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Pd-L2/PDCD1LG2/CD273 (PDCD1LG2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2403155

CD273 antibody is an unconjugated rabbit polyclonal antibody to CD273 (PD-L2/PDCD1LG2) from human. Validated for IHC.PDCD1LG (PDL2, CD273, programmed cell death 1 ligand 2) is a ligand for the programmed death-1 receptor (PD1), which is part of the inhibitory… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PD-L2/PDCD1LG2/CD273, Polyclonal Antibody
Full Product Name
PD-L2/PDCD1LG2/CD273 Rabbit anti-Human Polyclonal Antibody
Product Gene Name
anti-PDCD1LG2 antibody
Product Synonym Names
PathPlus PD-L2/PDCD1LG2/CD273 Antibody; PDCD1LG2; B7 dendritic cell molecule; B7-DC; B7DC; BA574F11.2; CD273; Btdc; CD273 antigen; PD-L2; PDCD1 ligand 2; PD-1-ligand 2; Programmed death ligand 2; Butyrophilin B7-DC; PD-1 ligand 2; PDCD1L2; PDL2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.1% Sodium Azide
Purity/Purification
Immunoaffinity purified
Concentration
1mg/ml (lot specific)
Preparation and Storage
Aliquot and store undiluted at -20 degree C or below for up to 1 year. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze-thaw cycles.
Molecular Weight
20,745 Da
OMIM
605723
3D Structure
ModBase 3D Structure for Q9BQ51
Target
Human PD-L2/PDCD1LG2/CD273
Immunogen
LP-10667, synthetic peptide
Conjugation
Unconjugated
Applications Tested/Suitable for anti-PDCD1LG2 antibody
Immunohistochemistry-Paraffin (IHC-P)

Immunohistochemistry (IHC) of anti-PDCD1LG2 antibody

PD-L2/PDCD1LG2/CD273 Antibody-Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-PDCD1LG2 Polyclonal Antibody – Cat# MBS2403155

Immunohistochemistry (IHC) of anti-PDCD1LG2 antibody

PD-L2/PDCD1LG2/CD273 Antibody-Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-PDCD1LG2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2403155

Product References and Citations for anti-PDCD1LG2 antibody

Clin Dev Immunol 2012 ID656340; Int immunol 2010 22(*):651; Clin Can Res 2017 23(12):3158.

Other Notes

Small volumes of anti-PDCD1LG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDCD1LG2 purchase

MBS2403155 is an antibody targeting PDCD1LG2. Also known as PD-L2/PDCD1LG2/CD273 Rabbit anti-Human Polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PDCD1LG2. It may not necessarily be applicable to this product.

NCBI GI #
190014605
NCBI GeneID
80380
NCBI Accession #
NP_079515.2
UniProt Primary Accession #
Q9BQ51
UniProt Secondary Accession #
Q14CN8; Q5T7Z6; Q6JXL8; Q6JXL9
UniProt Related Accession #
Q9BQ51
GenBank Nucleotide #
NM_025239
NCBI Official Full Name
programmed cell death 1 ligand 2
NCBI Official Synonym Full Names
programmed cell death 1 ligand 2
NCBI Official Symbol
PDCD1LG2
NCBI Official Synonym Symbols
B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2
UniProt Protein Name
Programmed cell death 1 ligand 2
UniProt Synonym Protein Names
Butyrophilin B7-DC; B7-DC; CD_antigen: CD273
Protein Family
Programmed cell death
UniProt Gene Name
PDCD1LG2
UniProt Synonym Gene Names
B7DC; CD273; PDCD1L2; PDL2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; Programmed death ligand 2; B7-DC
UniProt Entry Name
PD1L2_HUMAN
NCBI Protein Information
programmed cell death 1 ligand 2

UniProt Comments for PDCD1LG2

PDCD1LG2: Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 9p24.2

Cellular Component: plasma membrane

Biological Process: negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; negative regulation of interleukin-10 production; T cell costimulation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PDCD1LG2 antibody

 Reference Product  PubMed Publications
 CD274 antibody  >204 publications with PDCD1LG2 and CD274
 PDCD1 antibody  >120 publications with PDCD1LG2 and PDCD1
 LCK antibody  >1 publications with PDCD1LG2 and LCK
 PTPN11 antibody  >1 publications with PDCD1LG2 and PTPN11

Pathways associated with anti-PDCD1LG2 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 PD-1 Signaling Pathway antibodies  PD-1 Signaling Pathway Diagram

Diseases associated with anti-PDCD1LG2 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >34 publications with PDCD1LG2 and Disease Models, Animal
 Inflammation Antibodies  >32 publications with PDCD1LG2 and Inflammation
 Carcinoma Antibodies  >21 publications with PDCD1LG2 and Carcinoma
 Neoplasms, Experimental Antibodies  >19 publications with PDCD1LG2 and Neoplasms, Experimental
 Necrosis Antibodies  >18 publications with PDCD1LG2 and Necrosis
 Lung Diseases Antibodies  >17 publications with PDCD1LG2 and Lung Diseases
 Nervous System Diseases Antibodies  >12 publications with PDCD1LG2 and Nervous System Diseases
 Adenocarcinoma Antibodies  >9 publications with PDCD1LG2 and Adenocarcinoma
 Lung Neoplasms Antibodies  >9 publications with PDCD1LG2 and Lung Neoplasms
 Cardiovascular Diseases Antibodies  >8 publications with PDCD1LG2 and Cardiovascular Diseases

Organs/Tissues associated with anti-PDCD1LG2 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >26 publications with PDCD1LG2 and Lung
 Vascular Antibodies  >9 publications with PDCD1LG2 and Vascular
 Brain Antibodies  >9 publications with PDCD1LG2 and Brain
 Heart Antibodies  >8 publications with PDCD1LG2 and Heart
 Placenta Antibodies  >4 publications with PDCD1LG2 and Placenta
 Thymus Antibodies  >2 publications with PDCD1LG2 and Thymus
 Uterus Antibodies  >2 publications with PDCD1LG2 and Uterus
 Ganglia Antibodies  >1 publications with PDCD1LG2 and Ganglia
 Testis Antibodies  >1 publications with PDCD1LG2 and Testis
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