Rabbit Anti-PRMT8 Polyclonal Antibody – Cat# MBS6010980

Western Blot analysis of PRMT8 expression in transfected 293T cell line by PRMT8 polyclonal antibody. Lane 1: PRMT8 transfected lysate (45.3kD). Lane 2: Non-transfected lysate.

PRMT8 Antibody – Rabbit Polyclonal

Name: PRMT8 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6010980
Price: 970 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6010980

Protein arginine methylation plays a role in signal transduction, RNA processing, transcriptional regulation, and DNA repair. PRMT8, a protein arginine N-methyltransferase most closely related to PRMT1, methylates the guanidino nitrogens of arginyl residues… More details

$970 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PRMT8, Polyclonal Antibody

Full Product Name

PRMT8 (Protein Arginine N-methyltransferase 8, Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-like Protein 4, HRMT1L3, HRMT1L4)

Product Gene Name

anti-PRMT8 antibody

Product Synonym Names

Anti -PRMT8 (Protein Arginine N-methyltransferase 8, Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-like Protein 4, HRMT1L3, HRMT1L4)

Immunogen Sequence

MGMKHSSRCL LLRRKMAENA AESTEVNSPP SQPPQPVVPA KPVQCVHHVS TQPSCPGRGK MSKLLNPEEM TSRDYYFDSY AHFGIHEEML KDEVRTLTYR NSMYHNKHVF KDKVVLDVGS GTGILSMFAA KAGAKKVFGI ECSSISDYSE KIIKANHLDN IITIFKGKVE EVELPVEKVD IIISEWMGYC LFYESMLNTV IFARDKWLKP GGLMFPDRAA LYVVAIEDRQ YKDFKIHWWE NVYGFDMTCI RDVAMKEPLV DIVDPKQVVT NACLIKEVDI YTVKTEELSF TSAFCLQIQR NDYVHALVTY FNIEFTKCHK KMGFSTAPDA PYTHWKQTVF YLEDYLTVRR GEEIYGTISM KPNAKNVRDL DFTVDLDFKG QLCETSVSND YKMR

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human PRMT8.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

45,291 Da

Chromosome Location

Chromosome: 12; NC_000012.11 (3490515..3703139). Location: 12p13.3

OMIM

610086

3D Structure

ModBase 3D Structure for Q9NR22

Immunogen

Full length human PRMT8, aa1-394 (NP_062828.3).

Product Categories/Family for anti-PRMT8 antibody

Antibodies; Abs to Enzymes; Methyltransferase

Applications Tested/Suitable for anti-PRMT8 antibody

Western Blot (WB)

Application Notes for anti-PRMT8 antibody

Suitable for use in Western Blot.

Other Notes

Small volumes of anti-PRMT8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRMT8 purchase

MBS6010980 is an antibody targeting PRMT8. Also known as PRMT8 (Protein Arginine N-methyltransferase 8, Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-like Protein 4, HRMT1L3, HRMT1L4). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PRMT8. It may not necessarily be applicable to this product.

NCBI GI #

74099699

NCBI GeneID

56341

NCBI Accession #

NP_062828.3

UniProt Primary Accession #

Q9NR22

UniProt Secondary Accession #

Q8TBJ8; B2RDP0

UniProt Related Accession #

Q9NR22

GenBank Nucleotide #

NM_019854.4

NCBI Official Full Name

protein arginine N-methyltransferase 8 isoform 1

NCBI Official Synonym Full Names

protein arginine methyltransferase 8

NCBI Official Symbol

PRMT8

NCBI Official Synonym Symbols

HRMT1L3; HRMT1L4

UniProt Protein Name

Protein arginine N-methyltransferase 8

UniProt Synonym Protein Names

Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4

Protein Family

Protein arginine N-methyltransferase

UniProt Gene Name

PRMT8

UniProt Synonym Gene Names

HRMT1L3; HRMT1L4

UniProt Entry Name

ANM8_HUMAN

NCBI Protein Information

protein arginine N-methyltransferase 8; HMT1 hnRNP methyltransferase-like 3; protein arginine N-methyltransferase 4; heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4

NCBI Summary for PRMT8

Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]

UniProt Comments for PRMT8

PRMT8: Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS. Belongs to the protein arginine N-methyltransferase family. PRMT8 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.1.1.-; Methyltransferase; Methyltransferase, protein arginine

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: plasma membrane; nucleus; cytosol

Molecular Function: protein-arginine omega-N monomethyltransferase activity; identical protein binding; protein-arginine omega-N asymmetric methyltransferase activity; protein binding; protein homodimerization activity; protein heterodimerization activity; S-adenosylmethionine-dependent methyltransferase activity; histone-arginine N-methyltransferase activity

Biological Process: histone methylation; peptidyl-arginine methylation; regulation of transcription, DNA-dependent; regulation of protein binding; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

Research Articles on PRMT8

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PRMT8 antibody

Reference Product	PubMed Publications
PRMT1 antibody	>11 publications with PRMT8 and PRMT1
PRMT5 antibody	>1 publications with PRMT8 and PRMT5
EWSR1 antibody	>1 publications with PRMT8 and EWSR1

Diseases associated with anti-PRMT8 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>2 publications with PRMT8 and Neoplasms
Virus Diseases Antibodies	>1 publications with PRMT8 and Virus Diseases
Cardiovascular Diseases Antibodies	>1 publications with PRMT8 and Cardiovascular Diseases

Organs/Tissues associated with anti-PRMT8 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>9 publications with PRMT8 and Brain
Kidney Antibodies	>1 publications with PRMT8 and Kidney