Rabbit Anti-PRKG2 Polyclonal Antibody – Cat# MBS6495321

PRKG2 Antibody – Rabbit Polyclonal

Name: PRKG2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6495321
Price: 1025 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6495321

MBS6495321 is an antibody targeting PRKG2. Also known as PRKG2, CT (cGMP-dependent Protein Kinase 2, cGK 2, cGK2, cGMP-dependent Protein Kinase II, cGKII, PRKGR2) (MaxLight 750). Reactive in Human. Host: Rabbit. More details

$1025 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PRKG2, Polyclonal Antibody

Full Product Name

PRKG2, CT (cGMP-dependent Protein Kinase 2, cGK 2, cGK2, cGMP-dependent Protein Kinase II, cGKII, PRKGR2) (MaxLight 750)

Product Gene Name

anti-PRKG2 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

Purity/Purification

Purified by Protein G Affinity Chromatography.

Specificity

Recognizes human cGKII.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

87,432 Da

Chromosome Location

Chromosome: 4; NC_000004.11 (82009837..82126215, complement). Location: 4q13.1-q21.1

OMIM

601591

3D Structure

ModBase 3D Structure for Q13237

Immunogen

Synthetic peptide selected from the C-terminal region of human cGKII (KLH).

Conjugate

MaxLight750

Note

Preservative Free

Product Categories/Family for anti-PRKG2 antibody

Antibodies; Protein Kinase Substrates

Applications Tested/Suitable for anti-PRKG2 antibody

Immunohistochemistry (IHC), FLISA, Western Blot (WB)

Application Notes for anti-PRKG2 antibody

IHC: 1:50-1:100
FLISA: 1:1,000
WB: 1:100-1:500
Applications are based on unconjugated antibody.

Product References and Citations for anti-PRKG2 antibody

1. Vaandrager, A.B., et al., J. Biol. Chem. 278(31):28651-28658 (2003). 2. Gambaryan, S., et al., Biochem. Biophys. Res. Commun. 293(5):1438-1444 (2002). 3. Orstavik, S., et al., Biochem. Biophys. Res. Commun. 220(3):759-765 (1996). 4. Fujii, M., et al., FEBS Lett. 375(3):263-267 (1995). 5. Hema Rangaswami, et al. J. Biol. Chem., Vol. 284, Issue 22, 14796-14808. (Applications: WB).

Other Notes

Small volumes of anti-PRKG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PRKG2. It may not necessarily be applicable to this product.

NCBI GI #

5453978

NCBI GeneID

5593

NCBI Accession #

NP_006250.1

UniProt Primary Accession #

Q13237

UniProt Secondary Accession #

O00125; O60916

UniProt Related Accession #

Q13237

GenBank Nucleotide #

NM_006259.1

NCBI Official Full Name

cGMP-dependent protein kinase 2

NCBI Official Synonym Full Names

protein kinase, cGMP-dependent, type II

NCBI Official Symbol

PRKG2

NCBI Official Synonym Symbols

cGKII; PRKGR2

UniProt Protein Name

cGMP-dependent protein kinase 2

UniProt Synonym Protein Names

cGMP-dependent protein kinase II

Protein Family

cGMP-dependent protein kinase

UniProt Gene Name

PRKG2

UniProt Synonym Gene Names

PRKGR2; cGK 2; cGK2; cGKII

UniProt Entry Name

KGP2_HUMAN

NCBI Protein Information

cGMP-dependent protein kinase 2; cGK2; cGK 2; cGMP-dependent protein kinase II

NCBI Summary for PRKG2

This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

UniProt Comments for PRKG2

PKG2: an AGC kinase of the PKG family. Type II cGMP-dependent protein kinase is expressed at high levels in brain, lung and intestinal mucosa.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.12; Kinase, protein; Protein kinase, AGC; AGC group; PKG family

Chromosomal Location of Human Ortholog: 4q13.1-q21.1

Cellular Component: nuclear membrane; apical plasma membrane; cytosol

Molecular Function: protein homodimerization activity; cGMP-dependent protein kinase activity; cGMP binding; ATP binding; protein kinase activity

Biological Process: circadian regulation of gene expression; regulation of nitric-oxide synthase activity; signal transduction; blood coagulation; protein amino acid phosphorylation; nitric oxide metabolic process

Research Articles on PRKG2

1. type II cGMPdependent protein kinase prevented the EGF-induced phosphorylation/activation of ERK and JNK, but not the phosphorylation of p38MAPK induced by EGF.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PRKG2 antibody

Reference Product	PubMed Publications
MYLK antibody	>1 publications with PRKG2 and MYLK

Pathways associated with anti-PRKG2 antibody

Products by Pathway	Pathway Diagram
Circadian Entrainment Pathway antibodies	Circadian Entrainment Pathway Diagram
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Gap Junction Pathway antibodies	Gap Junction Pathway Diagram
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Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Long-term Depression Pathway antibodies	Long-term Depression Pathway Diagram
Long-term Depression Pathway antibodies	Long-term Depression Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Nitric Oxide Pathway antibodies	Metabolism Of Nitric Oxide Pathway Diagram
Nitric Oxide Stimulates Guanylate Cyclase Pathway antibodies	Nitric Oxide Stimulates Guanylate Cyclase Pathway Diagram

Diseases associated with anti-PRKG2 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>7 publications with PRKG2 and Neoplasms
Bone Diseases Antibodies	>7 publications with PRKG2 and Bone Diseases
Growth Disorders Antibodies	>6 publications with PRKG2 and Growth Disorders
Congenital Abnormalities Antibodies	>3 publications with PRKG2 and Congenital Abnormalities
Aneuploidy Antibodies	>3 publications with PRKG2 and Aneuploidy
Abnormalities, Multiple Antibodies	>3 publications with PRKG2 and Abnormalities, Multiple
Hypertrophy Antibodies	>2 publications with PRKG2 and Hypertrophy
Cardiovascular Diseases Antibodies	>1 publications with PRKG2 and Cardiovascular Diseases
Atherosclerosis Antibodies	>1 publications with PRKG2 and Atherosclerosis
Liver Neoplasms Antibodies	>1 publications with PRKG2 and Liver Neoplasms

Organs/Tissues associated with anti-PRKG2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>16 publications with PRKG2 and Brain
Muscle Antibodies	>4 publications with PRKG2 and Muscle
Skin Antibodies	>1 publications with PRKG2 and Skin
Prostate Antibodies	>1 publications with PRKG2 and Prostate
Testis Antibodies	>1 publications with PRKG2 and Testis