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PRSS3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647034

PRSS3 encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine… More details

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Product Overview

Online Datasheet in PDF
Product Name
PRSS3, Polyclonal Antibody
Full Product Name
PRSS3, NT (PRSS3, PRSS4, TRY3, TRY4, Trypsin-3, Brain trypsinogen, Mesotrypsinogen, Serine protease 3, Serine protease 4, Trypsin III, Trypsin IV)
Product Gene Name
anti-PRSS3 antibody
Product Synonym Names
Anti -PRSS3, NT (PRSS3, PRSS4, TRY3, TRY4, Trypsin-3, Brain trypsinogen, Mesotrypsinogen, Serine protease 3, Serine protease 4, Trypsin III, Trypsin IV)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
32,529 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (33750464..33799229). Location: 9p11.2
OMIM
613578
3D Structure
ModBase 3D Structure for P35030
Immunogen
PRSS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-48 amino acids from the N-terminal region of human PRSS3.

Product Categories/Family for anti-PRSS3 antibody

Antibodies; Abs to Enzymes; Protease (Proteinase; Peptidase)
Applications Tested/Suitable for anti-PRSS3 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-PRSS3 antibody
Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-PRSS3 antibody

PRSS3 Antibody (N-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the PRSS3 antibody detected the PRSS3 protein (arrow).
Rabbit Anti-PRSS3 Polyclonal Antibody – Cat# MBS647034

Immunohistochemistry (IHC) of anti-PRSS3 antibody

PRSS3 antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PRSS3 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-PRSS3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS647034

Flow Cytometry (FC/FACS) of anti-PRSS3 antibody

PRSS3 Antibody (N-term) flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-PRSS3 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS647034

Other Notes

Small volumes of anti-PRSS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRSS3 purchase

MBS647034 is an antibody targeting PRSS3. Also known as PRSS3, NT (PRSS3, PRSS4, TRY3, TRY4, Trypsin-3, Brain trypsinogen, Mesotrypsinogen, Serine protease 3, Serine protease 4, Trypsin III, Trypsin IV). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PRSS3. It may not necessarily be applicable to this product.

NCBI GI #
118763987
NCBI GeneID
5646
NCBI Accession #
AAI28226.1
UniProt Primary Accession #
P35030
UniProt Secondary Accession #
P15951; Q15665; Q5VXV0; Q9UQV3; A8CED1; A9Z1Y4; E7ES07
UniProt Related Accession #
P35030
NCBI Official Full Name
PRSS3 protein
NCBI Official Synonym Full Names
protease, serine, 3
NCBI Official Symbol
PRSS3
NCBI Official Synonym Symbols
T9; MTG; TRY3; TRY4; PRSS4
UniProt Protein Name
Trypsin-3
UniProt Synonym Protein Names
Brain trypsinogen; Mesotrypsinogen; Serine protease 3; Serine protease 4; Trypsin III; Trypsin IV
UniProt Gene Name
PRSS3
UniProt Synonym Gene Names
PRSS4; TRY3; TRY4
UniProt Entry Name
TRY3_HUMAN
NCBI Protein Information
trypsin-3; trypsin IV; mesotrypsin; trypsin III; trypsinogen 4; trypsinogen 5; trypsinogen IV; mesotrypsinogen; brain trypsinogen; pancreatic trypsinogen III; protease, serine, 4 (trypsin 4, brain)

NCBI Summary for PRSS3

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]
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UniProt Comments for PRSS3

Function: Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5. Ref.7 Ref.8

Catalytic activity: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactor: Binds 1 calcium ion per subunit.

Subcellular location: Secreted.

Tissue specificity: Expressed in pancreas and brain. Also expressed in Paneth cells, at the base of small intestinal crypts. Ref.7

Sequence similarities: Belongs to the peptidase S1 family.Contains 1 peptidase S1 domain.
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Research Articles on PRSS3

1. IFN regulatory factor 2 (Irf2) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PRSS3 antibody

 Reference Product  PubMed Publications
 SPINK1 antibody  >4 publications with PRSS3 and SPINK1
 APP antibody  >2 publications with PRSS3 and APP
 VEGFA antibody  >1 publications with PRSS3 and VEGFA

Pathways associated with anti-PRSS3 antibody

 Products by Pathway  Pathway Diagram
 Alpha-defensins Pathway antibodies  Alpha-defensins Pathway Diagram
 Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway antibodies  Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway Diagram
 Defensins Pathway antibodies  Defensins Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram

Diseases associated with anti-PRSS3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >15 publications with PRSS3 and Neoplasms
 Carcinoma Antibodies  >7 publications with PRSS3 and Carcinoma
 Neoplasm Metastasis Antibodies  >5 publications with PRSS3 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >5 publications with PRSS3 and Breast Neoplasms
 Inflammation Antibodies  >4 publications with PRSS3 and Inflammation
 Lung Neoplasms Antibodies  >4 publications with PRSS3 and Lung Neoplasms
 Gastrointestinal Diseases Antibodies  >3 publications with PRSS3 and Gastrointestinal Diseases
 Carcinoma, Squamous Cell Antibodies  >3 publications with PRSS3 and Carcinoma, Squamous Cell
 Respiratory Tract Diseases Antibodies  >3 publications with PRSS3 and Respiratory Tract Diseases
 Urologic Neoplasms Antibodies  >3 publications with PRSS3 and Urologic Neoplasms

Organs/Tissues associated with anti-PRSS3 antibody

 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >12 publications with PRSS3 and Pancreas
 Brain Antibodies  >10 publications with PRSS3 and Brain
 Prostate Antibodies  >3 publications with PRSS3 and Prostate
 Intestine Antibodies  >3 publications with PRSS3 and Intestine
 Eye Antibodies  >2 publications with PRSS3 and Eye
 Skin Antibodies  >1 publications with PRSS3 and Skin
 Liver Antibodies  >1 publications with PRSS3 and Liver
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