT3B. Ubiquitous. Belongs to the CAF1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Ribonuclease; RNA-binding; EC 3.1.13.4; Nucleolus

Chromosomal Location of Human Ortholog: 16p13

Cellular Component: cytoplasm; nucleolus; cytosol; nucleus

Molecular Function: protein binding; poly(A)-specific ribonuclease activity; nuclease activity; mRNA 3'-UTR binding; metal ion binding; nucleotide binding; protein kinase binding

Biological Process: poly(A) tail shortening; RNA modification; mRNA catabolic process, nonsense-mediated decay; female gamete generation; gene expression; mRNA catabolic process, deadenylation-dependent decay

Disease: Pulmonary Fibrosis And/or Bone Marrow Failure, Telomere-related, 4; Dyskeratosis Congenita, Autosomal Recessive, 6