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RANBP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3901076

Ran-binding protein 1 (RanBP1) binds to the GTP-binding protein, Ran, when it is specifically complexed with GTP. RanBP1 binding to GTP-charged RAN increases the catalytic efficiency of GTP hydrolysis activated by RanGAP, the Ran specific GTPase-activating… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
RanBP1, Polyclonal Antibody
Full Product Name
Rabbit anti-RanBP1 Antibody, Affinity Purified
Product Gene Name
anti-RANBP1 antibody
Product Synonym Names
Ran-binding protein 1; testis secretory sperm-binding protein Li 221n; RanBP1; HTF9A; HpaII tiny fragments locus 9A; ran-specific GTPase-activating protein; Ran-specific GTPase-activating protein; RAN binding protein 1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Chromosome Location
chromosome: 22; Location:
OMIM
601180
3D Structure
ModBase 3D Structure for P43487
Immunogen
Between 151 and C-terminus
Conjugation
Unconjugated

Product Categories/Family for anti-RANBP1 antibody

Primary Antibodies
Applications Tested/Suitable for anti-RANBP1 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-RANBP1 antibody
WB: 1:1000-1:5000
IP: 6ug/mg lysate

Western Blot (WB) of anti-RANBP1 antibody

Detection of human RanBP1 by western blot. Samples: Whole cell lysate (50 ug) from HeLa and HEK293T cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-RanBP1 antibody MBS3901076 (lot MBS3901076-2) used for WB at 0.2 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
Rabbit Anti-RANBP1 Polyclonal Antibody – Cat# MBS3901076

Other Notes

Small volumes of anti-RANBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RANBP1 purchase

MBS3901076 is an antibody targeting RANBP1. Also known as Rabbit anti-RanBP1 Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RANBP1. It may not necessarily be applicable to this product.

NCBI GI #
4506407
NCBI GeneID
5902
NCBI Accession #
NP_002873.1
UniProt Primary Accession #
P43487
NCBI Official Full Name
ran-specific GTPase-activating protein [Homo sapiens]
NCBI Official Synonym Full Names
RAN binding protein 1
NCBI Official Symbol
RANBP1
NCBI Official Synonym Symbols
HTF9A; MGC88701; RANBP1
UniProt Protein Name
Ran-specific GTPase-activating protein
UniProt Synonym Protein Names
Ran-binding protein 1; RanBP1
Protein Family
Ran-specific GTPase-activating protein
UniProt Gene Name
RANBP1
UniProt Synonym Gene Names
RanBP1
UniProt Entry Name
RANG_HUMAN

UniProt Comments for RANBP1

RANBP1: a Ran-binding protein that functions in nuclear trafficking, mitosis, chromosomal segregation, and ciliogenesis. Controls both nuclear import and export. Contains a Ran binding domain and a C-terminal nuclear export signal. Following export from the nucleus, forms a complex with RanGTP and XPO1/cargo, leading to dissociation of cargo from XPO1. Stimulates RanGAP1 association with RanGTP, facilitating RanGTP hydrolysis to RanGDP. Stabilizes and regulates the formation of a RanGDP-importin/NLS receptor-RanBP1 complex during nuclear import. Controls RanGTP distribution along mitotic microtubules, which localizes critical factors, such as cyclin B1 and DLG7, to mitotic microtubles and regulates chromosome segregation. Knock down or overexpression experiments affect cellular ciliogenesis by regulating the local RanGTP concentation at the base of cilia.Belongs to the RANBP1 family.

Protein type: G protein regulator, misc.; Microtubule-binding; Cell cycle regulation

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: cytoplasm; nuclear envelope; nucleus

Molecular Function: GDP-dissociation inhibitor activity; Ran GTPase binding; GTPase activator activity

Biological Process: intracellular transport; viral reproduction; regulation of catalytic activity; signal transduction; positive regulation of GTPase activity
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RANBP1 antibody

 Reference Product  PubMed Publications
 RAN antibody  >115 publications with RANBP1 and RAN
 RCC1 antibody  >34 publications with RANBP1 and RCC1
 XPO1 antibody  >3 publications with RANBP1 and XPO1
 IPO5 antibody  >2 publications with RANBP1 and IPO5
 KPNB1 antibody  >1 publications with RANBP1 and KPNB1

Pathways associated with anti-RANBP1 antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 HIV Life Cycle Pathway antibodies  HIV Life Cycle Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Host Interactions Of HIV Factors Pathway antibodies  Host Interactions Of HIV Factors Pathway Diagram
 Interactions Of Rev With Host Cellular Proteins Pathway antibodies  Interactions Of Rev With Host Cellular Proteins Pathway Diagram
 Late Phase Of HIV Life Cycle Pathway antibodies  Late Phase Of HIV Life Cycle Pathway Diagram
 Rev-mediated Nuclear Export Of HIV-1 RNA Pathway antibodies  Rev-mediated Nuclear Export Of HIV-1 RNA Pathway Diagram

Diseases associated with anti-RANBP1 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >3 publications with RANBP1 and Carcinoma
 Lung Neoplasms Antibodies  >1 publications with RANBP1 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >1 publications with RANBP1 and Neoplasm Metastasis
 Infertility, Male Antibodies  >1 publications with RANBP1 and Infertility, Male
 Fatty Liver Antibodies  >1 publications with RANBP1 and Fatty Liver

Organs/Tissues associated with anti-RANBP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4 publications with RANBP1 and Liver
 Lung Antibodies  >4 publications with RANBP1 and Lung
 Kidney Antibodies  >3 publications with RANBP1 and Kidney
 Heart Antibodies  >3 publications with RANBP1 and Heart
 Blood Antibodies  >3 publications with RANBP1 and Blood
 Skin Antibodies  >2 publications with RANBP1 and Skin
 Brain Antibodies  >2 publications with RANBP1 and Brain
 Vascular Antibodies  >1 publications with RANBP1 and Vascular
 Eye Antibodies  >1 publications with RANBP1 and Eye
 Uncharacterized Tissue Antibodies  >1 publications with RANBP1 and Uncharacterized Tissue
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