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RANK Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6404622

MBS6404622 is an antibody targeting RANK. Also known as RANK (Osteoclast differentiation factor receptor) (AP). Reactive in Human. Host: Rabbit. More details

$825 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RANK, Polyclonal Antibody
Full Product Name
RANK (Osteoclast differentiation factor receptor) (AP)
Product Gene Name
anti-RANK antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Immunoaffinity chromatography.
Specificity
Recognizes human RANK. No crossreactivity with other proteins.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
64,552 Da
OMIM
174810
3D Structure
ModBase 3D Structure for Q9Y6Q6
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminal of human RANK.
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-RANK antibody

Antibodies; RANK
Applications Tested/Suitable for anti-RANK antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-RANK antibody
WB: 2.5ng/lane under non-reducing and reducing conditions.
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-RANK antibody

Western Blot using 145118 Lane 1: Recombinant Human RANK Protein 10ng Lane 2: Recombinant Human RANK Protein 5ng Lane 3: Recombinant Human RANK Protein 2.5ng
Rabbit Anti-RANK Polyclonal Antibody – Cat# MBS6404622

Immunohistochemistry (IHC) of anti-RANK antibody

Immunohistochemistry in paraffin Human Mammary Cancer Tissue using 145118.
Rabbit Anti-RANK Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6404622

Product References and Citations for anti-RANK antibody

1. Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ (1999). "Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families". Endocr. Rev. 20 (3): 345-57. 2. Wong BR, Josien R, Choi Y (1999). "TRANCE is a TNF family member that regulates dendritic cell and osteoclast function". J. Leukoc. Biol. 65 (6): 715-24. 3. Theill LE, Boyle WJ, Penninger JM (2002). "RANK-L and RANK: T cells, bone loss, and mammalian evolution". Annu. Rev. Immunol. 20: 795-823.

Other Notes

Small volumes of anti-RANK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RANK. It may not necessarily be applicable to this product.

NCBI GI #
401015111
NCBI GeneID
8792
NCBI Accession #
NP_001257878.1
UniProt Primary Accession #
Q9Y6Q6
UniProt Secondary Accession #
Q59EP9; I4EC36; I4EC38; I4EC39; I7JE63; N0GVH0
UniProt Related Accession #
Q9Y6Q6
GenBank Nucleotide #
NM_001270949.1
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 11A isoform 2
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily member 11a
NCBI Official Symbol
TNFRSF11A
NCBI Official Synonym Symbols
FEO; OFE; ODFR; OSTS; PDB2; RANK; CD265; OPTB7; TRANCER; LOH18CR1
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 11A
UniProt Synonym Protein Names
Osteoclast differentiation factor receptor; ODFR; Receptor activator of NF-KB; CD_antigen: CD265
Protein Family
Rabankyrin
UniProt Gene Name
TNFRSF11A
UniProt Synonym Gene Names
RANK; ODFR
UniProt Entry Name
TNR11_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 11A

UniProt Comments for RANK

TNFRSF11A: Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts (via cytoplasmic domain) with GAB2. Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q22.1

Cellular Component: external side of plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: cytokine binding; protein binding; receptor activity; transmembrane receptor activity; tumor necrosis factor receptor activity

Biological Process: activation of NF-kappaB transcription factor; adaptive immune response; cell-cell signaling; circadian thermoregulation; inflammatory response; osteoclast differentiation; positive regulation of cell proliferation; positive regulation of JNK activity; positive regulation of transcription factor activity; regulation of apoptosis; response to cytokine stimulus; response to lipopolysaccharide; signal transduction; tumor necrosis factor-mediated signaling pathway

Disease: Familial Expansile Osteolysis; Osteopetrosis, Autosomal Recessive 7; Paget Disease Of Bone
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RANK antibody

 Reference Product  PubMed Publications
 TNFSF11 antibody  >1513 publications with RANK and TNFSF11
 TRAF6 antibody  >65 publications with RANK and TRAF6
 FOS antibody  >49 publications with RANK and FOS
 SRC antibody  >38 publications with RANK and SRC
 TRAF2 antibody  >15 publications with RANK and TRAF2
 TRAF1 antibody  >8 publications with RANK and TRAF1
 TRAF5 antibody  >8 publications with RANK and TRAF5
 TRAF3 antibody  >6 publications with RANK and TRAF3
 PIGN antibody  >2 publications with RANK and PIGN

Pathways associated with anti-RANK antibody

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Osteoclast Signaling Pathway antibodies  Osteoclast Signaling Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram

Diseases associated with anti-RANK antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >893 publications with RANK and Necrosis
 Inflammation Antibodies  >154 publications with RANK and Inflammation
 Cardiovascular Diseases Antibodies  >112 publications with RANK and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >66 publications with RANK and Breast Neoplasms
 Osteitis Deformans Antibodies  >53 publications with RANK and Osteitis Deformans
 Neoplasm Metastasis Antibodies  >44 publications with RANK and Neoplasm Metastasis
 Osteosarcoma Antibodies  >33 publications with RANK and Osteosarcoma
 Kidney Diseases Antibodies  >24 publications with RANK and Kidney Diseases
 Neoplasms, Experimental Antibodies  >23 publications with RANK and Neoplasms, Experimental
 Heart Diseases Antibodies  >18 publications with RANK and Heart Diseases

Organs/Tissues associated with anti-RANK antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1408 publications with RANK and Bone
 Vascular Antibodies  >81 publications with RANK and Vascular
 Skin Antibodies  >24 publications with RANK and Skin
 Liver Antibodies  >22 publications with RANK and Liver
 Lung Antibodies  >22 publications with RANK and Lung
 Brain Antibodies  >21 publications with RANK and Brain
 Heart Antibodies  >20 publications with RANK and Heart
 Kidney Antibodies  >20 publications with RANK and Kidney
 Embryonic Tissue Antibodies  >19 publications with RANK and Embryonic Tissue
 Intestine Antibodies  >9 publications with RANK and Intestine
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