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PRDM8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6337103

MBS6337103 is an antibody targeting PRDM8. Also known as PRDM8, NT (PRDM8, PFM5, PR domain zinc finger protein 8, PR domain-containing protein 8) (MaxLight 750). Reactive in Human. Host: Rabbit. PRDM8 may be involved in transcriptional regulation. More details

$1025 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PRDM8, Polyclonal Antibody
Full Product Name
PRDM8, NT (PRDM8, PFM5, PR domain zinc finger protein 8, PR domain-containing protein 8) (MaxLight 750)
Product Gene Name
anti-PRDM8 antibody
Product Synonym Names
PRDM8; PFM5; PR domain zinc finger protein 8; PR domain-containing protein 8
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
35,470 Da
3D Structure
ModBase 3D Structure for Q9NQV8
Immunogen
PRDM8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-102 amino acids from the N-terminal region of human PRDM8.
Conjugate
MaxLight750
Note
Preservative Free

Product Categories/Family for anti-PRDM8 antibody

Antibodies; Transcription Factors; Zinc (Ring) Finger
Applications Tested/Suitable for anti-PRDM8 antibody
Western Blot (WB), FLISA
Application Notes for anti-PRDM8 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-PRDM8 antibody

Newton-Cheh, C., et al. Nat. Genet. (2009). In press: Xiao, B., et al. Curr. Opin. Struct. Biol. 13(6):699-705(2003). Jiang, G.L., et al. Histol. Histopathol. 15(1):109-117(2000).

Other Notes

Small volumes of anti-PRDM8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PRDM8. It may not necessarily be applicable to this product.

NCBI GI #
150378478
NCBI GeneID
56978
NCBI Accession #
NP_001092873.1
NCBI Related Accession #
NP_064611.3
UniProt Primary Accession #
Q9NQV8
UniProt Secondary Accession #
Q6IQ36; A8K7X2
UniProt Related Accession #
Q9NQV8
GenBank Nucleotide #
NM_001099403.1
NCBI Official Full Name
PR domain zinc finger protein 8
NCBI Official Synonym Full Names
PR/SET domain 8
NCBI Official Symbol
PRDM8
NCBI Official Synonym Symbols
PFM5; EPM10; KMT8D
UniProt Protein Name
PR domain zinc finger protein 8
UniProt Synonym Protein Names
PR domain-containing protein 8
Protein Family
PR domain zinc finger protein
UniProt Gene Name
PRDM8
UniProt Synonym Gene Names
PFM5
UniProt Entry Name
PRDM8_HUMAN
NCBI Protein Information
PR domain zinc finger protein 8

NCBI Summary for PRDM8

This gene encodes a protein that belongs to a conserved family of histone methyltransferases that predominantly act as negative regulators of transcription. The encoded protein contains an N-terminal Su(var)3-9, Enhancer-of-zeste, and Trithorax (SET) domain and a double zinc-finger domain. Knockout of this gene in mouse results in mistargeting by neurons of the dorsal telencephalon, abnormal itch-like behavior, and impaired differentiation of rod bipolar cells. In humans, the protein has been shown to interact with the phosphatase laforin and the ubiquitin ligase malin, which regulate glycogen construction in the cytoplasm. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
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Research Articles on PRDM8

1. Aberrant hypermethylation is particularly observed in PRDM8 and this may support identification and classification of bone marrow failure syndromes

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PRDM8 antibody

 Reference Product  PubMed Publications
 C4orf22 antibody  >1 publications with PRDM8 and C4orf22

Pathways associated with anti-PRDM8 antibody

 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 PKMTs Methylate Histone Lysines Pathway antibodies  PKMTs Methylate Histone Lysines Pathway Diagram

Diseases associated with anti-PRDM8 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >2 publications with PRDM8 and Brain Diseases

Organs/Tissues associated with anti-PRDM8 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with PRDM8 and Brain
 Blood Antibodies  >1 publications with PRDM8 and Blood
 Testis Antibodies  >1 publications with PRDM8 and Testis
 Skin Antibodies  >1 publications with PRDM8 and Skin
 Heart Antibodies  >1 publications with PRDM8 and Heart
 Eye Antibodies  >1 publications with PRDM8 and Eye
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