PLSCR1 Antibody – Rabbit Polyclonal

PLSCR1: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Belongs to the phospholipid scramblase family.

Protein type: Calcium-binding; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q23

Cellular Component: cytosol; extracellular matrix; Golgi apparatus; integral to plasma membrane; lipid raft; membrane; nucleolus; nucleus; plasma membrane

Molecular Function: calcium ion binding; CD4 receptor binding; enzyme binding; epidermal growth factor receptor binding; phospholipid scramblase activity; protein binding; SH3 domain binding

Biological Process: acute-phase response; apoptosis; defense response to virus; negative regulation of viral genome replication; phosphatidylserine biosynthetic process; phospholipid scrambling; positive regulation of innate immune response; positive regulation of transcription from RNA polymerase II promoter; regulation of mast cell activation