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PNPLA8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6335427

PNPLA8 catalyzes cleavage of fatty acids from phospholipids, thereby regulating membrane physical properties and the release of lipid second messengers and growth factors. Phospholipase A2 activity also modulates cellular growth programs, inflammation, and… More details

$1025 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PNPLA8, Polyclonal Antibody
Full Product Name
PNPLA8, NT (PNPLA8, IPLA22, IPLA2G, Calcium-independent phospholipase A2-gamma, Intracellular membrane-associated calcium-independent phospholipase A2 gamma, PNPLA-gamma, Patatin-like phospholipase domain-containing protein 8, iPLA2-2) (MaxLight 405)
Product Gene Name
anti-PNPLA8 antibody
Product Synonym Names
PNPLA8; IPLA22; IPLA2G; Calcium-independent phospholipase A2-gamma; Intracellular membrane-associated calcium-independent phospholipase A2 gamma; PNPLA-gamma; Patatin-like phospholipase domain-containing protein 8; iPLA2-2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
88,477 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (108110866..108168605, complement). Location: 7q31
OMIM
612123
3D Structure
ModBase 3D Structure for Q9NP80
Immunogen
PNPLA8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 219~248 amino acids from the N-terminal region of human PNPLA8.
Conjugate
MaxLight405
Note
Preservative Free

Product Categories/Family for anti-PNPLA8 antibody

Antibodies; Enzymes; Phospholipase
Applications Tested/Suitable for anti-PNPLA8 antibody
Flow Cytometry (FC/FACS), FLISA, Western Blot (WB)
Application Notes for anti-PNPLA8 antibody
FC/FACS: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-PNPLA8 antibody

Harper, M.T., et al. J. Thromb. Haemost. 6(10):1819-1821(2008). Wilson, P.A., et al. J. Lipid Res. 47(9):1940-1949(2006). Murakami, M., et al. J. Biol. Chem. 280(14):14028-14041(2005).

Other Notes

Small volumes of anti-PNPLA8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PNPLA8 purchase

MBS6335427 is an antibody targeting PNPLA8. Also known as PNPLA8, NT (PNPLA8, IPLA22, IPLA2G, Calcium-independent phospholipase A2-gamma, Intracellular membrane-associated calcium-independent phospholipase A2 gamma, PNPLA-gamma, Patatin-like phospholipase domain-containing protein 8, iPLA2-2) (MaxLight 405). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PNPLA8. It may not necessarily be applicable to this product.

NCBI GI #
365192573
NCBI GeneID
50640
NCBI Accession #
NP_001242936.1
UniProt Primary Accession #
Q9NP80
UniProt Secondary Accession #
O95035; Q8N3I3; Q9H7T5; Q9NR17; Q9NUN2; Q9NZ79; A4D0S1; C9JZI4
UniProt Related Accession #
Q9NP80
GenBank Nucleotide #
NM_001256007.1
NCBI Official Full Name
calcium-independent phospholipase A2-gamma isoform 1
NCBI Official Synonym Full Names
patatin-like phospholipase domain containing 8
NCBI Official Symbol
PNPLA8
NCBI Official Synonym Symbols
IPLA2G; IPLA2-2; iPLA2gamma; IPLA2(GAMMA)
UniProt Protein Name
Calcium-independent phospholipase A2-gamma
UniProt Synonym Protein Names
Intracellular membrane-associated calcium-independent phospholipase A2 gamma; iPLA2-gamma; PNPLA-gamma; Patatin-like phospholipase domain-containing protein 8; iPLA2-2
Protein Family
Calcium-independent phospholipase
UniProt Gene Name
PNPLA8
UniProt Synonym Gene Names
IPLA22; IPLA2G; iPLA2-gamma
UniProt Entry Name
PLPL8_HUMAN
NCBI Protein Information
calcium-independent phospholipase A2-gamma; PNPLA-gamma; iPLA2 gamma; iPLA2-gamma; patatin-like phospholipase domain-containing protein 8; membrane-associated calcium-independent phospholipase A2 gamma; intracellular membrane-associated calcium-independen

NCBI Summary for PNPLA8

This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. A pseudogene of this gene is located on the X chromosome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
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UniProt Comments for PNPLA8

PNPLA8: Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Phospholipase; Membrane protein, integral; EC 3.1.1.5

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: Golgi membrane; peroxisomal membrane; endoplasmic reticulum membrane; membrane; perinuclear region of cytoplasm; integral to membrane; peroxisome; intracellular

Molecular Function: calcium-independent phospholipase A2 activity; ATP binding; lysophospholipase activity

Biological Process: cell death; phosphatidylethanolamine catabolic process; phospholipid metabolic process; glycerophospholipid biosynthetic process; arachidonic acid metabolic process; linoleic acid metabolic process; fatty acid metabolic process; prostaglandin biosynthetic process; arachidonic acid secretion

Disease: Mitochondrial Myopathy With Lactic Acidosis
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Research Articles on PNPLA8

1. Thus, complement-mediated activation of iPLA(2)gamma is mediated via ERK and p38 pathways, and phosphorylation of Ser-511 and/or Ser-515 plays a key role in the catalytic activity and signaling of iPLA(2)gamma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PNPLA8 antibody

 Products by Pathway  Pathway Diagram
 Acyl Chain Remodelling Of PC Pathway antibodies  Acyl Chain Remodelling Of PC Pathway Diagram
 Acyl Chain Remodelling Of PE Pathway antibodies  Acyl Chain Remodelling Of PE Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 Glycerophospholipid Biosynthesis Pathway antibodies  Glycerophospholipid Biosynthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Phospholipid Metabolism Pathway antibodies  Phospholipid Metabolism Pathway Diagram
 Phospholipases Pathway antibodies  Phospholipases Pathway Diagram

Organs/Tissues associated with anti-PNPLA8 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >1 publications with PNPLA8 and Heart
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