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PHAPI2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6273849

Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A)… More details

$1025 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PHAPI2, Polyclonal Antibody
Full Product Name
PHAPI2 (Acidic Leucine-rich Nuclear Phosphoprotein 32 Family Member B, Acidic Protein Rich in Leucines, Putative HLA-DR-associated Protein I-2, ANP32B, Silver-stainable Protein SSP29, APRIL) (MaxLight 750)
Product Gene Name
anti-PHAPI2 antibody
Product Synonym Gene Name
ANP32B
Product Synonym Names
ANP32B; APRIL; PHAPI2; Acidic leucine-rich nuclear phosphoprotein 32 family member B; Acidic protein rich in leucines; Putative HLA-DR-associated protein I-2; Silver-stainable protein SSP29
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
28,788 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (100745489..100778225). Location: 9q22.32
3D Structure
ModBase 3D Structure for Q92688
Immunogen
ANP32B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human ANP32B.
Conjugate
MaxLight750
Note
Preservative Free

Product Categories/Family for anti-PHAPI2 antibody

Antibodies; Apoptosis
Applications Tested/Suitable for anti-PHAPI2 antibody
Western Blot (WB), FLISA
Application Notes for anti-PHAPI2 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-PHAPI2 antibody

Tochio, N., et al. J. Mol. Biol. 401(1):97-114(2010). Shen, S.M., et al. Carcinogenesis 31(3):419-426(2010). Chemnitz, J., et al. Eur. J. Immunol. 39(1):267-279(2009). Munemasa, Y., et al. Mol. Cell. Biol. 28(3):1171-1181(2008). Olsen, J.V., et al. Cell 127(3):635-648(2006).

Other Notes

Small volumes of anti-PHAPI2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PHAPI2 purchase

MBS6273849 is an antibody targeting PHAPI2. Also known as PHAPI2 (Acidic Leucine-rich Nuclear Phosphoprotein 32 Family Member B, Acidic Protein Rich in Leucines, Putative HLA-DR-associated Protein I-2, ANP32B, Silver-stainable Protein SSP29, APRIL) (MaxLight 750). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PHAPI2. It may not necessarily be applicable to this product.

NCBI GI #
5454088
NCBI GeneID
10541
NCBI Accession #
NP_006392.1
UniProt Primary Accession #
Q92688
UniProt Secondary Accession #
O00655; P78458; P78459; B2R9C7
UniProt Related Accession #
Q92688
GenBank Nucleotide #
NM_006401.2
NCBI Official Full Name
acidic leucine-rich nuclear phosphoprotein 32 family member B
NCBI Official Synonym Full Names
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
NCBI Official Symbol
ANP32B
NCBI Official Synonym Symbols
APRIL; SSP29; PHAPI2
UniProt Protein Name
Acidic leucine-rich nuclear phosphoprotein 32 family member B
UniProt Synonym Protein Names
Acidic protein rich in leucines; Putative HLA-DR-associated protein I-2; PHAPI2; Silver-stainable protein SSP29
UniProt Gene Name
ANP32B
UniProt Synonym Gene Names
APRIL; PHAPI2; PHAPI2
UniProt Entry Name
AN32B_HUMAN
NCBI Protein Information
acidic leucine-rich nuclear phosphoprotein 32 family member B; silver-stainable protein SSP29; acidic protein rich in leucines; putative HLA-DR-associated protein I-2

UniProt Comments for PHAPI2

ANP32B: Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity. Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome. Belongs to the ANP32 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Chaperone

Chromosomal Location of Human Ortholog: 9q22.32

Cellular Component: cytoplasm; nucleolus; nucleus

Molecular Function: histone binding

Biological Process: positive regulation of protein export from nucleus; caspase activation; nucleosome assembly; negative regulation of cell differentiation; vasculature development; ventricular system development; palate development; inner ear development
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Research Articles on PHAPI2

1. this is the first demonstration that ANP32B expression was down-regulated during differentiation induction of leukemic cells by all-trans retinoic acid.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PHAPI2 antibody

 Reference Product  PubMed Publications
 ELAVL1 antibody  >7 publications with PHAPI2 and ELAVL1

Diseases associated with anti-PHAPI2 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >29 publications with PHAPI2 and Necrosis
 Nervous System Diseases Antibodies  >4 publications with PHAPI2 and Nervous System Diseases
 Brain Diseases Antibodies  >4 publications with PHAPI2 and Brain Diseases
 Inflammation Antibodies  >4 publications with PHAPI2 and Inflammation
 Breast Neoplasms Antibodies  >1 publications with PHAPI2 and Breast Neoplasms
 Disease Models, Animal Antibodies  >1 publications with PHAPI2 and Disease Models, Animal
 Heart Diseases Antibodies  >1 publications with PHAPI2 and Heart Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with PHAPI2 and Cell Transformation, Neoplastic
 Urinary Bladder Neoplasms Antibodies  >1 publications with PHAPI2 and Urinary Bladder Neoplasms
 Hyperplasia Antibodies  >1 publications with PHAPI2 and Hyperplasia

Organs/Tissues associated with anti-PHAPI2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >25 publications with PHAPI2 and Blood
 Nerve Antibodies  >6 publications with PHAPI2 and Nerve
 Brain Antibodies  >5 publications with PHAPI2 and Brain
 Spleen Antibodies  >3 publications with PHAPI2 and Spleen
 Bone Antibodies  >2 publications with PHAPI2 and Bone
 Bone Marrow Antibodies  >2 publications with PHAPI2 and Bone Marrow
 Embryonic Tissue Antibodies  >2 publications with PHAPI2 and Embryonic Tissue
 Heart Antibodies  >1 publications with PHAPI2 and Heart
 Muscle Antibodies  >1 publications with PHAPI2 and Muscle
 Prostate Antibodies  >1 publications with PHAPI2 and Prostate
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