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CYTH2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649362

The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The… More details

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Product Overview

Online Datasheet in PDF
Product Name
PSCD2 (CYTH2), Polyclonal Antibody
Full Product Name
PSCD2 (CYTH2, ARNO, PSCD2, PSCD2L, Cytohesin-2, ARF Exchange Factor, ARF Nucleotide-binding Site Opener, PH, SEC7 and Coiled-coil Domain-containing Protein 2)
Product Gene Name
anti-CYTH2 antibody
Product Synonym Names
Anti -PSCD2 (CYTH2, ARNO, PSCD2, PSCD2L, Cytohesin-2, ARF Exchange Factor, ARF Nucleotide-binding Site Opener, PH, SEC7 and Coiled-coil Domain-containing Protein 2)
Immunogen Sequence
MEDGVYEPPD LTPEERMELE NIRRRKQELL VEIQRLREEL SEAMSEVEGL EANEGSKTLQ RNRKMAMGRK KFNMDPKKGI QFLVENELLQ NTPEEIARFL YKGEGLNKTA IGDYLGEREE LNLAVLHAFV DLHEFTDLNL VQALRQFLWS FRLPGEAQKI DRMMEAFAQR YCLCNPGVFQ STDTCYVLSF AVIMLNTSLH NPNVRDKPGL ERFVAMNRGI NEGGDLPEEL LRNLYDSIRN EPFKIPEDDG NDLTHTFFNP DREGWLLKLG GGRVKTWKRR WFILTDNCLY YFEYTTDKEP RGIIPLENLS IREVDDPRKP NCFELYIPNN KGQLIKACKT EADGRVVEGN HMVYRISAPT QEEKDEWIKS IQAAVSVDPF YEMLAARKKR ISVKKKQEQP
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid.
Purity/Purification
Serum
Serum
Specificity
Recognizes human CYTH2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
46,546 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (48972465..48985571). Location: 19q13.33
OMIM
602488
3D Structure
ModBase 3D Structure for Q99418
Immunogen
Full length human CYTH2, aa1-400 (NP_059431.1)

Product Categories/Family for anti-CYTH2 antibody

Antibodies; Abs to Binding Proteins
Applications Tested/Suitable for anti-CYTH2 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-CYTH2 antibody
Suitable for use in Western Blot and Immunoprecipitation.

Western Blot (WB) of anti-CYTH2 antibody

Western Blot analysis of CYTH2 expression in transfected 293T cell line by CYTH2 polyclonal antibody. Lane 1: CYTH2 transfected lysate (46.5kD). Lane 2: Non-transfected lysate
Rabbit Anti-CYTH2 Polyclonal Antibody – Cat# MBS649362

Immunoprecipitation (IP) of anti-CYTH2 antibody

Immunoprecipitation of CYTH2 transfected lysate using CYTH2 rabbit polyclonal antibody and Protein A Magnetic Bead and immunoblotted with CYTH2 mouse polyclonal antibody
Rabbit Anti-CYTH2 Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS649362

Other Notes

Small volumes of anti-CYTH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CYTH2 purchase

MBS649362 is an antibody targeting CYTH2. Also known as PSCD2 (CYTH2, ARNO, PSCD2, PSCD2L, Cytohesin-2, ARF Exchange Factor, ARF Nucleotide-binding Site Opener, PH, SEC7 and Coiled-coil Domain-containing Protein 2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CYTH2. It may not necessarily be applicable to this product.

NCBI GI #
119572736
NCBI GeneID
9266
NCBI Accession #
EAW52351.1
UniProt Primary Accession #
Q99418
UniProt Secondary Accession #
Q8IXY9; Q92958; A8K8P0
UniProt Related Accession #
Q99418
NCBI Official Full Name
pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2), isoform CRA_c
NCBI Official Synonym Full Names
cytohesin 2
NCBI Official Symbol
CYTH2
NCBI Official Synonym Symbols
ARNO; CTS18; PSCD2; SEC7L; PSCD2L; CTS18.1; Sec7p-L; Sec7p-like
UniProt Protein Name
Cytohesin-2
UniProt Synonym Protein Names
ARF exchange factor; ARF nucleotide-binding site opener; Protein ARNO; PH, SEC7 and coiled-coil domain-containing protein 2
Protein Family
Cytohesin
UniProt Gene Name
CYTH2
UniProt Synonym Gene Names
ARNO; PSCD2; PSCD2L; Protein ARNO
UniProt Entry Name
CYH2_HUMAN
NCBI Protein Information
cytohesin-2; ARF exchange factor; ARF nucleotide-binding site opener; PH, SEC7 and coiled-coil domain-containing protein 2; pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2); pleckstrin homology, Sec7 and coiled/coil domains 2 (cytohesin-2)

UniProt Comments for CYTH2

Function: Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. Ref.6

Subunit structure: Heteromer. Composed of GRASP, CYTH2 and at least one GRM1

By similarity. Interacts with ARRB1. Interacts with ARL4D; the interaction is direct. Ref.5 Ref.6

Subcellular location: Cell membrane. Cytoplasm. Note: Both isoform 1 and isoform 2 are recruited to the cell membrane through its association with ARL4A, ARL4C and ARL4D. Requires also interaction with phosphoinositides for targeting to plasma membrane. Ref.6

Tissue specificity: Ubiquitous.

Domain: The PH domain is necessary and sufficient for plasma membrane relocalization.

Sequence similarities: Contains 1 PH domain.Contains 1 SEC7 domain.
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Research Articles on CYTH2

1. Arf6/ ARNO signaling mediates phospholipase-D, ERK1/2 and cofilin activation in pancreatic beta-cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CYTH2 antibody

 Reference Product  PubMed Publications
 ARF6 antibody  >3 publications with CYTH2 and ARF6
 ARF1 antibody  >1 publications with CYTH2 and ARF1

Pathways associated with anti-CYTH2 antibody

 Products by Pathway  Pathway Diagram
 Arf1 Pathway antibodies  Arf1 Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram

Diseases associated with anti-CYTH2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with CYTH2 and Inflammation

Organs/Tissues associated with anti-CYTH2 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >1 publications with CYTH2 and Muscle
 Vascular Antibodies  >1 publications with CYTH2 and Vascular
 Blood Antibodies  >1 publications with CYTH2 and Blood
 Embryonic Tissue Antibodies  >1 publications with CYTH2 and Embryonic Tissue
 Uterus Antibodies  >1 publications with CYTH2 and Uterus
 Placenta Antibodies  >1 publications with CYTH2 and Placenta
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