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RIP3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6497894

MBS6497894 is an antibody targeting RIP3. Also known as RIP3, NT (Receptor-interacting Serine/Threonine-protein Kinase 3, RIP-like Protein Kinase 3, Receptor-interacting Protein 3, RIP-3, RIPK3) (PE). Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RIP3, Polyclonal Antibody
Full Product Name
RIP3, NT (Receptor-interacting Serine/Threonine-protein Kinase 3, RIP-like Protein Kinase 3, Receptor-interacting Protein 3, RIP-3, RIPK3) (PE)
Product Gene Name
anti-RIP3 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein G Affinity Chromatography.
Specificity
Recognizes human RIPK3.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
25,326 Da
OMIM
605817
3D Structure
ModBase 3D Structure for Q9Y572
Immunogen
Synthetic peptide selected from the N-terminal region of human RIPK3 (KLH).
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-RIP3 antibody

Antibodies; Protein Kinases
Applications Tested/Suitable for anti-RIP3 antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-RIP3 antibody
IHC: 1:10-1:50
FLISA: 1:1,000
WB: 1:50-1:100
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-RIP3 antibody

Western blot analysis of RIP3 (RIPK3) Antibody (N-term) in Ramos cell line lysates (35ug/lane). RIPK3 (arrow) was detected using the purified Pab.
Rabbit Anti-RIP3 Polyclonal Antibody – Cat# MBS6497894

Immunohistochemistry (IHC) of anti-RIP3 antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with RIP3 (RIPK3) antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-RIP3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6497894

Product References and Citations for anti-RIP3 antibody

1. Yu P.W., Huang B.C.B., Shen M., Quast J., Chan E., Xu X., Nolan G.P., Payan D.G., Luo Y. Curr. Biol. 9:539-542(1999). 2. Sun X., Lee J., Navas T., Baldwin D.T., Stewart T.A., Dixit V.M.; J. Biol. Chem. 274:16871-16875(1999).

Other Notes

Small volumes of anti-RIP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RIP3. It may not necessarily be applicable to this product.

NCBI GI #
40254844
NCBI GeneID
11035
NCBI Accession #
NP_006862
UniProt Primary Accession #
Q9Y572
UniProt Secondary Accession #
Q5J795; Q5J796; Q6P5Y1; B4DJL9; C4AM87
UniProt Related Accession #
Q9Y572
GenBank Nucleotide #
NM_006871
NCBI Official Full Name
receptor-interacting serine/threonine-protein kinase 3
NCBI Official Synonym Full Names
receptor-interacting serine-threonine kinase 3
NCBI Official Symbol
RIPK3
NCBI Official Synonym Symbols
RIP3
UniProt Protein Name
Receptor-interacting serine/threonine-protein kinase 3
UniProt Synonym Protein Names
RIP-like protein kinase 3; Receptor-interacting protein 3; RIP-3
Protein Family
Putative zinc metalloprotease
UniProt Gene Name
RIPK3
UniProt Synonym Gene Names
RIP3; RIP-3
UniProt Entry Name
RIPK3_HUMAN
NCBI Protein Information
receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3; receptor interacting protein 3; receptor-interacting protein 3

UniProt Comments for RIP3

RIPK3: Promotes apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Kinase, protein; TKL group; RIPK family

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: mitochondrion; plasma membrane; cytosol

Molecular Function: NF-kappaB-inducing kinase activity; protein serine/threonine kinase activity; identical protein binding; protein binding; transcription coactivator activity; protein complex binding; ATP binding; protein kinase activity

Biological Process: spleen development; I-kappaB kinase/NF-kappaB cascade; regulation of activated T cell proliferation; thymus development; protein heterooligomerization; protein amino acid autophosphorylation; MyD88-independent toll-like receptor signaling pathway; T cell differentiation in the thymus; protein modification process; toll-like receptor 3 signaling pathway; signal transduction; lymph node development; activation of NF-kappaB transcription factor; regulation of T cell mediated cytotoxicity; regulation of adaptive immune response; regulation of interferon-gamma production; toll-like receptor signaling pathway; positive regulation of interferon type I production; activation of protein kinase activity; innate immune response; T cell homeostasis; positive regulation of ligase activity; toll-like receptor 4 signaling pathway; protein homooligomerization; positive regulation of oxidoreductase activity
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RIP3 antibody

 Reference Product  PubMed Publications
 RIPK1 antibody  >83 publications with RIP3 and RIPK1
 MLKL antibody  >38 publications with RIP3 and MLKL
 ZBP1 antibody  >5 publications with RIP3 and ZBP1
 TLR3 antibody  >4 publications with RIP3 and TLR3
 TICAM1 antibody  >3 publications with RIP3 and TICAM1

Pathways associated with anti-RIP3 antibody

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 IKK Complex Recruitment Mediated By RIP1 Pathway antibodies  IKK Complex Recruitment Mediated By RIP1 Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 MyD88-independent Cascade Pathway antibodies  MyD88-independent Cascade Pathway Diagram
 RIP-mediated NFkB Activation Via ZBP1 Pathway antibodies  RIP-mediated NFkB Activation Via ZBP1 Pathway Diagram
 TNF Signaling Pathway antibodies  TNF Signaling Pathway Diagram

Diseases associated with anti-RIP3 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >167 publications with RIP3 and Necrosis
 Inflammation Antibodies  >65 publications with RIP3 and Inflammation
 Cardiovascular Diseases Antibodies  >12 publications with RIP3 and Cardiovascular Diseases
 Liver Diseases Antibodies  >12 publications with RIP3 and Liver Diseases
 Drug-Induced Liver Injury Antibodies  >6 publications with RIP3 and Drug-Induced Liver Injury
 Brain Diseases Antibodies  >4 publications with RIP3 and Brain Diseases
 Drug-Related Side Effects and Adverse Reactions Antibodies  >4 publications with RIP3 and Drug-Related Side Effects and Adverse Reactions
 Liver Neoplasms Antibodies  >3 publications with RIP3 and Liver Neoplasms
 Acute Kidney Injury Antibodies  >3 publications with RIP3 and Acute Kidney Injury
 Carcinoma, Hepatocellular Antibodies  >2 publications with RIP3 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-RIP3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >27 publications with RIP3 and Blood
 Liver Antibodies  >18 publications with RIP3 and Liver
 Intestine Antibodies  >10 publications with RIP3 and Intestine
 Brain Antibodies  >9 publications with RIP3 and Brain
 Kidney Antibodies  >8 publications with RIP3 and Kidney
 Lung Antibodies  >8 publications with RIP3 and Lung
 Heart Antibodies  >6 publications with RIP3 and Heart
 Skin Antibodies  >5 publications with RIP3 and Skin
 Vascular Antibodies  >3 publications with RIP3 and Vascular
 Muscle Antibodies  >3 publications with RIP3 and Muscle
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