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RHOC Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6011543

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
RHOC, Polyclonal Antibody
Full Product Name
RHOC, CT (RHOC, ARH9, ARHC, Rho-related GTP-binding protein RhoC, Rho cDNA clone 9)
Product Gene Name
anti-RHOC antibody
Product Synonym Names
Anti -RHOC, CT (RHOC, ARH9, ARHC, Rho-related GTP-binding protein RhoC, Rho cDNA clone 9)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
22,006 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (113243749..113250025, complement). Location: 1p13.1
OMIM
165380
3D Structure
ModBase 3D Structure for P08134
Immunogen
RHOC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-130 amino acids from the C-terminal region of human RHOC.

Product Categories/Family for anti-RHOC antibody

Antibodies; Abs to CD Markers
Applications Tested/Suitable for anti-RHOC antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-RHOC antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-RHOC antibody

RHOC Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the RHOC antibody detected the RHOC protein (arrow).
Rabbit Anti-RHOC Polyclonal Antibody – Cat# MBS6011543

Immunohistochemistry (IHC) of anti-RHOC antibody

RHOC Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RHOC Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-RHOC Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6011543

Other Notes

Small volumes of anti-RHOC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RHOC purchase

MBS6011543 is an antibody targeting RHOC. Also known as RHOC, CT (RHOC, ARH9, ARHC, Rho-related GTP-binding protein RhoC, Rho cDNA clone 9). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RHOC. It may not necessarily be applicable to this product.

NCBI GI #
111494251
NCBI GeneID
389
NCBI Accession #
NP_001036144.1
UniProt Primary Accession #
P08134
UniProt Secondary Accession #
Q6ICN3; B3KSW1
UniProt Related Accession #
P08134
GenBank Nucleotide #
NM_001042679.1
NCBI Official Full Name
rho-related GTP-binding protein RhoC
NCBI Official Synonym Full Names
ras homolog family member C
NCBI Official Symbol
RHOC
NCBI Official Synonym Symbols
H9; ARH9; ARHC; RHOH9
UniProt Protein Name
Rho-related GTP-binding protein RhoC
UniProt Synonym Protein Names
Rho cDNA clone 9
Protein Family
GTP-binding protein
UniProt Gene Name
RHOC
UniProt Synonym Gene Names
ARH9; ARHC; h9
UniProt Entry Name
RHOC_HUMAN
NCBI Protein Information
rho-related GTP-binding protein RhoC; rhoC GTPase; oncogene RHO H9; rho cDNA clone 9; RAS-related homolog 9; small GTP binding protein RhoC; ras homolog gene family, member C

UniProt Comments for RHOC

RHOC: a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders.

Protein type: G protein; Motility/polarity/chemotaxis; G protein, monomeric; G protein, monomeric, Rho

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: plasma membrane; cytosol; nucleus; cleavage furrow

Molecular Function: signal transducer activity; protein binding; GTP binding

Biological Process: axon guidance; regulation of small GTPase mediated signal transduction; positive regulation of I-kappaB kinase/NF-kappaB cascade; apical junction assembly; small GTPase mediated signal transduction; cytokinesis
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Research Articles on RHOC

1. This study demonstrated the role of RhoC overexpression in malignant transformation of normal human hepatocytes, suggesting that RhoC may function as an oncogene in hepatocytes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RHOC antibody

 Reference Product  PubMed Publications
 ROCK1 antibody  >13 publications with RHOC and ROCK1
 DIAPH1 antibody  >6 publications with RHOC and DIAPH1
 RTKN antibody  >2 publications with RHOC and RTKN
 CAV1 antibody  >1 publications with RHOC and CAV1
 LNX1 antibody  >1 publications with RHOC and LNX1
 CSF1 antibody  >1 publications with RHOC and CSF1

Pathways associated with anti-RHOC antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 G Alpha (12/13) Signalling Events Pathway antibodies  G Alpha (12/13) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Sema4D In Semaphorin Signaling Pathway antibodies  Sema4D In Semaphorin Signaling Pathway Diagram
 Sema4D Induced Cell Migration And Growth-cone Collapse Pathway antibodies  Sema4D Induced Cell Migration And Growth-cone Collapse Pathway Diagram
 Semaphorin Interactions Pathway antibodies  Semaphorin Interactions Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-RHOC antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >214 publications with RHOC and Neoplasms
 Carcinoma Antibodies  >100 publications with RHOC and Carcinoma
 Neoplasm Metastasis Antibodies  >94 publications with RHOC and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >68 publications with RHOC and Breast Neoplasms
 Lung Neoplasms Antibodies  >29 publications with RHOC and Lung Neoplasms
 Liver Neoplasms Antibodies  >27 publications with RHOC and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >25 publications with RHOC and Neoplasms, Experimental
 Liver Diseases Antibodies  >23 publications with RHOC and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >21 publications with RHOC and Carcinoma, Hepatocellular
 Cell Transformation, Neoplastic Antibodies  >17 publications with RHOC and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-RHOC antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >25 publications with RHOC and Blood
 Prostate Antibodies  >19 publications with RHOC and Prostate
 Kidney Antibodies  >14 publications with RHOC and Kidney
 Brain Antibodies  >7 publications with RHOC and Brain
 Bone Marrow Antibodies  >5 publications with RHOC and Bone Marrow
 Mouth Antibodies  >4 publications with RHOC and Mouth
 Mammary Gland Antibodies  >3 publications with RHOC and Mammary Gland
 Intestine Antibodies  >3 publications with RHOC and Intestine
 Placenta Antibodies  >3 publications with RHOC and Placenta
 Ovary Antibodies  >2 publications with RHOC and Ovary
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