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PFKFB2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628233

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in… More details

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Product Overview

Online Datasheet in PDF
Product Name
PFKFB2, Polyclonal Antibody
Full Product Name
PFKFB2, NT (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2, 6PF-2-K/Fru-2,6-P2ase 2, PFK/FBPase 2, PFK-2/FBPase-2, 6PF-2-K/Fru-2,6-P2ase Heart-type Isozyme, DKFZp781D2217, MGC138308, MGC138310)
Product Gene Name
anti-Pfkfb2 antibody
Product Synonym Names
Anti -PFKFB2, NT (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2, 6PF-2-K/Fru-2,6-P2ase 2, PFK/FBPase 2, PFK-2/FBPase-2, 6PF-2-K/Fru-2,6-P2ase Heart-type Isozyme, DKFZp781D2217, MGC138308, MGC138310)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human PFKFB2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
59,816 Da
Chromosome Location
Chromosome: 1; NC_000067.5 (132585620..132625830, complement). Location: 1 E4; 1
3D Structure
ModBase 3D Structure for Q6GTL7
Immunogen
Synthetic peptide selected from the N-terminal region of human PFKFB2 (KLH).

Product Categories/Family for anti-Pfkfb2 antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-Pfkfb2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-Pfkfb2 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-Pfkfb2 antibody

Western blot analysis of anti-PFKFB2 Pab in mouse kidney tissue lysate (35ug/lane). PFKFB2(arrow) was detected using the purified Pab
Rabbit Anti-PFKFB2 Polyclonal Antibody – Cat# MBS628233

Immunohistochemistry (IHC) of anti-Pfkfb2 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-PFKFB2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS628233

Other Notes

Small volumes of anti-Pfkfb2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Pfkfb2 purchase

MBS628233 is an antibody targeting Pfkfb2. Also known as PFKFB2, NT (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2, 6PF-2-K/Fru-2,6-P2ase 2, PFK/FBPase 2, PFK-2/FBPase-2, 6PF-2-K/Fru-2,6-P2ase Heart-type Isozyme, DKFZp781D2217, MGC138308, MGC138310). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Pfkfb2. It may not necessarily be applicable to this product.

NCBI GI #
17390987
NCBI GeneID
18640
UniProt Primary Accession #
Q6GTL7
UniProt Related Accession #
P70265; Q6GTL7; Q8CDS6
NCBI Official Full Name
Pfkfb2 protein
NCBI Official Synonym Full Names
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
NCBI Official Symbol
Pfkfb2
NCBI Official Synonym Symbols
4930568D07Rik
UniProt Protein Name
6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 2
Protein Family
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
UniProt Gene Name
Pfkfb2
UniProt Entry Name
Q6GTL7_MOUSE
NCBI Protein Information
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2; PFK/FBPase 2; PFK-2/FBPase-2 gene B; 6PF-2-K/Fru-2,6-P2ase 2; 6PF-2-K/Fru-2,6-P2ase heart-type isozyme

UniProt Comments for Pfkfb2

PFKFB2 iso3: a bifunctional heterodimeric enzyme involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. Regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. Two splice-variant isoforms have been described.

Protein type: EC 2.7.1.105; Phosphatase (non-protein); EC 3.1.3.46; Motility/polarity/chemotaxis; Kinase, other; Carbohydrate Metabolism - fructose and mannose

Cellular Component: cytoplasm

Molecular Function: 6-phosphofructo-2-kinase activity; kinase binding; protein kinase binding

Biological Process: glucose catabolic process; glycolysis; lactate metabolic process; carbohydrate phosphorylation; response to glucose stimulus; positive regulation of insulin secretion; pyruvate metabolic process; positive regulation of glucokinase activity
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Research Articles on Pfkfb2

1. SGK3 is not required for insulin-induced PFK-2 activation and that this effect is likely mediated by PKBalpha.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Pfkfb2 antibody

 Products by Pathway  Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Glucose Metabolism Pathway antibodies  Glucose Metabolism Pathway Diagram
 Glycolysis Pathway antibodies  Glycolysis Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram

Diseases associated with anti-Pfkfb2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with Pfkfb2 and Neoplasms
 Prostatic Neoplasms Antibodies  >1 publications with Pfkfb2 and Prostatic Neoplasms
 Growth Disorders Antibodies  >1 publications with Pfkfb2 and Growth Disorders
 Brain Neoplasms Antibodies  >1 publications with Pfkfb2 and Brain Neoplasms
 Fetal Growth Retardation Antibodies  >1 publications with Pfkfb2 and Fetal Growth Retardation
 Death Antibodies  >1 publications with Pfkfb2 and Death

Organs/Tissues associated with anti-Pfkfb2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with Pfkfb2 and Blood
 Muscle Antibodies  >3 publications with Pfkfb2 and Muscle
 Heart Antibodies  >3 publications with Pfkfb2 and Heart
 Prostate Antibodies  >1 publications with Pfkfb2 and Prostate
 Lymph Node Antibodies  >1 publications with Pfkfb2 and Lymph Node
 Pancreas Antibodies  >1 publications with Pfkfb2 and Pancreas
 Embryonic Tissue Antibodies  >1 publications with Pfkfb2 and Embryonic Tissue
 Brain Antibodies  >1 publications with Pfkfb2 and Brain
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