Rabbit Anti-PSTPIP1 Polyclonal Antibody – Cat# MBS6338401

PSTPIP1 Antibody – Rabbit Polyclonal

Name: PSTPIP1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6338401
Price: 1025 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6338401

Proline-serine-threonine Phosphatase-interacting Protein 1 (PSTPIP1) binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. PSTPIP1 appears to be a scaffold protein and a… More details

$1025 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PSTPIP1, Polyclonal Antibody

Full Product Name

PSTPIP1, NT (PSTPIP1, CD2BP1, Proline-serine-threonine phosphatase-interacting protein 1, CD2-binding protein 1, H-PIP) (MaxLight 750)

Product Gene Name

anti-PSTPIP1 antibody

Product Synonym Names

PSTPIP1; CD2BP1; Proline-serine-threonine phosphatase-interacting protein 1; CD2-binding protein 1; H-PIP

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

Purity/Purification

Purified by Protein A and Peptide Affinity Chromatography.

Specificity

Recognizes human PSTPIP1.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

45,354 Da

OMIM

phenotype 606347

3D Structure

ModBase 3D Structure for O43586

Immunogen

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 89-118 in the N-terminal region of human PSTPIP1. Species sequence homology: mouse

Conjugate

MaxLight750

Note

Preservative Free

Product Categories/Family for anti-PSTPIP1 antibody

Antibodies; CD Markers

Applications Tested/Suitable for anti-PSTPIP1 antibody

Western Blot (WB), Flow Cytometry (FC/FACS), FLISA

Application Notes for anti-PSTPIP1 antibody

Applications are based on unconjugated antibody.

Product References and Citations for anti-PSTPIP1 antibody

1. Andre, M.F., et al., Dig. Dis. Sci. 55(6): 1681-1688 (2010). 2. Rose, J., et al., Mol. Med. 16(7-8): 247-253 (2010). 3. Hong, J.B., et al., J. Am. Acad. Dermatol. 61(3): 533-535 (2009). 4. Voss, M., et al., BMC Immunol. 10: 53 (2009). 5. Waite, A.L., et al., PLoS ONE 4(7): E6147 (2009).

Other Notes

Small volumes of anti-PSTPIP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PSTPIP1 purchase

MBS6338401 is an antibody targeting PSTPIP1. Also known as PSTPIP1, NT (PSTPIP1, CD2BP1, Proline-serine-threonine phosphatase-interacting protein 1, CD2-binding protein 1, H-PIP) (MaxLight 750). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PSTPIP1. It may not necessarily be applicable to this product.

NCBI GI #

20149528

NCBI GeneID

9051

NCBI Accession #

NP_003969.2

UniProt Primary Accession #

O43586

UniProt Secondary Accession #

O43585; O95657; B5BU74; B5BUK4

UniProt Related Accession #

O43586

GenBank Nucleotide #

NM_003978.3

NCBI Official Full Name

proline-serine-threonine phosphatase-interacting protein 1

NCBI Official Synonym Full Names

proline-serine-threonine phosphatase interacting protein 1

NCBI Official Symbol

PSTPIP1

NCBI Official Synonym Symbols

H-PIP; PAPAS; CD2BP1; PSTPIP; CD2BP1L; CD2BP1S

UniProt Protein Name

Proline-serine-threonine phosphatase-interacting protein 1

UniProt Synonym Protein Names

CD2-binding protein 1; H-PIP

Protein Family

Proline-serine-threonine phosphatase-interacting protein

UniProt Gene Name

PSTPIP1

UniProt Synonym Gene Names

CD2BP1; PEST phosphatase-interacting protein 1

UniProt Entry Name

PPIP1_HUMAN

NCBI Protein Information

proline-serine-threonine phosphatase-interacting protein 1; CD2 antigen-binding protein 1; CD2 cytoplasmic tail-binding protein; CD2-binding protein 1; PEST phosphatase-interacting protein 1

NCBI Summary for PSTPIP1

The protein encoded by this gene binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome. [provided by RefSeq, Jul 2008]

UniProt Comments for PSTPIP1

PSTPIP1: an SH3-domain containing protein that may play a role in vesicle formation and transport. Interacts with PTP-PEST to inhibit WASp-driven actin polymerization and synapse formation.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 15q24.3

Cellular Component: membrane; lamellipodium; perinuclear region of cytoplasm; contractile ring; stress fiber; uropod; cytosol; cleavage furrow

Molecular Function: protein binding; actin binding; protein phosphatase binding

Biological Process: innate immune response; endocytosis; inflammatory response; signal transduction; cell adhesion

Disease: Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne

Research Articles on PSTPIP1

1. we have shown that PSTPIP1 regulates T-cell activation upon CD3 and CD28 stimulation, independently of CD2 costimulation. PSTPIP1 acts downstream of proximal TCR signaling, inhibiting several transcription factors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PSTPIP1 antibody

Reference Product	PubMed Publications
MEFV antibody	>11 publications with PSTPIP1 and MEFV
PTPN12 antibody	>7 publications with PSTPIP1 and PTPN12
CD2 antibody	>6 publications with PSTPIP1 and CD2
PYCARD antibody	>2 publications with PSTPIP1 and PYCARD
FASLG antibody	>1 publications with PSTPIP1 and FASLG
ABL1 antibody	>1 publications with PSTPIP1 and ABL1

Pathways associated with anti-PSTPIP1 antibody

Products by Pathway	Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Inflammasomes Pathway antibodies	Inflammasomes Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
NOD-like Receptor Signaling Pathway antibodies	NOD-like Receptor Signaling Pathway Diagram
NOD-like Receptor Signaling Pathway antibodies	NOD-like Receptor Signaling Pathway Diagram
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways antibodies	Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways Diagram
TCR Signaling Pathway antibodies	TCR Signaling Pathway Diagram
The NLRP3 Inflammasome Pathway antibodies	The NLRP3 Inflammasome Pathway Diagram

Diseases associated with anti-PSTPIP1 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>19 publications with PSTPIP1 and Inflammation
Necrosis Antibodies	>15 publications with PSTPIP1 and Necrosis
Pyogenic arthritis, pyoderma gangrenosum, and acne Antibodies	>10 publications with PSTPIP1 and Pyogenic arthritis, pyoderma gangrenosum, and acne
Cardiovascular Diseases Antibodies	>2 publications with PSTPIP1 and Cardiovascular Diseases

Organs/Tissues associated with anti-PSTPIP1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>18 publications with PSTPIP1 and Blood
Skin Antibodies	>15 publications with PSTPIP1 and Skin
Bone Antibodies	>6 publications with PSTPIP1 and Bone
Eye Antibodies	>1 publications with PSTPIP1 and Eye
Bone Marrow Antibodies	>1 publications with PSTPIP1 and Bone Marrow
Spleen Antibodies	>1 publications with PSTPIP1 and Spleen