RAB27A Antibody – Rabbit Polyclonal

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

RAB27A: Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Defects in RAB27A are a cause of Griscelli syndrome type 2 (GS2). Griscelli syndrome is a rare autosomal recessive disorder that results in pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes. GS2 patients also develop an uncontrolled T-lymphocyte and macrophage activation syndrome, known as hemophagocytic syndrome, leading to death in the absence of bone marrow transplantation. Neurological impairment is present in some patients, likely as a result of hemophagocytic syndrome. Belongs to the small GTPase superfamily. Rab family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein, monomeric; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 15q15-q21.1

Cellular Component: apical plasma membrane; cytosol; dendrite; Golgi apparatus; late endosome; lysosome; melanosome; photoreceptor outer segment; secretory granule; secretory granule membrane

Molecular Function: GDP binding; GTP binding; GTPase activity; myosin V binding; protein binding; protein domain specific binding

Biological Process: antigen processing and presentation; blood coagulation; cytotoxic T cell degranulation; exocytosis; melanocyte differentiation; melanosome localization; melanosome transport; metabolic process; natural killer cell degranulation; nucleocytoplasmic transport; positive regulation of exocytosis; positive regulation of phagocytosis; protein targeting; small GTPase mediated signal transduction; synaptic vesicle transport

Disease: Griscelli Syndrome, Type 2