PPP1R16B Antibody – Rabbit Polyclonal

The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]

PPP1R16B: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.

Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 20q11.23

Cellular Component: cell projection; nucleus; perinuclear region of cytoplasm; plasma membrane

Molecular Function: protein binding; protein phosphatase type 1 regulator activity

Biological Process: negative regulation of protein amino acid dephosphorylation; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid dephosphorylation; regulation of catalytic activity; regulation of filopodium formation; regulation of phosphoinositide 3-kinase cascade