Rabbit Anti-PDE4C Polyclonal Antibody – Cat# MBS6332153

PDE4C Antibody – Rabbit Polyclonal

Name: PDE4C Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6332153
Price: 1025 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6332153

Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular… More details

$1025 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PDE4C, Polyclonal Antibody

Full Product Name

PDE4C, NT (PDE4C, DPDE1, cAMP-specific 3',5'-cyclic phosphodiesterase 4C, PDE21) (MaxLight 750)

Product Gene Name

anti-PDE4C antibody

Product Synonym Names

PDE4C; DPDE1; cAMP-specific 3',5'-cyclic phosphodiesterase 4C; PDE21

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

79,902 Da

Chromosome Location

Chromosome: 19; NC_000019.9 (18318771..18359010, complement). Location: 19p13.11

OMIM

600128

3D Structure

ModBase 3D Structure for Q08493

Immunogen

PDE4C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-31 amino acids from the N-terminal region of human PDE4C.

Conjugate

MaxLight750

Note

Preservative Free

Product Categories/Family for anti-PDE4C antibody

Antibodies; Enzymes; Phosphodiesterase

Applications Tested/Suitable for anti-PDE4C antibody

Western Blot (WB), FLISA

Application Notes for anti-PDE4C antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-PDE4C antibody

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Davila, S., et al. Genes Immun. 11(3):232-238(2010). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004). Sullivan, M., et al. Cell. Signal. 11(10):735-742(1999).

Other Notes

Small volumes of anti-PDE4C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDE4C purchase

MBS6332153 is an antibody targeting PDE4C. Also known as PDE4C, NT (PDE4C, DPDE1, cAMP-specific 3',5'-cyclic phosphodiesterase 4C, PDE21) (MaxLight 750). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PDE4C. It may not necessarily be applicable to this product.

NCBI GI #

115529445

NCBI GeneID

5143

NCBI Accession #

NP_000914.2

UniProt Primary Accession #

Q08493

UniProt Secondary Accession #

Q9UN44; Q9UN45; Q9UN46; Q9UPJ6; B3KTC4

UniProt Related Accession #

Q08493

GenBank Nucleotide #

NM_000923.4

NCBI Official Full Name

cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform PDE4C1

NCBI Official Synonym Full Names

phosphodiesterase 4C, cAMP-specific

NCBI Official Symbol

PDE4C

NCBI Official Synonym Symbols

DPDE1

UniProt Protein Name

cAMP-specific 3',5'-cyclic phosphodiesterase 4C

UniProt Synonym Protein Names

DPDE1; PDE21

Protein Family

cAMP-specific 3',5'-cyclic phosphodiesterase

UniProt Gene Name

PDE4C

UniProt Synonym Gene Names

DPDE1

UniProt Entry Name

PDE4C_HUMAN

NCBI Protein Information

cAMP-specific 3',5'-cyclic phosphodiesterase 4C; PDE21; phosphodiesterase E1 dunce homolog; phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)

NCBI Summary for PDE4C

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

UniProt Comments for PDE4C

PDE4C: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Phosphodiesterase; Nucleotide Metabolism - purine; EC 3.1.4.53

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: extracellular space; cytosol

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; metal ion binding

Biological Process: cAMP catabolic process; signal transduction

Research Articles on PDE4C

1. PDE4A and PDE4C work in redundant fashion to mediate the loss of inhibitory PGE2 signaling in lung fibroblasts.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PDE4C antibody

Products by Pathway	Pathway Diagram
DARPP-32 Events Pathway antibodies	DARPP-32 Events Pathway Diagram
G Protein Signaling Pathways antibodies	G Protein Signaling Pathways Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
Morphine Addiction Pathway antibodies	Morphine Addiction Pathway Diagram
Morphine Addiction Pathway antibodies	Morphine Addiction Pathway Diagram
Opioid Signalling Pathway antibodies	Opioid Signalling Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram

Diseases associated with anti-PDE4C antibody

Disease Name	Pubmed Publications
Lung Diseases Antibodies	>8 publications with PDE4C and Lung Diseases
Inflammation Antibodies	>8 publications with PDE4C and Inflammation
Immune System Diseases Antibodies	>6 publications with PDE4C and Immune System Diseases
Necrosis Antibodies	>4 publications with PDE4C and Necrosis
Neoplasms Antibodies	>3 publications with PDE4C and Neoplasms
Vascular Diseases Antibodies	>2 publications with PDE4C and Vascular Diseases
Pneumonia Antibodies	>2 publications with PDE4C and Pneumonia
Kidney Diseases Antibodies	>2 publications with PDE4C and Kidney Diseases
Disease Models, Animal Antibodies	>1 publications with PDE4C and Disease Models, Animal
Proteinuria Antibodies	>1 publications with PDE4C and Proteinuria

Organs/Tissues associated with anti-PDE4C antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>8 publications with PDE4C and Muscle
Brain Antibodies	>8 publications with PDE4C and Brain
Lung Antibodies	>7 publications with PDE4C and Lung
Testis Antibodies	>3 publications with PDE4C and Testis
Embryonic Tissue Antibodies	>3 publications with PDE4C and Embryonic Tissue
Uterus Antibodies	>2 publications with PDE4C and Uterus
Eye Antibodies	>1 publications with PDE4C and Eye
Mouth Antibodies	>1 publications with PDE4C and Mouth
Placenta Antibodies	>1 publications with PDE4C and Placenta
Intestine Antibodies	>1 publications with PDE4C and Intestine