Rabbit Anti-RAB7B Polyclonal Antibody – Cat# MBS6002676

RAB7B Antibody (C-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the RAB7B antibody detected the RAB7B protein (arrow).

RAB7B Antibody – Rabbit Polyclonal

Name: RAB7B Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6002676
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6002676

MBS6002676 is an antibody targeting RAB7B. Also known as RAB7B, CT (RAB7B, Ras-related protein Rab-7b). Reactive in Human. Host: Rabbit. Protein transport. Probably involved in vesicular traffic (By similarity). More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RAB7B, Polyclonal Antibody

Full Product Name

RAB7B, CT (RAB7B, Ras-related protein Rab-7b)

Product Gene Name

anti-RAB7B antibody

Product Synonym Names

Anti -RAB7B, CT (RAB7B, Ras-related protein Rab-7b)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

22,511 Da

Chromosome Location

1q32

3D Structure

ModBase 3D Structure for Q96AH8

Immunogen

RAB7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-198 amino acids from the C-terminal region of human RAB7B.

Product Categories/Family for anti-RAB7B antibody

Antibodies; Abs to GTPase; Rab; Ras; Rho Proteins

Applications Tested/Suitable for anti-RAB7B antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-RAB7B antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-RAB7B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RAB7B. It may not necessarily be applicable to this product.

NCBI GI #

256985160

NCBI GeneID

338382

NCBI Accession #

NP_001157994.1

UniProt Primary Accession #

Q96AH8

UniProt Related Accession #

Q96AH8

GenBank Nucleotide #

NM_001164522.1

NCBI Official Full Name

ras-related protein Rab-7b

NCBI Official Synonym Full Names

RAB7B, member RAS oncogene family

NCBI Official Symbol

RAB7B

NCBI Official Synonym Symbols

RAB7

UniProt Protein Name

Ras-related protein Rab-7b

Protein Family

Ras-related protein

UniProt Gene Name

RAB7B

UniProt Entry Name

RAB7B_HUMAN

NCBI Protein Information

ras-related protein Rab-7b; Ras-related protein Rab-7

UniProt Comments for RAB7B

RAB7B: Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway. Belongs to the small GTPase superfamily. Rab family.

Protein type: G protein, monomeric; G protein; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: Golgi apparatus; phagocytic vesicle membrane; lysosome; late endosome; trans-Golgi network; phagocytic vesicle

Molecular Function: GTP binding

Biological Process: negative regulation of toll-like receptor 9 signaling pathway; protein transport; small GTPase mediated signal transduction; negative regulation of toll-like receptor 4 signaling pathway; positive regulation of interleukin-6 production; positive regulation of megakaryocyte differentiation; activation of NF-kappaB transcription factor

Research Articles on RAB7B

1. Rab9a and Rab7b are mediators of the transit of the L2 capsid protien and the pseudogenome of human papillomavirus 16 from the late endosome to the golgi complex.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-RAB7B antibody

Products by Pathway	Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Phagosome Pathway antibodies	Phagosome Pathway Diagram
Phagosome Pathway antibodies	Phagosome Pathway Diagram
Salmonella Infection Pathway antibodies	Salmonella Infection Pathway Diagram
Salmonella Infection Pathway antibodies	Salmonella Infection Pathway Diagram

Diseases associated with anti-RAB7B antibody

Disease Name	Pubmed Publications
Autoimmune Diseases Antibodies	>2 publications with RAB7B and Autoimmune Diseases
Paralysis Antibodies	>1 publications with RAB7B and Paralysis
Neoplasms Antibodies	>1 publications with RAB7B and Neoplasms
Necrosis Antibodies	>1 publications with RAB7B and Necrosis

Organs/Tissues associated with anti-RAB7B antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>4 publications with RAB7B and Brain
Lung Antibodies	>3 publications with RAB7B and Lung
Heart Antibodies	>1 publications with RAB7B and Heart
Placenta Antibodies	>1 publications with RAB7B and Placenta