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QPRT Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6339437

This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been… More details

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Product Overview

Online Datasheet in PDF
Product Name
QPRT, Polyclonal Antibody
Full Product Name
QPRT, CT (QPRT, Nicotinate-nucleotide pyrophosphorylase [carboxylating], Quinolinate phosphoribosyltransferase [decarboxylating]) (AP)
Product Gene Name
anti-QPRT antibody
Product Synonym Names
QPRT; Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Quinolinate phosphoribosyltransferase [decarboxylating]
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
OMIM
606248
3D Structure
ModBase 3D Structure for Q15274
Immunogen
QPRT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the C-terminal region of human QPRT.
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-QPRT antibody

Antibodies; Enzymes
Applications Tested/Suitable for anti-QPRT antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-QPRT antibody
IHC: 1:10-50
ELISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-QPRT antibody

QPRT Antibody (C-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the QPRT antibody detected the QPRT protein (arrow).
Rabbit Anti-QPRT Polyclonal Antibody – Cat# MBS6339437

Immunohistochemistry (IHC) of anti-QPRT antibody

QPRT Antibody (C-term) (AP14383b)immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of QPRT Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-QPRT Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6339437

Product References and Citations for anti-QPRT antibody

Hinsch, N., et al. BMC Cancer 9, 93 (2009): Liu, H., et al. J. Mol. Biol. 373(3):755-763(2007). Magni, G., et al. Cell. Mol. Life Sci. 61(1):19-34(2004). Fukuoka, S., et al. Adv. Exp. Med. Biol. 467, 611-614 (1999): Fukuoka, S.I., et al. Biochim. Biophys. Acta 1395(2):192-201(1998).

Other Notes

Small volumes of anti-QPRT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for QPRT purchase

MBS6339437 is an antibody targeting QPRT. Also known as QPRT, CT (QPRT, Nicotinate-nucleotide pyrophosphorylase [carboxylating], Quinolinate phosphoribosyltransferase [decarboxylating]) (AP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for QPRT. It may not necessarily be applicable to this product.

NCBI GI #
45269149
NCBI GeneID
23475
NCBI Accession #
NP_055113.2
UniProt Primary Accession #
Q15274
UniProt Secondary Accession #
Q53XW7; Q96G22; Q9BSG6
UniProt Related Accession #
Q15274
GenBank Nucleotide #
NM_014298.3
NCBI Official Full Name
nicotinate-nucleotide pyrophosphorylase
NCBI Official Synonym Full Names
quinolinate phosphoribosyltransferase
NCBI Official Symbol
QPRT
NCBI Official Synonym Symbols
QPRTase; HEL-S-90n
UniProt Protein Name
Nicotinate-nucleotide pyrophosphorylase [carboxylating]
UniProt Synonym Protein Names
Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTase
Protein Family
Nicotinate-nucleotide pyrophosphorylase
UniProt Gene Name
QPRT
UniProt Synonym Gene Names
QAPRTase; QPRTase
UniProt Entry Name
NADC_HUMAN
NCBI Protein Information
nicotinate-nucleotide pyrophosphorylase [carboxylating]; nicotinate-nucleotide pyrophosphorylase [carboxylating]; QAPRTase; epididymis secretory sperm binding protein Li 90n; nicotinate-nucleotide pyrophosphorylase (carboxylating)

UniProt Comments for QPRT

QPRT: Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.

Protein type: Transferase; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.4.2.19

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytoplasm; cytosol

Molecular Function: protein homodimerization activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity

Biological Process: NAD biosynthetic process; vitamin metabolic process; NAD metabolic process; water-soluble vitamin metabolic process; protein oligomerization
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Research Articles on QPRT

1. Report of the crystal structure of human QPRT bound to its inhibitor phthalic acid (PHT) and kinetic analysis of PHT inhibition of human QPRT.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-QPRT antibody

 Products by Pathway  Pathway Diagram
 Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective BTD Causes Biotidinase Deficiency Pathway antibodies  Defective BTD Causes Biotidinase Deficiency Pathway Diagram
 Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies  Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
 Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies  Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram
 Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies  Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
 Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway antibodies  Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway Diagram
 Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway antibodies  Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway Diagram
 Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway antibodies  Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway Diagram
 Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway antibodies  Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway Diagram

Diseases associated with anti-QPRT antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with QPRT and Nervous System Diseases
 Cognition Disorders Antibodies  >2 publications with QPRT and Cognition Disorders
 Nerve Degeneration Antibodies  >1 publications with QPRT and Nerve Degeneration
 Carcinoma Antibodies  >1 publications with QPRT and Carcinoma
 Kidney Diseases Antibodies  >1 publications with QPRT and Kidney Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with QPRT and Cell Transformation, Neoplastic
 Inflammation Antibodies  >1 publications with QPRT and Inflammation

Organs/Tissues associated with anti-QPRT antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with QPRT and Brain
 Liver Antibodies  >9 publications with QPRT and Liver
 Blood Antibodies  >4 publications with QPRT and Blood
 Kidney Antibodies  >4 publications with QPRT and Kidney
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