Rabbit Anti-RLN2 Polyclonal Antibody – Cat# MBS6342260

RLN2 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the RLN2 antibody detected the RLN2 protein (arrow).

RLN2 Antibody – Rabbit Polyclonal

Name: RLN2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6342260
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6342260

Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. The active form of the encoded… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RLN2, Polyclonal Antibody

Full Product Name

RLN2, CT (RLN2, Prorelaxin H2, Relaxin B chain, Relaxin A chain) (Biotin)

Product Gene Name

anti-RLN2 antibody

Product Synonym Names

RLN2; Prorelaxin H2; Relaxin B chain; Relaxin A chain

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

12,883 Da

OMIM

179740

3D Structure

ModBase 3D Structure for P04090

Immunogen

RLN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-165 amino acids from the C-terminal region of human RLN2.

Conjugate

Biotin

Note

Preservative Free

Product Categories/Family for anti-RLN2 antibody

Antibodies; Spermatogenesis; Testis Proteins

Applications Tested/Suitable for anti-RLN2 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-RLN2 antibody

WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-RLN2 antibody

Davila, S., et al. Genes Immun. 11(3):232-238(2010). Vogel, I., et al. In Vivo 23(6):1005-1009(2009). Dschietzig, T., et al. Regul. Pept. 155 (1-3), 163-173 (2009): Mookerjee, I., et al. FASEB J. 23(4):1219-1229(2009). Svendsen, A.M., et al. Mol. Cell. Endocrinol. 296 (1-2), 10-17 (2008).

Other Notes

Small volumes of anti-RLN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RLN2 purchase

MBS6342260 is an antibody targeting RLN2. Also known as RLN2, CT (RLN2, Prorelaxin H2, Relaxin B chain, Relaxin A chain) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RLN2. It may not necessarily be applicable to this product.

NCBI GI #

20143935

NCBI GeneID

6019

NCBI Accession #

NP_005050.2

UniProt Primary Accession #

P04090

UniProt Secondary Accession #

Q99936; Q9UCX3; Q9UQJ2; A0AVM0

UniProt Related Accession #

P04090

GenBank Nucleotide #

NM_005059.3

NCBI Official Full Name

prorelaxin H2 isoform 2

NCBI Official Synonym Full Names

relaxin 2

NCBI Official Symbol

RLN2

NCBI Official Synonym Symbols

H2; RLXH2; H2-RLX; bA12D24.1.1; bA12D24.1.2

UniProt Protein Name

Prorelaxin H2

Protein Family

Prorelaxin

UniProt Gene Name

RLN2

UniProt Entry Name

REL2_HUMAN

NCBI Protein Information

prorelaxin H2; H2-preprorelaxin; relaxin, ovarian, of pregnancy

NCBI Summary for RLN2

Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The active form of the protein encoded by this gene consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]

UniProt Comments for RLN2

RLN2: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. Belongs to the insulin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9p24.1

Cellular Component: extracellular region

Molecular Function: hormone activity

Biological Process: female pregnancy

Research Articles on RLN2

1. Benefits of relaxin-2 treatment in hypertension include reduced ADMA levels and increased NO bioavailability, possibly due to its antioxidant effects.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RLN2 antibody

Reference Product	PubMed Publications
RXFP1 antibody	>25 publications with RLN2 and RXFP1
RLN1 antibody	>23 publications with RLN2 and RLN1
RXFP2 antibody	>14 publications with RLN2 and RXFP2
INSL3 antibody	>8 publications with RLN2 and INSL3
RLN3 antibody	>8 publications with RLN2 and RLN3
RXFP3 antibody	>6 publications with RLN2 and RXFP3
RXFP4 antibody	>3 publications with RLN2 and RXFP4

Pathways associated with anti-RLN2 antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies	Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram
Relaxin Receptors Pathway antibodies	Relaxin Receptors Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram

Diseases associated with anti-RLN2 antibody

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>12 publications with RLN2 and Cardiovascular Diseases
Fibrosis Antibodies	>10 publications with RLN2 and Fibrosis
Genital Diseases, Male Antibodies	>9 publications with RLN2 and Genital Diseases, Male
Prostatic Neoplasms Antibodies	>7 publications with RLN2 and Prostatic Neoplasms
Inflammation Antibodies	>5 publications with RLN2 and Inflammation
Disease Models, Animal Antibodies	>5 publications with RLN2 and Disease Models, Animal
Breast Neoplasms Antibodies	>4 publications with RLN2 and Breast Neoplasms
Neoplasm Invasiveness Antibodies	>3 publications with RLN2 and Neoplasm Invasiveness
Neoplasm Metastasis Antibodies	>3 publications with RLN2 and Neoplasm Metastasis
Lung Diseases Antibodies	>2 publications with RLN2 and Lung Diseases

Organs/Tissues associated with anti-RLN2 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>3 publications with RLN2 and Lung
Connective Tissue Antibodies	>2 publications with RLN2 and Connective Tissue