PKM2 (PKM) Antibody – Rabbit Polyclonal

Description: PKM2 is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. This protein has been shown to interact with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis.

Background: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

Lehner, B., et al., Genome Res. 14 (7):1315-1323 (2004). Gevaert, K., et al., Nat. Biotechnol. 21 (5):566-569 (2003). Valentini, G., et al., J. Biol. Chem. 277 (26):23807-23814 (2002). Lowrie, D.J. Jr., et al., J. Struct. Biol. 132 (2):83-94 (2000). Williams, J.M., et al., Mol. Microbiol. 27 (1):171-186 (1998).

Small volumes of anti-PKM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9217135 is an antibody targeting PKM. Also known as PKM2 Antibody (C-term L398). Reactive in Human. Host: Rabbit.