Rabbit Anti-PCSK7 Polyclonal Antibody – Cat# MBS6331883

PCSK7 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PCSK7 antibody detected the PCSK7 protein (arrow).

PCSK7 Antibody – Rabbit Polyclonal

Name: PCSK7 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6331883
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6331883

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PCSK7, Polyclonal Antibody

Full Product Name

PCSK7, CT (PCSK7, LPC, PC7, PC8, SPC7, Proprotein convertase subtilisin/kexin type 7, Lymphoma proprotein convertase, Prohormone convertase 7, Proprotein convertase 7, Proprotein convertase 8, Subtilisin/kexin-like protease PC7) (FITC)

Product Gene Name

anti-PCSK7 antibody

Product Synonym Names

PCSK7; LPC; PC7; PC8; SPC7; Proprotein convertase subtilisin/kexin type 7; Lymphoma proprotein convertase; Prohormone convertase 7; Proprotein convertase 7; Proprotein convertase 8; Subtilisin/kexin-like protease PC7

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

86,247 Da

Chromosome Location

Chromosome: 11; NC_000011.9 (117075788..117102811, complement). Location: 11q23-q24

OMIM

604872

3D Structure

ModBase 3D Structure for Q16549

Immunogen

PCSK7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 691-721 amino acids from the C-terminal region of human PCSK7.

Conjugate

FITC

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-PCSK7 antibody

Antibodies; Enzymes; Protease (Proteinase; Peptidase)

Applications Tested/Suitable for anti-PCSK7 antibody

Western Blot (WB), FLISA

Application Notes for anti-PCSK7 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-PCSK7 antibody

Leonhardt, R.M., et al. J. Immunol. 184(6):2985-2998(2010). McColl, B.K., et al. FASEB J. 21(4):1088-1098(2007). Bruzzaniti, A., et al. Peptides 23(5):863-875(2002). Fugere, M., et al. J. Biol. Chem. 277(10):7648-7656(2002). Pearton, D.J., et al. Exp. Dermatol. 10(3):193-203(2001).

Other Notes

Small volumes of anti-PCSK7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PCSK7 purchase

MBS6331883 is an antibody targeting PCSK7. Also known as PCSK7, CT (PCSK7, LPC, PC7, PC8, SPC7, Proprotein convertase subtilisin/kexin type 7, Lymphoma proprotein convertase, Prohormone convertase 7, Proprotein convertase 7, Proprotein convertase 8, Subtilisin/kexin-like protease PC7) (FITC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PCSK7. It may not necessarily be applicable to this product.

NCBI GI #

20336248

NCBI GeneID

9159

NCBI Accession #

NP_004707.2

UniProt Primary Accession #

Q16549

UniProt Secondary Accession #

Q3C1X1; Q53GM4; Q96FK8; Q9UL57; B0YJ60

UniProt Related Accession #

Q16549

GenBank Nucleotide #

NM_004716.2

NCBI Official Full Name

proprotein convertase subtilisin/kexin type 7 preproprotein

NCBI Official Synonym Full Names

proprotein convertase subtilisin/kexin type 7

NCBI Official Symbol

PCSK7

NCBI Official Synonym Symbols

LPC; PC7; PC8; SPC7

UniProt Protein Name

Proprotein convertase subtilisin/kexin type 7

UniProt Synonym Protein Names

Lymphoma proprotein convertase; Prohormone convertase 7; Proprotein convertase 7; PC7; Proprotein convertase 8; PC8; hPC8; Subtilisin/kexin-like protease PC7

Protein Family

Proprotein convertase subtilisin/kexin

UniProt Gene Name

PCSK7

UniProt Synonym Gene Names

LPC; PC7; PC8; SPC7; PC7; PC8; hPC8

UniProt Entry Name

PCSK7_HUMAN

NCBI Protein Information

proprotein convertase subtilisin/kexin type 7; hPC8; prohormone convertase 7; proprotein convertase 7; proprotein convertase 8; prohormone convertase PC7; proprotein convertase PC7; lymphoma proprotein convertase; subtilisin/kexin-like protease PC7

UniProt Comments for PCSK7

Function: Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif.

Catalytic activity: Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Xaa-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys.

Cofactor: Calcium

By similarity.

Enzyme regulation: Inhibited by zinc and copper

By similarity.

Subcellular location: Golgi apparatus › trans-Golgi network membrane; Single-pass type I membrane protein

By similarity. Note: Seems to be localized intracellularly to the trans Golgi network

By similarity.

Tissue specificity: Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte.

Post-translational modification: Cysteine residues in the cytoplasmic tail are probably palmitoylated. Ref.12N-glycosylated. Ref.12

Sequence similarities: Belongs to the peptidase S8 family.Contains 1 homo B/P domain.

Research Articles on PCSK7

1. overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PCSK7 antibody

Reference Product	PubMed Publications
PCSK9 antibody	>3 publications with PCSK7 and PCSK9

Diseases associated with anti-PCSK7 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>1 publications with PCSK7 and Nervous System Diseases
Adenocarcinoma Antibodies	>1 publications with PCSK7 and Adenocarcinoma
Inflammation Antibodies	>1 publications with PCSK7 and Inflammation
Heart Diseases Antibodies	>1 publications with PCSK7 and Heart Diseases
Necrosis Antibodies	>1 publications with PCSK7 and Necrosis

Organs/Tissues associated with anti-PCSK7 antibody

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>6 publications with PCSK7 and Vascular
Kidney Antibodies	>4 publications with PCSK7 and Kidney
Embryonic Tissue Antibodies	>4 publications with PCSK7 and Embryonic Tissue
Ovary Antibodies	>4 publications with PCSK7 and Ovary
Muscle Antibodies	>4 publications with PCSK7 and Muscle
Liver Antibodies	>3 publications with PCSK7 and Liver
Nerve Antibodies	>3 publications with PCSK7 and Nerve
Blood Antibodies	>3 publications with PCSK7 and Blood
Brain Antibodies	>3 publications with PCSK7 and Brain
Heart Antibodies	>2 publications with PCSK7 and Heart