RFC3 Antibody – Rabbit Polyclonal

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]

RFC3: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Belongs to the activator 1 small subunits family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 13q13.2

Cellular Component: nucleoplasm; DNA replication factor C complex; nucleus

Molecular Function: protein binding; DNA binding; ATPase activity; DNA clamp loader activity

Biological Process: telomere maintenance via semi-conservative replication; DNA synthesis during DNA repair; response to organophosphorus; nucleotide-excision repair; transcription-coupled nucleotide-excision repair; telomere maintenance via recombination; nucleotide-excision repair, DNA gap filling; mitotic cell cycle; DNA strand elongation during DNA replication; DNA repair; DNA replication; telomere maintenance