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RPL3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6343468

Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein… More details

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Product Overview

Online Datasheet in PDF
Product Name
RPL3, Polyclonal Antibody
Full Product Name
RPL3, ID (RPL3, 60S ribosomal protein L3, HIV-1 TAR RNA-binding protein B) (AP)
Product Gene Name
anti-RPL3 antibody
Product Synonym Names
RPL3; 60S ribosomal protein L3; HIV-1 TAR RNA-binding protein B
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
46,109 Da
Chromosome Location
Chromosome: 22; NC_000022.10 (39708887..39715670, complement). Location: 22q13
OMIM
604163
3D Structure
ModBase 3D Structure for P39023
Immunogen
RPL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-251 amino acids from the Central region of human RPL3.
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-RPL3 antibody

Antibodies; Infectious Disease HIV
Applications Tested/Suitable for anti-RPL3 antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-RPL3 antibody
IHC: 1:10-50
ELISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-RPL3 antibody

RPL3 Antibody (Center) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the RPL3 antibody detected the RPL3 protein (arrow).
Rabbit Anti-RPL3 Polyclonal Antibody – Cat# MBS6343468

Immunohistochemistry (IHC) of anti-RPL3 antibody

RPL3 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RPL3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-RPL3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6343468

Product References and Citations for anti-RPL3 antibody

Russo, A., et al. Biochim. Biophys. Acta 1799 (5-6), 419-428 (2010): Rikova, K., et al. Cell 131(6):1190-1203(2007). Tu, L.C., et al. Mol. Cell Proteomics 6(4):575-588(2007). Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007): Bergqvist, M., et al. Dis. Esophagus 19(1):20-23(2006).

Other Notes

Small volumes of anti-RPL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RPL3 purchase

MBS6343468 is an antibody targeting RPL3. Also known as RPL3, ID (RPL3, 60S ribosomal protein L3, HIV-1 TAR RNA-binding protein B) (AP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RPL3. It may not necessarily be applicable to this product.

NCBI GI #
4506649
NCBI GeneID
6122
NCBI Accession #
NP_000958.1
UniProt Primary Accession #
P39023
UniProt Secondary Accession #
Q15548; Q5I0G0; B2RDV9
UniProt Related Accession #
P39023
GenBank Nucleotide #
NM_000967.3
NCBI Official Full Name
60S ribosomal protein L3 isoform a
NCBI Official Synonym Full Names
ribosomal protein L3
NCBI Official Symbol
RPL3
NCBI Official Synonym Symbols
L3; ASC-1; TARBP-B
UniProt Protein Name
60S ribosomal protein L3
UniProt Synonym Protein Names
HIV-1 TAR RNA-binding protein B
Protein Family
50S ribosomal protein
UniProt Gene Name
RPL3
UniProt Synonym Gene Names
TARBP-B
UniProt Entry Name
RL3_HUMAN
NCBI Protein Information
60S ribosomal protein L3; hypothetical protein; HIV-1 TAR RNA-binding protein B; ribosomal protein L3, isoform a

NCBI Summary for RPL3

Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
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UniProt Comments for RPL3

RPL3: The L3 protein is a component of the large subunit of cytoplasmic ribosomes. Belongs to the ribosomal protein L3P family.

Protein type: Translation; Nucleolus; Ribosomal

Chromosomal Location of Human Ortholog: 22q13

Cellular Component: nucleoplasm; focal adhesion; cytoplasm; nucleolus; cytosol; nucleus

Molecular Function: structural constituent of ribosome; RNA binding

Biological Process: SRP-dependent cotranslational protein targeting to membrane; cellular protein metabolic process; translational elongation; viral reproduction; translation; translational initiation; mRNA catabolic process, nonsense-mediated decay; gene expression; viral transcription; translational termination; viral infectious cycle
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Research Articles on RPL3

1. NPM and KHSRP are two newly identified proteins involved in the regulation of rpL3 gene expression via alternative pre-mRNA splicing.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-RPL3 antibody

 Products by Pathway  Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 Cytoplasmic Ribosomal Proteins Pathway antibodies  Cytoplasmic Ribosomal Proteins Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Eukaryotic Translation Elongation Pathway antibodies  Eukaryotic Translation Elongation Pathway Diagram
 Eukaryotic Translation Initiation Pathway antibodies  Eukaryotic Translation Initiation Pathway Diagram
 Eukaryotic Translation Termination Pathway antibodies  Eukaryotic Translation Termination Pathway Diagram
 Formation Of A Pool Of Free 40S Subunits Pathway antibodies  Formation Of A Pool Of Free 40S Subunits Pathway Diagram
 GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway antibodies  GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Influenza Infection Pathway antibodies  Influenza Infection Pathway Diagram

Diseases associated with anti-RPL3 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >3 publications with RPL3 and Disease Models, Animal
 Drug Toxicity Antibodies  >2 publications with RPL3 and Drug Toxicity
 Anemia Antibodies  >1 publications with RPL3 and Anemia
 Kidney Diseases Antibodies  >1 publications with RPL3 and Kidney Diseases
 Fibrosis Antibodies  >1 publications with RPL3 and Fibrosis
 Neoplasms Antibodies  >1 publications with RPL3 and Neoplasms
 Inflammation Antibodies  >1 publications with RPL3 and Inflammation

Organs/Tissues associated with anti-RPL3 antibody

 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >2 publications with RPL3 and Adipose Tissue
 Brain Antibodies  >2 publications with RPL3 and Brain
 Connective Tissue Antibodies  >1 publications with RPL3 and Connective Tissue
 Bone Antibodies  >1 publications with RPL3 and Bone
 Bone Marrow Antibodies  >1 publications with RPL3 and Bone Marrow
 Blood Antibodies  >1 publications with RPL3 and Blood
 Kidney Antibodies  >1 publications with RPL3 and Kidney
 Ovary Antibodies  >1 publications with RPL3 and Ovary
 Muscle Antibodies  >1 publications with RPL3 and Muscle
 Liver Antibodies  >1 publications with RPL3 and Liver
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