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PLCL1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9448269

PLC-L (for PLC-deleted in lung carcinoma) is a PLC family memeber, the expression of which is decreased in small cell lung carcinomas. PLC-L is normally expressed in a variety of fetal and adult organs including the lung. PLC-L is thought to be involved in… More details

$435 / 0.1 mL (Biotin) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PLCL1, Polyclonal Antibody
Full Product Name
PLCL1 Conjugated Antibody
Product Gene Name
anti-PLCL1 antibody
Product Synonym Names
PLCE; PLCL; PRIP; PLDL1; PPP1R127
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
Specificity
The antibody detects endogenous levels of total PLCL1 protein.
Preparation and Storage
Store at 4 degree C for 6 months.
OMIM
600597
3D Structure
ModBase 3D Structure for Q15111
Immunogen
Synthetic peptide corresponding to residues near the N terminal of human phospholipase C-like 1
Conjugation
Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
Excitation Emission
AF350: 346nm/442nm
Applications Tested/Suitable for anti-PLCL1 antibody
Most Applications
Application Notes for anti-PLCL1 antibody
Suggested Dilution:
AF350 conjugated: most applications: 1:50-1:250
AF405 conjugated: most applications: 1:50-1:250
AF488 conjugated: most applications: 1:50-1:250
AF555 conjugated: most applications: 1:50-1:250
AF594 conjugated: most applications: 1:50-1:250
AF647 conjugated: most applications: 1:50-1:250
AF680 conjugated: most applications: 1:50-1:250
AF750 conjugated: most applications: 1:50-1:250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000

Other Notes

Small volumes of anti-PLCL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLCL1 purchase

MBS9448269 is an antibody targeting PLCL1. Also known as PLCL1 Conjugated Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PLCL1. It may not necessarily be applicable to this product.

NCBI GI #
11386139
NCBI GeneID
5331
NCBI Accession #
NP_000923
UniProt Primary Accession #
Q15111
UniProt Secondary Accession #
Q01970
UniProt Related Accession #
Q01970
GenBank Nucleotide #
NP_000923.1
NCBI Official Full Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform 1
NCBI Official Synonym Full Names
phospholipase C beta 3
NCBI Official Symbol
PLCB3
UniProt Protein Name
Inactive phospholipase C-like protein 1
UniProt Synonym Protein Names
Phospholipase C-deleted in lung carcinoma; Phospholipase C-related but catalytically inactive protein; PRIP
Protein Family
Inactive phospholipase C-like protein
UniProt Gene Name
PLCL1
UniProt Synonym Gene Names
PLC-L1; PRIP
UniProt Entry Name
PLCL1_HUMAN
NCBI Protein Information
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

NCBI Summary for PLCL1

This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
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UniProt Comments for PLCL1

PLCL1: a protein closely related to phospholipase C-d1 (PLC-d1) but catalytically inactive. First identified as a novel inositol 1,4,5-trisphosphate binding protein. Has a number of binding partners including protein phosphatase (PP1 and 2A), GABA(A) receptor associated protein, and the beta subunits of GABA(A) receptors, in addition to inositol 1,4,5-trisphosphate. Plays an important role in controlling the dynamics of GABA(A) receptor phosphorylation through PP1 binding and, therefore, the efficacy of synaptic inhibition mediated by these receptors.

Protein type: Phospholipase

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: cytoplasm; plasma membrane

Molecular Function: signal transducer activity; GABA receptor binding; phosphoinositide phospholipase C activity; phospholipase C activity

Biological Process: regulation of peptidyl-serine phosphorylation; lipid metabolic process; regulation of synaptic transmission, GABAergic; gamma-aminobutyric acid signaling pathway
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Research Articles on PLCL1

1. A homozygous loss of function variant in PLCB3 is associated with corneal dystrophy, developmental delay and spondylometaphyseal dysplasia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PLCL1 antibody

 Reference Product  PubMed Publications
 PARD3 antibody  >1 publications with PLCL1 and PARD3

Pathways associated with anti-PLCL1 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Kainate Receptors Upon Glutamate Binding Pathway antibodies  Activation Of Kainate Receptors Upon Glutamate Binding Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram

Diseases associated with anti-PLCL1 antibody

 Disease Name  Pubmed Publications
 Pain Antibodies  >5 publications with PLCL1 and Pain
 Cardiovascular Diseases Antibodies  >5 publications with PLCL1 and Cardiovascular Diseases
 Inflammation Antibodies  >4 publications with PLCL1 and Inflammation
 Heart Diseases Antibodies  >3 publications with PLCL1 and Heart Diseases
 Cardiomegaly Antibodies  >2 publications with PLCL1 and Cardiomegaly
 Hypertrophy, Left Ventricular Antibodies  >2 publications with PLCL1 and Hypertrophy, Left Ventricular
 Hypertrophy Antibodies  >2 publications with PLCL1 and Hypertrophy
 Congenital Abnormalities Antibodies  >2 publications with PLCL1 and Congenital Abnormalities
 Death Antibodies  >1 publications with PLCL1 and Death
 Hyperalgesia Antibodies  >1 publications with PLCL1 and Hyperalgesia

Organs/Tissues associated with anti-PLCL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >16 publications with PLCL1 and Brain
 Lung Antibodies  >5 publications with PLCL1 and Lung
 Uterus Antibodies  >3 publications with PLCL1 and Uterus
 Connective Tissue Antibodies  >2 publications with PLCL1 and Connective Tissue
 Bone Antibodies  >2 publications with PLCL1 and Bone
 Embryonic Tissue Antibodies  >2 publications with PLCL1 and Embryonic Tissue
 Skin Antibodies  >2 publications with PLCL1 and Skin
 Kidney Antibodies  >2 publications with PLCL1 and Kidney
 Testis Antibodies  >1 publications with PLCL1 and Testis
 Intestine Antibodies  >1 publications with PLCL1 and Intestine
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