Rabbit Anti-PPM1A Polyclonal Antibody – Cat# MBS6336370

PPM1A Antibody (pS) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the PPM1A antibody detected the PPM1A protein (arrow).

PPM1A Antibody – Rabbit Polyclonal

Name: PPM1A Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6336370
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6336370

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PPM1A, Polyclonal Antibody

Full Product Name

PPM1A (PPM1A, PPPM1A, Protein phosphatase 1A, Protein phosphatase 2C isoform alpha, Protein phosphatase IA) (Biotin)

Product Gene Name

anti-PPM1A antibody

Product Synonym Names

PPM1A; PPPM1A; Protein phosphatase 1A; Protein phosphatase 2C isoform alpha; Protein phosphatase IA

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

382

Chromosome Location

Chromosome: 14; NC_000014.8 (60712470..60765805). Location: 14q23.1

OMIM

606108

3D Structure

ModBase 3D Structure for P35813

Immunogen

PPM1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from human PPM1A.

Conjugate

Biotin

Note

Preservative Free

Product Categories/Family for anti-PPM1A antibody

Antibodies; Enzymes; Phosphatase

Applications Tested/Suitable for anti-PPM1A antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-PPM1A antibody

WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-PPM1A antibody

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Zhang, B., et al. Histochem. Cell Biol. 132(2):169-179(2009). Sun, W., et al. Cell. Signal. 21(1):95-102(2009). Wang, Y., et al. J. Biol. Chem. 283(48):33578-33584(2008). Bu, S., et al. J. Biol. Chem. 283(28):19593-19602(2008).

Other Notes

Small volumes of anti-PPM1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPM1A purchase

MBS6336370 is an antibody targeting PPM1A. Also known as PPM1A (PPM1A, PPPM1A, Protein phosphatase 1A, Protein phosphatase 2C isoform alpha, Protein phosphatase IA) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PPM1A. It may not necessarily be applicable to this product.

NCBI GI #

10337595

NCBI GeneID

5494

NCBI Accession #

NP_066283.1

NCBI Related Accession #

NP_808820.1

UniProt Primary Accession #

P35813

UniProt Secondary Accession #

O75551; B5BU11; J3KNM0

UniProt Related Accession #

P35813

GenBank Nucleotide #

NM_021003.4

NCBI Official Full Name

protein phosphatase 1A isoform 1

NCBI Official Synonym Full Names

protein phosphatase, Mg2+/Mn2+ dependent, 1A

NCBI Official Symbol

PPM1A

NCBI Official Synonym Symbols

PP2CA; PP2Calpha; PP2C-ALPHA

UniProt Protein Name

Protein phosphatase 1A

UniProt Synonym Protein Names

Protein phosphatase 2C isoform alpha; PP2C-alpha; Protein phosphatase IA

Protein Family

Protein phosphatase

UniProt Gene Name

PPM1A

UniProt Synonym Gene Names

PPPM1A; PP2C-alpha

UniProt Entry Name

PPM1A_HUMAN

NCBI Protein Information

protein phosphatase 1A; protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform

UniProt Comments for PPM1A

PPPM1A: a Ser/Thr protein phosphatase of the PP2C family. Inhibits the activation of p38 and JNK kinase cascades induced by environmental stresses. Can also dephosphorylate cyclin-dependent kinases and may play a role in cell cycle control. Overexpression of this phosphatase activates the expression of p53, leading to G2/M cell cycle arrest and apoptosis.

Protein type: Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16

Chromosomal Location of Human Ortholog: 14q23.1

Cellular Component: nucleoplasm; neuron projection; membrane; voltage-gated calcium channel complex; nucleus; cytosol

Molecular Function: protein C-terminus binding; protein binding; signal transducer activity; calmodulin-dependent protein phosphatase activity; manganese ion binding; magnesium ion binding; protein serine/threonine phosphatase activity

Biological Process: transcription initiation from RNA polymerase II promoter; N-terminal protein myristoylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; Wnt receptor signaling pathway; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; negative regulation of NF-kappaB import into nucleus; negative regulation of I-kappaB kinase/NF-kappaB cascade; protein amino acid dephosphorylation; dephosphorylation; transforming growth factor beta receptor signaling pathway; insulin receptor signaling pathway; gene expression; cell cycle arrest; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of Wnt receptor signaling pathway

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PPM1A antibody

Reference Product	PubMed Publications
SMAD2 antibody	>11 publications with PPM1A and SMAD2
CDK9 antibody	>2 publications with PPM1A and CDK9
SMAD5 antibody	>2 publications with PPM1A and SMAD5
SMAD4 antibody	>1 publications with PPM1A and SMAD4

Pathways associated with anti-PPM1A antibody

Products by Pathway	Pathway Diagram
BMP Receptor Signaling Pathway antibodies	BMP Receptor Signaling Pathway Diagram
Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway antibodies	Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway Diagram
Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway antibodies	Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
IGF1R Signaling Cascade Pathway antibodies	IGF1R Signaling Cascade Pathway Diagram
IRS-mediated Signalling Pathway antibodies	IRS-mediated Signalling Pathway Diagram
IRS-related Events Pathway antibodies	IRS-related Events Pathway Diagram
IRS-related Events Triggered By IGF1R Pathway antibodies	IRS-related Events Triggered By IGF1R Pathway Diagram
Insulin Receptor Signalling Cascade Pathway antibodies	Insulin Receptor Signalling Cascade Pathway Diagram

Diseases associated with anti-PPM1A antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>5 publications with PPM1A and Neoplasms
Necrosis Antibodies	>3 publications with PPM1A and Necrosis
Fibrosis Antibodies	>3 publications with PPM1A and Fibrosis
Kidney Diseases Antibodies	>2 publications with PPM1A and Kidney Diseases
Adenocarcinoma Antibodies	>1 publications with PPM1A and Adenocarcinoma
Carcinoma Antibodies	>1 publications with PPM1A and Carcinoma
Depressive Disorder Antibodies	>1 publications with PPM1A and Depressive Disorder
Cardiovascular Diseases Antibodies	>1 publications with PPM1A and Cardiovascular Diseases
Carcinoma, Hepatocellular Antibodies	>1 publications with PPM1A and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>1 publications with PPM1A and Liver Neoplasms

Organs/Tissues associated with anti-PPM1A antibody

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>4 publications with PPM1A and Embryonic Tissue
Bone Antibodies	>4 publications with PPM1A and Bone
Kidney Antibodies	>2 publications with PPM1A and Kidney
Placenta Antibodies	>2 publications with PPM1A and Placenta
Liver Antibodies	>2 publications with PPM1A and Liver
Muscle Antibodies	>2 publications with PPM1A and Muscle
Connective Tissue Antibodies	>2 publications with PPM1A and Connective Tissue
Vascular Antibodies	>2 publications with PPM1A and Vascular
Brain Antibodies	>2 publications with PPM1A and Brain
Stomach Antibodies	>1 publications with PPM1A and Stomach