Rabbit Anti-RCAN3 Polyclonal Antibody – Cat# MBS6341023

RCAN3 Antibody – Rabbit Polyclonal

Name: RCAN3 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6341023
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6341023

RCAN3 inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity). More details

$1060 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RCAN3, Polyclonal Antibody

Full Product Name

RCAN3, CT (RCAN3, DSCR1L2, Calcipressin-3, Down syndrome candidate region 1-like protein 2, Myocyte-enriched calcineurin-interacting protein 3, Regulator of calcineurin 3) (MaxLight 650)

Product Gene Name

anti-RCAN3 antibody

Product Synonym Names

RCAN3; DSCR1L2; Calcipressin-3; Down syndrome candidate region 1-like protein 2; Myocyte-enriched calcineurin-interacting protein 3; Regulator of calcineurin 3

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

27,492 Da

Chromosome Location

Chromosome: 1; NC_000001.10 (24829387..24862428). Location: 1p35.3-p33

OMIM

605860

3D Structure

ModBase 3D Structure for Q9UKA8

Immunogen

RCAN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 193-222 amino acids from the C-terminal region of human RCAN3.

Conjugate

MaxLight650

Note

Preservative Free

Product Categories/Family for anti-RCAN3 antibody

Antibodies; Disease Markers

Applications Tested/Suitable for anti-RCAN3 antibody

Immunohistochemistry (IHC), FLISA, Western Blot (WB)

Application Notes for anti-RCAN3 antibody

IHC: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-RCAN3 antibody

Sales, K.J., et al. Biochim. Biophys. Acta 1793(12):1917-1928(2009). Enjuanes, A., et al. Cancer Res. 68(24):10178-10186(2008). Facchin, F., et al. Gene 407 (1-2), 159-168 (2008): Mulero, M.C., et al. Biochim. Biophys. Acta 1773(3):330-341(2007). Olsen, J.V., et al. Cell 127(3):635-648(2006).

Other Notes

Small volumes of anti-RCAN3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RCAN3 purchase

MBS6341023 is an antibody targeting RCAN3. Also known as RCAN3, CT (RCAN3, DSCR1L2, Calcipressin-3, Down syndrome candidate region 1-like protein 2, Myocyte-enriched calcineurin-interacting protein 3, Regulator of calcineurin 3) (MaxLight 650). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RCAN3. It may not necessarily be applicable to this product.

NCBI GI #

7305009

NCBI GeneID

11123

NCBI Accession #

NP_038469.1

UniProt Primary Accession #

Q9UKA8

UniProt Secondary Accession #

Q5TGC6; Q9NUC8; Q9UKA7

UniProt Related Accession #

Q5ECL3; Q5TGC7; Q9UKA8

GenBank Nucleotide #

NM_013441.2

NCBI Official Full Name

calcipressin-3

NCBI Official Synonym Full Names

RCAN family member 3

NCBI Official Symbol

RCAN3

NCBI Official Synonym Symbols

RCN3; MCIP3; hRCN3; DSCR1L2

UniProt Protein Name

Calcipressin-3

UniProt Synonym Protein Names

Down syndrome candidate region 1-like protein 2; Myocyte-enriched calcineurin-interacting protein 3; MCIP3; Regulator of calcineurin 3

Protein Family

Calcipressin

UniProt Gene Name

RCAN3

UniProt Synonym Gene Names

DSCR1L2; MCIP3

UniProt Entry Name

RCAN3_HUMAN

NCBI Protein Information

calcipressin-3; OTTHUMP00000003336; Down syndrome candidate region 1-like 2; regulator of calcineurin 3 isoform 1,3,4,5; Down syndrome critical region gene 1-like 2; regulator of calcineurin 3 isoform 1a,3,4,5; regulator of calcineurin 3 isoform 1c,3,4,5;

UniProt Comments for RCAN3

RCAN3: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Belongs to the RCAN family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 1p36.11

Molecular Function: RNA binding; troponin I binding

Biological Process: anatomical structure morphogenesis; calcium-mediated signaling

Research Articles on RCAN3

1. Data shows RCAN3 inhibits HUVEC proliferation both basally and under VEGF or phorbol 12-myristate 13-acetate-stimulated conditions, however it does not modulate gene expression of the chosen inflammatory genes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RCAN3 antibody

Reference Product	PubMed Publications
TNNI3 antibody	>2 publications with RCAN3 and TNNI3

Diseases associated with anti-RCAN3 antibody

Disease Name	Pubmed Publications
Neurobehavioral Manifestations Antibodies	>2 publications with RCAN3 and Neurobehavioral Manifestations
Nervous System Diseases Antibodies	>2 publications with RCAN3 and Nervous System Diseases
Neoplasm Metastasis Antibodies	>1 publications with RCAN3 and Neoplasm Metastasis
Congenital Abnormalities Antibodies	>1 publications with RCAN3 and Congenital Abnormalities
Breast Neoplasms Antibodies	>1 publications with RCAN3 and Breast Neoplasms
Abnormalities, Multiple Antibodies	>1 publications with RCAN3 and Abnormalities, Multiple
Hypertrophy Antibodies	>1 publications with RCAN3 and Hypertrophy
Inflammation Antibodies	>1 publications with RCAN3 and Inflammation
Learning Disorders Antibodies	>1 publications with RCAN3 and Learning Disorders

Organs/Tissues associated with anti-RCAN3 antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>5 publications with RCAN3 and Muscle
Brain Antibodies	>3 publications with RCAN3 and Brain
Heart Antibodies	>2 publications with RCAN3 and Heart
Liver Antibodies	>1 publications with RCAN3 and Liver
Kidney Antibodies	>1 publications with RCAN3 and Kidney
Embryonic Tissue Antibodies	>1 publications with RCAN3 and Embryonic Tissue