RNF111 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

RNF111: Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin- protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.-; Ligase

Chromosomal Location of Human Ortholog: 15q21

Cellular Component: nucleoplasm; protein complex; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; zinc ion binding; SUMO polymer binding; SMAD binding; ligase activity

Biological Process: transcription initiation from RNA polymerase II promoter; protein polyubiquitination; transcription, DNA-dependent; positive regulation of protein ubiquitination; transforming growth factor beta receptor signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter; gene expression; ubiquitin-dependent SMAD protein catabolic process; pattern specification process