Rabbit Anti-RORC Polyclonal Antibody – Cat# MBS6343137

RORC Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the RORC antibody detected the RORC protein (arrow).

RORC Antibody – Rabbit Polyclonal

Name: RORC Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6343137
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6343137

The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RORC, Polyclonal Antibody

Full Product Name

RORC, ID (RORC, NR1F3, RORG, RZRG, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, Retinoid-related orphan receptor-gamma) (PE)

Product Gene Name

anti-RORC antibody

Product Synonym Names

RORC; NR1F3; RORG; RZRG; Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; Retinoid-related orphan receptor-gamma

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

58,195 Da

Chromosome Location

Chromosome: 1; NC_000001.10 (151778547..151804348, complement). Location: 1q21

OMIM

602943

3D Structure

ModBase 3D Structure for P51449

Immunogen

RORC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-216 amino acids from the Central region of human RORC.

Conjugate

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-RORC antibody

Antibodies; Receptors

Applications Tested/Suitable for anti-RORC antibody

Western Blot (WB), FLISA

Application Notes for anti-RORC antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-RORC antibody

Wang, Y., et al. Biochim. Biophys. Acta 1801(8):917-923(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Burgler, S., et al. J. Immunol. 184(11):6161-6169(2010). Jin, L., et al. Mol. Endocrinol. 24(5):923-929(2010). Wang, W.J., et al. J. Reprod. Immunol. 84(2):164-170(2010).

Other Notes

Small volumes of anti-RORC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RORC purchase

MBS6343137 is an antibody targeting RORC. Also known as RORC, ID (RORC, NR1F3, RORG, RZRG, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, Retinoid-related orphan receptor-gamma) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RORC. It may not necessarily be applicable to this product.

NCBI GI #

48255918

NCBI GeneID

6097

NCBI Accession #

NP_001001523.1

NCBI Related Accession #

NP_005051.2

UniProt Primary Accession #

P51449

UniProt Secondary Accession #

Q5SZR9; Q8N5V7; Q8NCY8

UniProt Related Accession #

P51449

GenBank Nucleotide #

NM_001001523.1

NCBI Official Full Name

nuclear receptor ROR-gamma isoform b

NCBI Official Synonym Full Names

RAR-related orphan receptor C

NCBI Official Symbol

RORC

NCBI Official Synonym Symbols

TOR; RORG; RZRG; NR1F3; RZR-GAMMA

UniProt Protein Name

Nuclear receptor ROR-gamma

UniProt Synonym Protein Names

Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; Retinoid-related orphan receptor-gamma

Protein Family

Nuclear receptor

UniProt Gene Name

RORC

UniProt Synonym Gene Names

NR1F3; RORG; RZRG

UniProt Entry Name

RORG_HUMAN

NCBI Protein Information

nuclear receptor ROR-gamma; nuclear receptor RZR-gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; RAR-related orphan receptor C, isoform a; RAR-related orphan nuclear receptor variant 2; nuclear receptor subfamily 1 gro

UniProt Comments for RORC

RORC: Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor; Transcription factor

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; ligand-dependent nuclear receptor activity; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; oxysterol binding; transcription factor activity

Biological Process: Peyer's patch development; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; T-helper cell differentiation; regulation of fat cell differentiation; positive regulation of transcription, DNA-dependent; T cell differentiation in the thymus; positive regulation of circadian rhythm; lymph node development; protein amino acid phosphorylation; regulation of gamma-delta T cell differentiation; xenobiotic metabolic process; regulation of steroid metabolic process; steroid hormone mediated signaling; gene expression; circadian regulation of gene expression

Research Articles on RORC

1. SULT2A1 as a novel ROR-alpha and ROR-gamma target gene.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RORC antibody

Reference Product	PubMed Publications
CHD4 antibody	>1 publications with RORC and CHD4

Pathways associated with anti-RORC antibody

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Diseases associated with anti-RORC antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>84 publications with RORC and Inflammation
Disease Models, Animal Antibodies	>32 publications with RORC and Disease Models, Animal
Nervous System Diseases Antibodies	>30 publications with RORC and Nervous System Diseases
Brain Diseases Antibodies	>21 publications with RORC and Brain Diseases
Necrosis Antibodies	>20 publications with RORC and Necrosis
Neoplasms Antibodies	>16 publications with RORC and Neoplasms
Liver Diseases Antibodies	>6 publications with RORC and Liver Diseases
Atherosclerosis Antibodies	>5 publications with RORC and Atherosclerosis
Drug Toxicity Antibodies	>4 publications with RORC and Drug Toxicity
Kidney Diseases Antibodies	>3 publications with RORC and Kidney Diseases

Organs/Tissues associated with anti-RORC antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>5 publications with RORC and Kidney