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PLEKHA1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8570688

This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PLEKHA1, Polyclonal Antibody
Full Product Name
PLEKHA1 Polyclonal Antibody
Product Gene Name
anti-PLEKHA1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
38kDa; 45kDa
OMIM
AF286160 mRNA
3D Structure
ModBase 3D Structure for Q9HB21
Immunogen
Recombinant protein of human PLEKHA1 (NP_067635.2).
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PLEKHA1 antibody
Immunofluorescence (IF)
Application Notes for anti-PLEKHA1 antibody
IF: 1:50-1:200

Other Notes

Small volumes of anti-PLEKHA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLEKHA1 purchase

MBS8570688 is an antibody targeting PLEKHA1. Also known as PLEKHA1 Polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PLEKHA1. It may not necessarily be applicable to this product.

NCBI GI #
50234893
NCBI GeneID
59338
NCBI Accession #
NP_001001974.1
UniProt Primary Accession #
Q9HB21
UniProt Related Accession #
Q9HB21
GenBank Nucleotide #
NP_001001974.1
NCBI Official Full Name
pleckstrin homology domain-containing family A member 1 isoform 1
NCBI Official Synonym Full Names
pleckstrin homology domain containing A1
NCBI Official Symbol
PLEKHA1
NCBI Official Synonym Symbols
TAPP1
UniProt Protein Name
Pleckstrin homology domain-containing family A member 1
UniProt Synonym Protein Names
Tandem PH domain-containing protein 1; TAPP-1
Protein Family
Pleckstrin homology domain-containing family
UniProt Gene Name
PLEKHA1
UniProt Synonym Gene Names
TAPP1; PH domain-containing family A member 1; TAPP-1
NCBI Protein Information
pleckstrin homology domain-containing family A member 1

UniProt Comments for PLEKHA1

PLEKHA1: Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 10q26.13

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane

Molecular Function: PDZ domain binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding

Biological Process: androgen metabolic process; B cell receptor signaling pathway; establishment of protein localization; estrogen metabolic process; Leydig cell differentiation; luteinization; multicellular organism growth; negative regulation of protein kinase B signaling cascade; palate development; phosphatidylinositol biosynthetic process; phosphoinositide 3-kinase cascade; platelet-derived growth factor receptor signaling pathway; post-embryonic development; ruffle organization; skeletal morphogenesis; spermatogenesis

Disease: Macular Degeneration, Age-related, 1
Show more

Research Articles on PLEKHA1

1. investigated the association of PLEKHA1 958A/G, polymorphisms with Age-Related Macular Degeneration (AMD) risk. PLEKHA1 958A/G polymorphism was associated with a decreased AMD risk (additive model: aOR=0.722, 95% CI=0.450-0.979, P=0.019; allele model: aOR=0.883, 95% CI=0.736-0.992, P=0.014)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PLEKHA1 antibody

 Reference Product  PubMed Publications
 HTRA1 antibody  >15 publications with PLEKHA1 and HTRA1
 CFH antibody  >14 publications with PLEKHA1 and CFH
 PLEKHA2 antibody  >5 publications with PLEKHA1 and PLEKHA2
 HMCN1 antibody  >2 publications with PLEKHA1 and HMCN1
 ELOVL4 antibody  >1 publications with PLEKHA1 and ELOVL4
 PTPN13 antibody  >1 publications with PLEKHA1 and PTPN13
 MPDZ antibody  >1 publications with PLEKHA1 and MPDZ

Pathways associated with anti-PLEKHA1 antibody

 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram

Diseases associated with anti-PLEKHA1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with PLEKHA1 and Nervous System Diseases
 Kidney Diseases Antibodies  >1 publications with PLEKHA1 and Kidney Diseases

Organs/Tissues associated with anti-PLEKHA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with PLEKHA1 and Brain
 Embryonic Tissue Antibodies  >2 publications with PLEKHA1 and Embryonic Tissue
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