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RYR2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7045803

Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes,… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
RYR2, Polyclonal Antibody
Full Product Name
RYR2 Antibody, HRP conjugated
Product Gene Name
anti-RYR2 antibody
Product Synonym Names
Ryanodine receptor 2RYR-2RyR2hRYR-2; Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Type 2 ryanodine recept; RYR2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
>95%, Protein G purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: RYR2 (MBS7045130)
HRP Conjugated Antibody: RYR2 (MBS7045803)
Molecular Weight
565,411 Da
OMIM
180902
3D Structure
ModBase 3D Structure for Q92736
Species
Human
Immunogen
Recombinant human Ryanodine receptor 2 protein
Conjugate
HRP
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-RYR2 antibody
ELISA (EIA)

Other Notes

Small volumes of anti-RYR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RYR2 purchase

MBS7045803 is an antibody targeting RYR2. Also known as RYR2 Antibody, HRP conjugated. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RYR2. It may not necessarily be applicable to this product.

NCBI GI #
112799847
NCBI GeneID
6262
NCBI Accession #
NP_001026.2
UniProt Primary Accession #
Q92736
UniProt Secondary Accession #
Q15411; Q546N8; Q5T3P2
UniProt Related Accession #
Q92736
GenBank Nucleotide #
NM_001035.2
NCBI Official Full Name
ryanodine receptor 2
NCBI Official Synonym Full Names
ryanodine receptor 2
NCBI Official Symbol
RYR2
NCBI Official Synonym Symbols
RyR; ARVC2; ARVD2; RYR-2; VTSIP
UniProt Protein Name
Ryanodine receptor 2
UniProt Synonym Protein Names
Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Type 2 ryanodine receptor
Protein Family
Ryanodine receptor
UniProt Gene Name
RYR2
UniProt Synonym Gene Names
RYR-2; RyR2; hRYR-2
UniProt Entry Name
RYR2_HUMAN
NCBI Protein Information
ryanodine receptor 2

NCBI Summary for RYR2

This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008]
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UniProt Comments for RYR2

RYR2: ryanodine receptor calcium release channel. Regulates communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Phosphorylation by PKA dissociates FKBP12.6 from RYR2. Two splice isoforms have been described.

Protein type: Membrane protein, multi-pass; Transporter, ion channel; Channel, ligand-gated; Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: membrane; plasma membrane; protein complex; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; Z disc

Molecular Function: calcium channel activity; calcium-induced calcium release activity; calcium-release channel activity; calmodulin binding; enzyme binding; identical protein binding; protein binding; ryanodine-sensitive calcium-release channel activity

Biological Process: calcium ion transport; calcium-mediated signaling; cardiac muscle contraction; cellular calcium ion homeostasis; cytosolic calcium ion homeostasis; detection of calcium ion; positive regulation of heart rate; positive regulation of sequestering of calcium ion; regulation of heart rate; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; release of sequestered calcium ion into cytosol; response to caffeine; response to hypoxia; response to muscle activity; response to redox state

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 2; Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy
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Research Articles on RYR2

1. Studies indicate that the ryanodine receptors (RyRs: RyR1, RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1, IP3R2, IP3R3) are the major Ca(2+) release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RYR2 antibody

 Reference Product  PubMed Publications
 CASQ2 antibody  >99 publications with RYR2 and CASQ2
 TRDN antibody  >47 publications with RYR2 and TRDN
 CACNA1C antibody  >26 publications with RYR2 and CACNA1C
 ASPH antibody  >25 publications with RYR2 and ASPH
 NOS1 antibody  >15 publications with RYR2 and NOS1
 CACNA1D antibody  >9 publications with RYR2 and CACNA1D
 AKAP6 antibody  >6 publications with RYR2 and AKAP6
 FKBP1B antibody  >6 publications with RYR2 and FKBP1B
 CAMK2D antibody  >4 publications with RYR2 and CAMK2D
 CAMK2G antibody  >2 publications with RYR2 and CAMK2G

Pathways associated with anti-RYR2 antibody

 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cardiac Conduction Pathway antibodies  Cardiac Conduction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram

Diseases associated with anti-RYR2 antibody

 Disease Name  Pubmed Publications
 VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1, WITH OR WITHOUT ATRIAL DYSFUNCTION AND/OR DILATED CARDIOMYOPATHY Antibodies  >20047 publications with RYR2 and VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1, WITH OR WITHOUT ATRIAL DYSFUNCTION AND/OR DILATED CARDIOMYOPATHY
 Heart Diseases Antibodies  >1081 publications with RYR2 and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >663 publications with RYR2 and Arrhythmias, Cardiac
 Heart Failure Antibodies  >490 publications with RYR2 and Heart Failure
 Tachycardia Antibodies  >408 publications with RYR2 and Tachycardia
 Tachycardia, Ventricular Antibodies  >388 publications with RYR2 and Tachycardia, Ventricular
 Disease Models, Animal Antibodies  >266 publications with RYR2 and Disease Models, Animal
 Cardiomyopathies Antibodies  >181 publications with RYR2 and Cardiomyopathies
 Vascular Diseases Antibodies  >165 publications with RYR2 and Vascular Diseases
 Myocardial Ischemia Antibodies  >121 publications with RYR2 and Myocardial Ischemia

Organs/Tissues associated with anti-RYR2 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >4297 publications with RYR2 and Muscle
 Heart Antibodies  >2275 publications with RYR2 and Heart
 Brain Antibodies  >614 publications with RYR2 and Brain
 Lung Antibodies  >149 publications with RYR2 and Lung
 Embryonic Tissue Antibodies  >134 publications with RYR2 and Embryonic Tissue
 Kidney Antibodies  >101 publications with RYR2 and Kidney
 Pancreas Antibodies  >87 publications with RYR2 and Pancreas
 Eye Antibodies  >53 publications with RYR2 and Eye
 Liver Antibodies  >53 publications with RYR2 and Liver
 Intestine Antibodies  >47 publications with RYR2 and Intestine
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