PCBP1 Antibody – Rabbit Polyclonal

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

Cloke, B., et al. Endocrinology 151(8):3954-3964(2010). Wang, H., et al. Cancer Cell 18(1):52-62(2010). Zhang, T., et al. Mol. Cancer 9, 72 (2010): Waggoner, S.A., et al. J. Biol. Chem. 284(14):9039-9049(2009). Huo, L.R., et al. Biochim. Biophys. Acta 1784(11):1524-1533(2008).

Small volumes of anti-PCBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS6331337 is an antibody targeting PCBP1. Also known as PCBP1, ID (PCBP1, Poly(rC)-binding protein 1, Alpha-CP1, Heterogeneous nuclear ribonucleoprotein E1, Nucleic acid-binding protein SUB2.3) (MaxLight 550). Reactive in Human. Host: Rabbit.