Rabbit Anti-PRDM6 Polyclonal Antibody – Cat# MBS6337093

PRDM6 Antibody (N-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the PRDM6 antibody detected the PRDM6 protein (arrow).

PRDM6 Antibody – Rabbit Polyclonal

Name: PRDM6 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6337093
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6337093

Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PRDM6, Polyclonal Antibody

Full Product Name

PRDM6, NT (PRDM6, PFM3, Putative histone-lysine N-methyltransferase PRDM6, PR domain zinc finger protein 6, PR domain-containing protein 6) (PE)

Product Gene Name

anti-PRDM6 antibody

Product Synonym Names

PRDM6; PFM3; Putative histone-lysine N-methyltransferase PRDM6; PR domain zinc finger protein 6; PR domain-containing protein 6

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

46,635 Da

OMIM

AF272898 mRNA

3D Structure

ModBase 3D Structure for Q9NQX0

Immunogen

PRDM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-72 amino acids from the N-terminal region of human PRDM6.

Conjugate

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-PRDM6 antibody

Antibodies; Enzymes; Methyltransferase

Applications Tested/Suitable for anti-PRDM6 antibody

Western Blot (WB), FLISA

Application Notes for anti-PRDM6 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-PRDM6 antibody

Rose, J. Phd, et al. Mol. Med. (2010). In press: Vasan, R.S., et al. JAMA 302(2):168-178(2009).

Other Notes

Small volumes of anti-PRDM6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRDM6 purchase

MBS6337093 is an antibody targeting PRDM6. Also known as PRDM6, NT (PRDM6, PFM3, Putative histone-lysine N-methyltransferase PRDM6, PR domain zinc finger protein 6, PR domain-containing protein 6) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PRDM6. It may not necessarily be applicable to this product.

NCBI GI #

210031233

NCBI GeneID

93166

NCBI Accession #

NP_001129711.1

UniProt Primary Accession #

Q9NQX0

UniProt Secondary Accession #

Q9NQW9; B5MCJ4

UniProt Related Accession #

Q9NQX0

GenBank Nucleotide #

NM_001136239.3

NCBI Official Full Name

putative histone-lysine N-methyltransferase PRDM6

NCBI Official Synonym Full Names

PR/SET domain 6

NCBI Official Symbol

PRDM6

NCBI Official Synonym Symbols

PDA3; KMT8C; PRISM

UniProt Protein Name

Putative histone-lysine N-methyltransferase PRDM6

UniProt Synonym Protein Names

PR domain zinc finger protein 6; PR domain-containing protein 6

Protein Family

Putative histone-lysine N-methyltransferase

UniProt Gene Name

PRDM6

UniProt Synonym Gene Names

PFM3

NCBI Protein Information

putative histone-lysine N-methyltransferase PRDM6

NCBI Summary for PRDM6

The protein encoded by this gene is a transcriptional repressor and a member of the PRDM family. Family members contain a PR domain and multiple zinc-finger domains. The encoded protein is involved in regulation of vascular smooth muscle cells (VSMC) contractile proteins. Mutations in this gene result in patent ductus arteriosus 3 (PDA3). [provided by RefSeq, Apr 2017]

UniProt Comments for PRDM6

PRDM6: Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; Cell development/differentiation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 5q23.2

Cellular Component: nucleus

Molecular Function: histone-lysine N-methyltransferase activity; metal ion binding; nucleic acid binding; protein homodimerization activity

Biological Process: negative regulation of smooth muscle cell differentiation; negative regulation of transcription, DNA-dependent; neurogenesis; transcription, DNA-dependent

Disease: Patent Ductus Arteriosus 3

Research Articles on PRDM6

1. Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-PRDM6 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>1 publications with PRDM6 and Brain
Heart Antibodies	>1 publications with PRDM6 and Heart
Uncharacterized Tissue Antibodies	>1 publications with PRDM6 and Uncharacterized Tissue