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PRL Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6494634

MBS6494634 is an antibody targeting PRL. Also known as PRL (S163) (Prolactin) (APC). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PRL, Polyclonal Antibody
Full Product Name
PRL (S163) (Prolactin) (APC)
Product Gene Name
anti-PRL antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Immunoaffinity chromatography.
Specificity
Recognizes human PRL.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
23 kDa (200 aa), confirmed by MALDI-TOF.
OMIM
176760
3D Structure
ModBase 3D Structure for P01236
Immunogen
Synthetic peptide selected from the S163 region of human PRL (KLH).
Conjugate
APC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-PRL antibody

Antibodies; Hormones; Steroids
Applications Tested/Suitable for anti-PRL antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-PRL antibody
IHC: 1:50-1:100
FLISA: 1:1,000
WB: 1:100-1:500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-PRL antibody

Western blot analysis of PRL (arrow) using rabbit polyclonal Phospho-PRL-S163.ctrl. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PRL gene (Lane 2).
Rabbit Anti-PRL Polyclonal Antibody – Cat# MBS6494634

Immunohistochemistry (IHC) of anti-PRL antibody

Formalin-fixed and paraffin-embedded human breast carcinoma with Phospho-PRL-pS163 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-PRL Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6494634

Immunofluorescence (IF) of anti-PRL antibody

Confocal immunofluorescent analysis of PRL Antibody (S163) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-PRL Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS6494634

Product References and Citations for anti-PRL antibody

1. Liu, M.L., Int J Artif Organs 31(4), 303-308 (2008). 2. Carver, K.C., Mol. Cancer Res. 6(4), 634-643 (2008). 3. Swaminathan, G., J. Endocrinol. 196(2), R1-R7 (2008).

Other Notes

Small volumes of anti-PRL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PRL. It may not necessarily be applicable to this product.

NCBI GI #
4506105
NCBI GeneID
5617
NCBI Accession #
NP_000939
UniProt Primary Accession #
P01236
UniProt Secondary Accession #
Q15199; Q92996
UniProt Related Accession #
P01236
GenBank Nucleotide #
NM_000948.5
NCBI Official Full Name
prolactin
NCBI Official Synonym Full Names
prolactin
NCBI Official Symbol
PRL
NCBI Official Synonym Symbols
GHA1
UniProt Protein Name
Prolactin
Protein Family
Prolactin
UniProt Gene Name
PRL
UniProt Synonym Gene Names
PRL
UniProt Entry Name
PRL_HUMAN
NCBI Protein Information
prolactin

NCBI Summary for PRL

This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
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UniProt Comments for PRL

prolactin: Prolactin acts primarily on the mammary gland by promoting lactation. Belongs to the somatotropin/prolactin family.

Protein type: Secreted; Cytokine; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: extracellular region

Molecular Function: protein binding; prolactin receptor binding; hormone activity

Biological Process: lactation; cell proliferation; cell surface receptor linked signal transduction; regulation of multicellular organism growth; positive regulation of JAK-STAT cascade; female pregnancy
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Research Articles on PRL

1. GABA alpha2 and/or alpha3 receptor subtypes are involved in GABAergic modulation of prolactin secretion.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PRL antibody

 Reference Product  PubMed Publications
 PRLR antibody  >298 publications with PRL and PRLR

Pathways associated with anti-PRL antibody

 Products by Pathway  Pathway Diagram
 Amyloid Fiber Formation Pathway antibodies  Amyloid Fiber Formation Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 EV Release From Cardiac Cells And Their Functional Effects Pathway antibodies  EV Release From Cardiac Cells And Their Functional Effects Pathway Diagram
 ErbB4 Signaling Events Pathway antibodies  ErbB4 Signaling Events Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Growth Hormone Receptor Signaling Pathway antibodies  Growth Hormone Receptor Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with anti-PRL antibody

 Disease Name  Pubmed Publications
 Pituitary Neoplasms Antibodies  >1963 publications with PRL and Pituitary Neoplasms
 Hyperprolactinemia Antibodies  >1466 publications with PRL and Hyperprolactinemia
 Adenoma Antibodies  >1437 publications with PRL and Adenoma
 Prolactinoma Antibodies  >640 publications with PRL and Prolactinoma
 Mental Disorders Antibodies  >579 publications with PRL and Mental Disorders
 Amenorrhea Antibodies  >421 publications with PRL and Amenorrhea
 Galactorrhea Antibodies  >311 publications with PRL and Galactorrhea
 Growth Hormone-Secreting Pituitary Adenoma Antibodies  >251 publications with PRL and Growth Hormone-Secreting Pituitary Adenoma
 Hypogonadism Antibodies  >199 publications with PRL and Hypogonadism
 Puerperal Disorders Antibodies  >192 publications with PRL and Puerperal Disorders

Organs/Tissues associated with anti-PRL antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >482 publications with PRL and Testis
 Uncharacterized Tissue Antibodies  >1 publications with PRL and Uncharacterized Tissue
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