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PVRL4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9447106

This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a… More details

$435 / 0.1 mL (Biotin) +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PVRL4, Polyclonal Antibody
Full Product Name
PVRL4 Conjugated Antibody
Product Gene Name
anti-PVRL4 antibody
Product Synonym Names
LNIR; PRR4; EDSS1; nectin-4
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
Specificity
The antibody detects endogenous levels of total PVRL4 protein.
Preparation and Storage
Store at 4 degree C for 6 months.
Molecular Weight
24,341 Da
OMIM
609607
3D Structure
ModBase 3D Structure for Q96NY8
Immunogen
Fusion protein corresponding to residues near the C terminal of human poliovirus receptor-related 4
Conjugation
Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
Excitation Emission
AF350: 346nm/442nm
Applications Tested/Suitable for anti-PVRL4 antibody
Most Applications
Application Notes for anti-PVRL4 antibody
Suggested Dilution:
AF350 conjugated: most applications: 1:50-1:250
AF405 conjugated: most applications: 1:50-1:250
AF488 conjugated: most applications: 1:50-1:250
AF555 conjugated: most applications: 1:50-1:250
AF594 conjugated: most applications: 1:50-1:250
AF647 conjugated: most applications: 1:50-1:250
AF680 conjugated: most applications: 1:50-1:250
AF750 conjugated: most applications: 1:50-1:250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000

Other Notes

Small volumes of anti-PVRL4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PVRL4 purchase

MBS9447106 is an antibody targeting PVRL4. Also known as PVRL4 Conjugated Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PVRL4. It may not necessarily be applicable to this product.

NCBI GI #
14714573
NCBI GeneID
81607
NCBI Accession #
BC010423
UniProt Primary Accession #
Q96NY8
UniProt Secondary Accession #
Q96NY8
UniProt Related Accession #
Q96NY8
NCBI Official Full Name
Homo sapiens poliovirus receptor-related 4, mRNA
NCBI Official Synonym Full Names
nectin cell adhesion molecule 4
NCBI Official Symbol
NECTIN4
NCBI Official Synonym Symbols
LNIR; PRR4; EDSS1; PVRL4; nectin-4
UniProt Protein Name
Poliovirus receptor-related protein 4
UniProt Synonym Protein Names
Ig superfamily receptor LNIR; Nectin-4
UniProt Gene Name
PVRL4
UniProt Synonym Gene Names
LNIR; PRR4
UniProt Entry Name
PVRL4_HUMAN
NCBI Protein Information
nectin-4

UniProt Comments for PVRL4

nectin 4: Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells. Defects in PVRL4 are the cause of ectodermal dysplasia- syndactyly syndrome type 1 (EDSS1). EDSS1 is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSS1 is characterized by the association of hair and teeth abnormalities with cutaneous syndactyly of the hands and/or feet. Hair morphologic abnormalities include twists at irregular intervals (pilli torti) and swelling along the shafts, particularly associated with areas of breakage. Dental findings consist of abnormally widely spaced teeth, with peg-shaped and conical crowns. Patients have normal sweating. Belongs to the nectin family.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: adherens junction; plasma membrane; integral to membrane

Molecular Function: protein binding

Biological Process: intercellular junction assembly and maintenance; viral reproduction; cell adhesion

Disease: Ectodermal Dysplasia-syndactyly Syndrome 1
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Research Articles on PVRL4

1. Nectin-4 is critical for gallbladder cancer cell progression via PI3K/AKT pathway activation of Rac1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PVRL4 antibody

 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
 Nectin/Necl Trans Heterodimerization Pathway antibodies  Nectin/Necl Trans Heterodimerization Pathway Diagram

Diseases associated with anti-PVRL4 antibody

 Disease Name  Pubmed Publications
 ECTODERMAL DYSPLASIA-SYNDACTYLY SYNDROME 1 Antibodies  >4 publications with PVRL4 and ECTODERMAL DYSPLASIA-SYNDACTYLY SYNDROME 1
 Neoplasms Antibodies  >3 publications with PVRL4 and Neoplasms
 Fever Antibodies  >1 publications with PVRL4 and Fever
 Necrosis Antibodies  >1 publications with PVRL4 and Necrosis
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