RBM4 Antibody – Rabbit Polyclonal

RBM4: RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of EIF2C2- containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cytoplasm; nuclear speck; nucleolus; nucleoplasm; nucleus; stress granule

Molecular Function: miRNA binding; mRNA 3'-UTR binding; mRNA binding; protein binding; RNA binding

Biological Process: entrainment of circadian clock by photoperiod; miRNA-mediated gene silencing, negative regulation of translation; negative regulation of translation; negative regulation of translation in response to stress; negative regulation of translational initiation; positive regulation of muscle cell differentiation; regulation of alternative nuclear mRNA splicing, via spliceosome; regulation of nucleocytoplasmic transport; response to arsenic; RNA processing; stress-activated MAPK cascade