SCARB1 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

SCARB1: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester. Belongs to the CD36 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: cell surface; lysosomal membrane; microvillus membrane; integral to plasma membrane; plasma membrane; caveola

Molecular Function: apolipoprotein A-I binding; protein binding; protein homodimerization activity; lipopolysaccharide binding; transporter activity; phosphatidylserine binding; low-density lipoprotein binding; lipopolysaccharide receptor activity; apolipoprotein binding; high-density lipoprotein binding; phosphatidylinositol binding

Biological Process: receptor-mediated endocytosis; wound healing; blood vessel endothelial cell migration; viral reproduction; positive regulation of nitric-oxide synthase activity; lipoprotein metabolic process; cholesterol efflux; androgen biosynthetic process; regulation of phagocytosis; recognition of apoptotic cell; lipopolysaccharide transport; cholesterol homeostasis; reverse cholesterol transport; detection of lipopolysaccharide; endothelial cell proliferation; lipopolysaccharide-mediated signaling pathway; adhesion to host; phospholipid transport; cholesterol catabolic process; cell adhesion

Disease: High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 6